ID A0A1X7IEY5_9MICO Unreviewed; 391 AA.
AC A0A1X7IEY5;
DT 05-JUL-2017, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2017, sequence version 1.
DT 24-JAN-2024, entry version 24.
DE SubName: Full=Adenosylhomocysteinase {ECO:0000313|EMBL:SMG12906.1};
GN ORFNames=SAMN06296010_0424 {ECO:0000313|EMBL:SMG12906.1};
OS Agreia pratensis.
OC Bacteria; Actinomycetota; Actinomycetes; Micrococcales; Microbacteriaceae;
OC Agreia.
OX NCBI_TaxID=150121 {ECO:0000313|EMBL:SMG12906.1, ECO:0000313|Proteomes:UP000193244};
RN [1] {ECO:0000313|EMBL:SMG12906.1, ECO:0000313|Proteomes:UP000193244}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=VKM Ac-2510 {ECO:0000313|EMBL:SMG12906.1,
RC ECO:0000313|Proteomes:UP000193244};
RA Afonso C.L., Miller P.J., Scott M.A., Spackman E., Goraichik I.,
RA Dimitrov K.M., Suarez D.L., Swayne D.E.;
RL Submitted (APR-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=NAD(+); Xref=ChEBI:CHEBI:57540;
CC Evidence={ECO:0000256|ARBA:ARBA00001911};
CC -!- SIMILARITY: Belongs to the adenosylhomocysteinase family.
CC {ECO:0000256|ARBA:ARBA00007122}.
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DR EMBL; FXAY01000001; SMG12906.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1X7IEY5; -.
DR STRING; 150121.SAMN06296010_0424; -.
DR OrthoDB; 9802717at2; -.
DR Proteomes; UP000193244; Unassembled WGS sequence.
DR GO; GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.1480; Adenosylhomocysteinase-like; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR042172; Adenosylhomocyst_ase-like_sf.
DR InterPro; IPR000043; Adenosylhomocysteinase-like.
DR InterPro; IPR015878; Ado_hCys_hydrolase_NAD-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR020082; S-Ado-L-homoCys_hydrolase_CS.
DR PANTHER; PTHR23420; ADENOSYLHOMOCYSTEINASE; 1.
DR PANTHER; PTHR23420:SF0; ADENOSYLHOMOCYSTEINASE; 1.
DR Pfam; PF05221; AdoHcyase; 1.
DR Pfam; PF00670; AdoHcyase_NAD; 1.
DR SMART; SM00996; AdoHcyase; 1.
DR SMART; SM00997; AdoHcyase_NAD; 1.
DR SUPFAM; SSF52283; Formate/glycerate dehydrogenase catalytic domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS00739; ADOHCYASE_2; 1.
PE 3: Inferred from homology;
KW NAD {ECO:0000256|ARBA:ARBA00023027};
KW One-carbon metabolism {ECO:0000256|ARBA:ARBA00022563}.
FT DOMAIN 174..335
FT /note="S-adenosyl-L-homocysteine hydrolase NAD binding"
FT /evidence="ECO:0000259|SMART:SM00997"
SQ SEQUENCE 391 AA; 41406 MW; 0693157D0440EDFC CRC64;
MTALIDSAAA RVEWIRSRMR LLAAVREKFA ETRPFEGHRI GMSLHIEPKT AVLLETLAAG
GAEIVGTGNH GSTQDDVVAY LQNQGMTLFG RRDDSLDQHH ANVASVLDAT PDILLDNGAD
LAAGIVARGA GATLIGGTEE TTSGGDRLRS ELLGQVPFPV IVINDSMLKQ LGENKHAVGQ
SVVESFMRIT NLMIPGRRFV VVGYGWCGRG VAQYLRALGG KVAVAEVDEL KAFEAALDGF
RVDTADGLAG WGEVFITATG RPNVLTMSAI DRMGDGAILA NCGHFPWEID TASLRTSATA
TRAIDDTIER IELPNGRHVI LIAGGRMFNL AGTAPKGNSL DSMDLGFLLQ VLSLERVATG
AGTLVAGAQP VPDDLEREIA RRMVAAMGAS L
//
