ID A0A1X7FN20_9ACTN Unreviewed; 709 AA.
AC A0A1X7FN20;
DT 05-JUL-2017, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2017, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE RecName: Full=aminodeoxychorismate synthase {ECO:0000256|ARBA:ARBA00013139};
DE EC=2.6.1.85 {ECO:0000256|ARBA:ARBA00013139};
GN ORFNames=SAMN02745830_04330 {ECO:0000313|EMBL:SMF54535.1};
OS Streptomyces sp. Amel2xC10.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1305826 {ECO:0000313|EMBL:SMF54535.1, ECO:0000313|Proteomes:UP000192930};
RN [1] {ECO:0000313|EMBL:SMF54535.1, ECO:0000313|Proteomes:UP000192930}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Amel2xC10 {ECO:0000313|EMBL:SMF54535.1,
RC ECO:0000313|Proteomes:UP000192930};
RA Afonso C.L., Miller P.J., Scott M.A., Spackman E., Goraichik I.,
RA Dimitrov K.M., Suarez D.L., Swayne D.E.;
RL Submitted (APR-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: In the C-terminal section; belongs to the anthranilate
CC synthase component I family. {ECO:0000256|ARBA:ARBA00005970}.
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DR EMBL; FWZW01000009; SMF54535.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1X7FN20; -.
DR OrthoDB; 3518032at2; -.
DR Proteomes; UP000192930; Unassembled WGS sequence.
DR GO; GO:0046820; F:4-amino-4-deoxychorismate synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0009396; P:folic acid-containing compound biosynthetic process; IEA:InterPro.
DR GO; GO:0006541; P:glutamine metabolic process; IEA:UniProtKB-UniRule.
DR CDD; cd01743; GATase1_Anthranilate_Synthase; 1.
DR Gene3D; 3.40.50.880; -; 1.
DR Gene3D; 3.60.120.10; Anthranilate synthase; 1.
DR InterPro; IPR005802; ADC_synth_comp_1.
DR InterPro; IPR005801; ADC_synthase.
DR InterPro; IPR019999; Anth_synth_I-like.
DR InterPro; IPR006805; Anth_synth_I_N.
DR InterPro; IPR015890; Chorismate_C.
DR InterPro; IPR029062; Class_I_gatase-like.
DR InterPro; IPR017926; GATASE.
DR InterPro; IPR006221; TrpG/PapA_dom.
DR NCBIfam; TIGR00553; pabB; 1.
DR NCBIfam; TIGR00566; trpG_papA; 1.
DR PANTHER; PTHR11236; AMINOBENZOATE/ANTHRANILATE SYNTHASE; 1.
DR PANTHER; PTHR11236:SF18; AMINODEOXYCHORISMATE SYNTHASE; 1.
DR Pfam; PF04715; Anth_synt_I_N; 1.
DR Pfam; PF00425; Chorismate_bind; 1.
DR Pfam; PF00117; GATase; 1.
DR PRINTS; PR00097; ANTSNTHASEII.
DR PRINTS; PR00099; CPSGATASE.
DR PRINTS; PR00096; GATASE.
DR SUPFAM; SSF56322; ADC synthase; 1.
DR SUPFAM; SSF52317; Class I glutamine amidotransferase-like; 1.
DR PROSITE; PS51273; GATASE_TYPE_1; 1.
PE 3: Inferred from homology;
KW Glutamine amidotransferase {ECO:0000256|PROSITE-ProRule:PRU00605};
KW Reference proteome {ECO:0000313|Proteomes:UP000192930};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 4..184
FT /note="Glutamine amidotransferase"
FT /evidence="ECO:0000259|Pfam:PF00117"
FT DOMAIN 218..357
FT /note="Anthranilate synthase component I N-terminal"
FT /evidence="ECO:0000259|Pfam:PF04715"
FT DOMAIN 417..671
FT /note="Chorismate-utilising enzyme C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00425"
FT ACT_SITE 81
FT /note="Nucleophile"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00605"
FT ACT_SITE 168
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00605"
FT ACT_SITE 170
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00605"
SQ SEQUENCE 709 AA; 76791 MW; 30E524AB785DE1A3 CRC64;
MRTLLIDNYD SFTYNLYQLL GETNGRPPVV VKNGTDFADL RFEDFDAIVI SPGPGRPDRE
RDFGISRRAI LESGLPVLGV CLGHQGICHL FGGEVVHAPE PMHGRVCPVR HSGTDIFAGL
PSPYDVVRYH SLAAGRLPDE LEALAWTEDG VVMGVRHRTR PIWGVQFHPE SISSQYGREL
LANFRDLALA HHAARRREPR YTVHVRRVDA EPRAEAAYRE LFADHDTAFW LDSSSVIDGL
SRFSFLGDGS GPLAEYVTYR VEDGVVRITR PGGSDDGDEL VQQGFFDYLD EQMRVRAVPR
PEGLPFDFNL GYVGYLGYEL KAEAGARAAH KAETPDAAVL FADRMLALDH AEGAAYLLAL
SEGGDHTAAV AWLDRAEAAV RALPRAGGEP RGEAAGFRGV GMTDPEAAPI VAPRHDKRAY
LDRIAESLEE IRDGETYEVC LTNAVELKAR IDPLRTYSHL RKISPVPYGA LLDFPGVAVL
SASPERFLTI GADRVAESKP IKGTRPRGAT PAEDAALRED LLSQEKDRAE NLMIVDLIRN
DLNVVCEVGS VHVPSLFHVE TYAPVHQLVS TIRGTLRSGE SAVSCVRAAF PGGSMTGAPK
LRTMEIIDRL EDGARGVYSG SIGWFSLSGA ADLNIVIRTL VATEDRLGFG VGGAIIALSD
PEEEYTETAV KSRAVVSAVL ATALEPAALA TAPEPAALAT APEPAGSRP
//
