ID A0A1X7IHX8_9BACT Unreviewed; 588 AA.
AC A0A1X7IHX8;
DT 05-JUL-2017, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2017, sequence version 1.
DT 24-JAN-2024, entry version 19.
DE SubName: Full=NAD(P)-dependent iron-only hydrogenase catalytic subunit {ECO:0000313|EMBL:SMG14173.1};
GN ORFNames=SAMN06275492_10265 {ECO:0000313|EMBL:SMG14173.1};
OS Dethiosulfovibrio salsuginis.
OC Bacteria; Synergistota; Synergistia; Synergistales;
OC Dethiosulfovibrionaceae; Dethiosulfovibrio.
OX NCBI_TaxID=561720 {ECO:0000313|EMBL:SMG14173.1, ECO:0000313|Proteomes:UP000193355};
RN [1] {ECO:0000313|EMBL:SMG14173.1, ECO:0000313|Proteomes:UP000193355}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=USBA 82 {ECO:0000313|EMBL:SMG14173.1,
RC ECO:0000313|Proteomes:UP000193355};
RA Afonso C.L., Miller P.J., Scott M.A., Spackman E., Goraichik I.,
RA Dimitrov K.M., Suarez D.L., Swayne D.E.;
RL Submitted (APR-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC Evidence={ECO:0000256|ARBA:ARBA00001966};
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DR EMBL; FXBB01000002; SMG14173.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1X7IHX8; -.
DR STRING; 561720.SAMN06275492_10265; -.
DR Proteomes; UP000193355; Unassembled WGS sequence.
DR GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR GO; GO:0008901; F:ferredoxin hydrogenase activity; IEA:InterPro.
DR GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR CDD; cd00207; fer2; 1.
DR Gene3D; 3.10.20.740; -; 1.
DR Gene3D; 3.30.70.20; -; 1.
DR Gene3D; 3.40.50.1780; -; 1.
DR Gene3D; 4.10.260.20; Iron hydrogenase, small subunit; 1.
DR InterPro; IPR036010; 2Fe-2S_ferredoxin-like_sf.
DR InterPro; IPR001041; 2Fe-2S_ferredoxin-type.
DR InterPro; IPR017896; 4Fe4S_Fe-S-bd.
DR InterPro; IPR017900; 4Fe4S_Fe_S_CS.
DR InterPro; IPR009016; Fe_hydrogenase.
DR InterPro; IPR004108; Fe_hydrogenase_lsu_C.
DR InterPro; IPR003149; Fe_hydrogenase_ssu.
DR InterPro; IPR036991; Fe_hydrogenase_ssu_sf.
DR InterPro; IPR013352; Fe_hydrogenase_subset.
DR InterPro; IPR019574; NADH_UbQ_OxRdtase_Gsu_4Fe4S-bd.
DR NCBIfam; TIGR02512; FeFe_hydrog_A; 1.
DR NCBIfam; NF040763; FeFe_hydrog_A6; 1.
DR PANTHER; PTHR11615:SF345; CATALYTIC SUBUNIT OF IRON-ONLY HYDROGENASE-RELATED; 1.
DR PANTHER; PTHR11615; NITRATE, FORMATE, IRON DEHYDROGENASE; 1.
DR Pfam; PF02906; Fe_hyd_lg_C; 1.
DR Pfam; PF02256; Fe_hyd_SSU; 1.
DR Pfam; PF13510; Fer2_4; 1.
DR Pfam; PF12838; Fer4_7; 1.
DR Pfam; PF10588; NADH-G_4Fe-4S_3; 1.
DR SMART; SM00902; Fe_hyd_SSU; 1.
DR SMART; SM00929; NADH-G_4Fe-4S_3; 1.
DR SUPFAM; SSF54292; 2Fe-2S ferredoxin-like; 1.
DR SUPFAM; SSF54862; 4Fe-4S ferredoxins; 1.
DR SUPFAM; SSF53920; Fe-only hydrogenase; 1.
DR PROSITE; PS51085; 2FE2S_FER_2; 1.
DR PROSITE; PS00198; 4FE4S_FER_1; 1.
DR PROSITE; PS51379; 4FE4S_FER_2; 2.
DR PROSITE; PS51839; 4FE4S_HC3; 1.
PE 4: Predicted;
KW 4Fe-4S {ECO:0000256|ARBA:ARBA00022485};
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723}.
FT DOMAIN 3..86
FT /note="2Fe-2S ferredoxin-type"
FT /evidence="ECO:0000259|PROSITE:PS51085"
FT DOMAIN 86..125
FT /note="4Fe-4S His(Cys)3-ligated-type"
FT /evidence="ECO:0000259|PROSITE:PS51839"
FT DOMAIN 145..175
FT /note="4Fe-4S ferredoxin-type"
FT /evidence="ECO:0000259|PROSITE:PS51379"
FT DOMAIN 188..217
FT /note="4Fe-4S ferredoxin-type"
FT /evidence="ECO:0000259|PROSITE:PS51379"
SQ SEQUENCE 588 AA; 64361 MW; 8D17EA1A14D0D653 CRC64;
MSKMIDLTID GRPVSVPEGS TILDAAKKLD INIPTLCHLD LEGTPMVNKA ASCRICVVEV
EGRRNLAPSC ATPATNGMVI KTNTIRVLNA RKTVMELLLS DHPKDCLVCA KSGNCELQDL
AEKFGLRENR FEHGAQSTYV KDVSPAIERD MNKCIMCRRC ETMCNEVQTV GALSGINRGF
DAVVSPAFEM PLDESVCTFC GQCVAVCPTG ALVERDYTWK VIEALADPDK VVVVQTAPAV
RAALGEEFGY EPGTLVTGKM AAALRTLGFD HVFDTDFAAD LTIMEEASEF LDRLTRHLEG
DTSVKLPILT SCCPAWVKFF EHQYPDLMDV PSTAKSPQQM FGAIAKSFYA EKLGIPRDKM
VVVSIMPCLA KKYECAREEF SVDGNPDVDL SITTRELAHM IKQANIDFRN LPDEDFDDPM
GASTGAAVIF GTTGGVIEAA VRSAAEWATG QELDKVDFES LRGLDGCREA KIPVGDLVLH
IGIAHGLGNA RRLLDAVRNN EVEPFHAIEI MACPGGCVGG GGQPYHHGHM EIVAKRAQAL
YREDEGKPIR KSHENPSIKA LYEEYLGKPL GEKAHHLLHT HYFKRHKI
//
