ID   A0A1X7H4D4_9PROT        Unreviewed;       743 AA.
AC   A0A1X7H4D4;
DT   05-JUL-2017, integrated into UniProtKB/TrEMBL.
DT   05-JUL-2017, sequence version 1.
DT   27-MAR-2024, entry version 20.
DE   SubName: Full=NDP-sugar epimerase, includes UDP-GlcNAc-inverting 4,6-dehydratase FlaA1 and capsular polysaccharide biosynthesis protein EpsC {ECO:0000313|EMBL:SMF79386.1};
GN   ORFNames=SAMN02744631_1030 {ECO:0000313|EMBL:SMF79386.1};
OS   Candidatus Pelagibacter sp. HIMB1321.
OC   Bacteria; Pseudomonadota; Alphaproteobacteria; Candidatus Pelagibacterales;
OC   Candidatus Pelagibacteraceae; Pelagibacter.
OX   NCBI_TaxID=1388755 {ECO:0000313|EMBL:SMF79386.1, ECO:0000313|Proteomes:UP000192921};
RN   [1] {ECO:0000313|Proteomes:UP000192921}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=HIMB1321 {ECO:0000313|Proteomes:UP000192921};
RA   Varghese N., Submissions S.;
RL   Submitted (APR-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the polysaccharide synthase family.
CC       {ECO:0000256|ARBA:ARBA00007430}.
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DR   EMBL; LT840186; SMF79386.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1X7H4D4; -.
DR   STRING; 1388755.SAMN02744631_1030; -.
DR   OrthoDB; 9803111at2; -.
DR   Proteomes; UP000192921; Chromosome i.
DR   CDD; cd08946; SDR_e; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 3.
DR   InterPro; IPR001509; Epimerase_deHydtase.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR003869; Polysac_CapD-like.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   PANTHER; PTHR43318:SF1; POLYSACCHARIDE BIOSYNTHESIS PROTEIN EPSC-RELATED; 1.
DR   PANTHER; PTHR43318; UDP-N-ACETYLGLUCOSAMINE 4,6-DEHYDRATASE; 1.
DR   Pfam; PF01370; Epimerase; 1.
DR   Pfam; PF02719; Polysacc_synt_2; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 2.
DR   SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
PE   3: Inferred from homology;
FT   DOMAIN          78..212
FT                   /note="NAD-dependent epimerase/dehydratase"
FT                   /evidence="ECO:0000259|Pfam:PF01370"
FT   DOMAIN          427..704
FT                   /note="Polysaccharide biosynthesis protein CapD-like"
FT                   /evidence="ECO:0000259|Pfam:PF02719"
SQ   SEQUENCE   743 AA;  86482 MW;  E2FD0EDF303D1636 CRC64;
     MIKTIIFGKR SSLTNSIIKK IKKFEVISSS NINFDNLKFD DSQKKNYIFN NFYPSFKLNT
     LSPTQYESFL NLSLVNLIKI LSNLSIKNIN KIIYTSSSSV YGIDEDLKHS SSDKYNRKIY
     SSFKYSSEKI IQNFCQNRKI NFYIMRLFNT YGDTTDQFSF IEKLIHSKKN NLKLTLINNG
     VSLRDFINID DVALIYKKFL EKKCDDGIYD IGTGQGKLIQ NLVDFVNFDK KKLIKKNNSH
     EISNSIADIT RLTKNIGNIK FKSLENYLMR NLRISKKKVF FSTKFNYSNV EYKGSVIYGA
     GFAGEKLFLR LKKKEKIIFF VDDDPKKQNN LFNNIPIISF DSLKQINRRK IIDKIYIAMP
     SLSNLEIDNL NIKLRKYFFD VRYLPEKKFL NNNYINLNDL KNDQLNLFLN RKPIYIDKIK
     GLKKKNILVT GAVGTIGFEI CRQLIYQNAK NVVGIDKSEI GIYEKKDQID KRFKLKLCDI
     NDSTLINQII SKNKIDLIIH AAAYKHVNIL EKNVHAAVVN NIIGTKTLCE VAVKKNIDLI
     LISTDKAAQP KSVLGYSKKI CEQIIHFYNK NSKKNYMNIV RFGNVFGSSG SAITKFIEQI
     NNNEPLTITN KSATRFFMTI LEACYLVIKT TSFKIRNKTF ILNMGNPINI YELAQKLGEY
     KKNLDPEYEI KFIETGLKKN EKLHEKLHEK KEKLRKVNHN VFYVSNNNFS YHKFNKLFLN
     LEKNYKYYSS GKIINCLQEI CKI
//