ID A0A1X7FID1_9BACI Unreviewed; 198 AA.
AC A0A1X7FID1; A0A0H4KSK1;
DT 05-JUL-2017, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2017, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=HTH-type transcriptional regulator Hpr {ECO:0000256|HAMAP-Rule:MF_01911};
DE AltName: Full=Protease production regulatory protein Hpr {ECO:0000256|HAMAP-Rule:MF_01911};
GN Name=hpr {ECO:0000256|HAMAP-Rule:MF_01911};
GN ORFNames=B1B01_16625 {ECO:0000313|EMBL:OXS67120.1}, BEH_03455
GN {ECO:0000313|EMBL:AKO91248.1}, CJ485_11650
GN {ECO:0000313|EMBL:RJS65380.1}, SAMN06296056_104109
GN {ECO:0000313|EMBL:SMF52095.1};
OS Priestia filamentosa.
OC Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Priestia.
OX NCBI_TaxID=1402861 {ECO:0000313|EMBL:SMF52095.1, ECO:0000313|Proteomes:UP000192915};
RN [1] {ECO:0000313|EMBL:AKO91248.1, ECO:0000313|Proteomes:UP000036202}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hbe603 {ECO:0000313|EMBL:AKO91248.1,
RC ECO:0000313|Proteomes:UP000036202};
RX PubMed=26248285;
RA Jia N., Du J., Ding M.Z., Gao F., Yuan Y.J.;
RT "Genome Sequence of Bacillus endophyticus and Analysis of Its Companion
RT Mechanism in the Ketogulonigenium vulgare-Bacillus Strain Consortium.";
RL PLoS ONE 10:E0135104-E0135104(2015).
RN [2] {ECO:0000313|Proteomes:UP000036202}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hbe603 {ECO:0000313|Proteomes:UP000036202};
RA Jia N., Du J., Ding M.-Z., Gao F., Yuan Y.-J.;
RT "Genome Sequence of Bacillus endophyticus and Analysis of its Companion
RT Mechanism in the Ketogulonigenium vulgare-Bacillus strain Consortium.";
RL Submitted (JUN-2015) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:AKO91248.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Hbe603 {ECO:0000313|EMBL:AKO91248.1};
RA Lavstsen T., Jespersen J.S.;
RL Submitted (MAY-2016) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|Proteomes:UP000215399}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 27955 {ECO:0000313|Proteomes:UP000215399};
RA Dastager S.G., Neurgaonkar P.S., Dharne M.S.;
RT "Bacillus sp. V-88(T) DSM27956, whole genome shotgun sequencing project.";
RL Submitted (MAR-2017) to the EMBL/GenBank/DDBJ databases.
RN [5] {ECO:0000313|Proteomes:UP000192915}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SGD-14 {ECO:0000313|Proteomes:UP000192915};
RA Varghese N., Submissions S.;
RL Submitted (APR-2017) to the EMBL/GenBank/DDBJ databases.
RN [6] {ECO:0000313|EMBL:SMF52095.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 27955 {ECO:0000313|EMBL:OXS67120.1}, and SGD-14
RC {ECO:0000313|EMBL:SMF52095.1};
RA Afonso C.L., Miller P.J., Scott M.A., Spackman E., Goraichik I.,
RA Dimitrov K.M., Suarez D.L., Swayne D.E.;
RL Submitted (APR-2017) to the EMBL/GenBank/DDBJ databases.
RN [7] {ECO:0000313|EMBL:RJS65380.1, ECO:0000313|Proteomes:UP000274910}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PK5_39 {ECO:0000313|EMBL:RJS65380.1,
RC ECO:0000313|Proteomes:UP000274910};
RA Bokhari A., Bougouffa S., Essack M., Andres-Barrao C., Saad M., Bajic V.B.,
RA Hirt H.;
RT "Complete genomes of four Endophytic plant-growth promoting Bacillus that
RT were isolated from a desert in Pakistan.";
RL Submitted (AUG-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Negative regulator of protease production and sporulation.
CC {ECO:0000256|HAMAP-Rule:MF_01911}.
CC -!- SUBUNIT: Homodimer. {ECO:0000256|HAMAP-Rule:MF_01911}.
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DR EMBL; CP011974; AKO91248.1; -; Genomic_DNA.
DR EMBL; MWSI01000004; OXS67120.1; -; Genomic_DNA.
DR EMBL; NQYF01000001; RJS65380.1; -; Genomic_DNA.
DR EMBL; FXAJ01000004; SMF52095.1; -; Genomic_DNA.
DR RefSeq; WP_040057190.1; NZ_NQYF01000001.1.
DR AlphaFoldDB; A0A1X7FID1; -.
DR KEGG; beo:BEH_03455; -.
DR PATRIC; fig|135735.6.peg.643; -.
DR OrthoDB; 2393954at2; -.
DR Proteomes; UP000036202; Chromosome.
DR Proteomes; UP000192915; Unassembled WGS sequence.
DR Proteomes; UP000215399; Unassembled WGS sequence.
DR Proteomes; UP000274910; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0045892; P:negative regulation of DNA-templated transcription; IEA:UniProtKB-UniRule.
DR GO; GO:0030435; P:sporulation resulting in formation of a cellular spore; IEA:UniProtKB-UniRule.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR HAMAP; MF_01911; HTH_type_Hpr; 1.
DR InterPro; IPR000835; HTH_MarR-typ.
DR InterPro; IPR023488; HTH_tscrpt_reg_Hpr.
DR InterPro; IPR039422; MarR/SlyA-like.
DR InterPro; IPR023187; Tscrpt_reg_MarR-type_CS.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR33164:SF58; DNA-BINDING TRANSCRIPTIONAL REPRESSOR SCOC; 1.
DR PANTHER; PTHR33164; TRANSCRIPTIONAL REGULATOR, MARR FAMILY; 1.
DR Pfam; PF01047; MarR; 1.
DR SMART; SM00347; HTH_MARR; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS01117; HTH_MARR_1; 1.
DR PROSITE; PS50995; HTH_MARR_2; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|HAMAP-Rule:MF_01911};
KW Reference proteome {ECO:0000313|Proteomes:UP000036202};
KW Repressor {ECO:0000256|HAMAP-Rule:MF_01911};
KW Sporulation {ECO:0000256|ARBA:ARBA00022969, ECO:0000256|HAMAP-
KW Rule:MF_01911}; Transcription {ECO:0000256|HAMAP-Rule:MF_01911};
KW Transcription regulation {ECO:0000256|HAMAP-Rule:MF_01911}.
FT DOMAIN 14..158
FT /note="HTH marR-type"
FT /evidence="ECO:0000259|PROSITE:PS50995"
SQ SEQUENCE 198 AA; 23337 MW; 462B641F684BFBED CRC64;
MKLQNEKEFT MKEALVFSQR MAQLSKALWK AVEKDWQQWI KPYDLNINEH HILWIAYNLK
GASISEIAKF GVMHVSTAFN FSKKLEERGL LQFSKRENDK RNTYIELTDE GNGILTNLME
NYNPTESTLF QGALPLQECY GKFPEFIELM TIVRKVYGDD FMEIFEHSFH NIDEEMDEKD
GKLRKKENIV EIEKAVVQ
//
