ID A0A1X7GYP8_9PROT Unreviewed; 374 AA.
AC A0A1X7GYP8;
DT 05-JUL-2017, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2017, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=Citrate synthase {ECO:0000256|PIRNR:PIRNR001369};
GN ORFNames=SAMN02744631_0713 {ECO:0000313|EMBL:SMF76564.1};
OS Candidatus Pelagibacter sp. HIMB1321.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Candidatus Pelagibacterales;
OC Candidatus Pelagibacteraceae; Pelagibacter.
OX NCBI_TaxID=1388755 {ECO:0000313|EMBL:SMF76564.1, ECO:0000313|Proteomes:UP000192921};
RN [1] {ECO:0000313|Proteomes:UP000192921}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HIMB1321 {ECO:0000313|Proteomes:UP000192921};
RA Varghese N., Submissions S.;
RL Submitted (APR-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=acetyl-CoA + H2O + oxaloacetate = citrate + CoA + H(+);
CC Xref=Rhea:RHEA:16845, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:16452, ChEBI:CHEBI:16947, ChEBI:CHEBI:57287,
CC ChEBI:CHEBI:57288; EC=2.3.3.16;
CC Evidence={ECO:0000256|ARBA:ARBA00000308};
CC -!- PATHWAY: Carbohydrate metabolism; tricarboxylic acid cycle; isocitrate
CC from oxaloacetate: step 1/2. {ECO:0000256|ARBA:ARBA00004751}.
CC -!- SIMILARITY: Belongs to the citrate synthase family.
CC {ECO:0000256|ARBA:ARBA00010566, ECO:0000256|PIRNR:PIRNR001369,
CC ECO:0000256|RuleBase:RU003406}.
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DR EMBL; LT840186; SMF76564.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1X7GYP8; -.
DR STRING; 1388755.SAMN02744631_0713; -.
DR OrthoDB; 9800864at2; -.
DR UniPathway; UPA00223; UER00717.
DR Proteomes; UP000192921; Chromosome i.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0036440; F:citrate synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-UniPathway.
DR Gene3D; 1.10.580.10; Citrate Synthase, domain 1; 1.
DR Gene3D; 1.10.230.10; Cytochrome P450-Terp, domain 2; 1.
DR InterPro; IPR011278; 2-MeCitrate/Citrate_synth_II.
DR InterPro; IPR016142; Citrate_synth-like_lrg_a-sub.
DR InterPro; IPR016143; Citrate_synth-like_sm_a-sub.
DR InterPro; IPR002020; Citrate_synthase.
DR InterPro; IPR019810; Citrate_synthase_AS.
DR InterPro; IPR024176; Citrate_synthase_bac-typ.
DR InterPro; IPR036969; Citrate_synthase_sf.
DR NCBIfam; TIGR01800; cit_synth_II; 1.
DR PANTHER; PTHR11739; CITRATE SYNTHASE; 1.
DR PANTHER; PTHR11739:SF4; CITRATE SYNTHASE, PEROXISOMAL; 1.
DR Pfam; PF00285; Citrate_synt; 1.
DR PIRSF; PIRSF001369; Citrate_synth; 1.
DR PRINTS; PR00143; CITRTSNTHASE.
DR SUPFAM; SSF48256; Citrate synthase; 1.
DR PROSITE; PS00480; CITRATE_SYNTHASE; 1.
PE 3: Inferred from homology;
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|PIRNR:PIRNR001369}.
FT ACT_SITE 260
FT /evidence="ECO:0000256|PIRSR:PIRSR001369-1"
FT ACT_SITE 311
FT /evidence="ECO:0000256|PIRSR:PIRSR001369-1"
SQ SEQUENCE 374 AA; 42746 MW; D8FE482955B8A1C9 CRC64;
MADDVKKGLL GIVVDETEVS KVMPEINSLT YRGYAAQDLC EYCKFEEVAY LILNKDLPNS
IQLKKFEKEE RNNRELSKDL YAIVKRMPKK SHPMDVARTA VSFMGLEDKE TSNSSPEANM
RKALRIFAKT PTALAAFYRL RKGKKIIKPK KNLSFAENFF YMCFGKVPQK EIVKAFDVSL
ILYAEHSFNV STFTARTITS SLSDIHGAIS GAIASLKGPL HGGANEEVMH MMDKIKKPEN
ALKWINNALE NKEVVMGFGH RVYKSGDSRV PTMREYFGKV AKIKKDKKFE KIYDIVEKVM
IEKKNIYPNV DYPTGPTYHL MGFDTDFFTP IFVISRITGW SAHIMEQHAA NKLIRPLAKY
KGSQHRKVLE LNYR
//
