ID   A0A1X7J6W7_9BACL        Unreviewed;       447 AA.
AC   A0A1X7J6W7;
DT   05-JUL-2017, integrated into UniProtKB/TrEMBL.
DT   05-JUL-2017, sequence version 1.
DT   27-MAR-2024, entry version 13.
DE   RecName: Full=Probable multidrug resistance protein NorM {ECO:0000256|ARBA:ARBA00020268};
DE   AltName: Full=Multidrug-efflux transporter {ECO:0000256|ARBA:ARBA00031636};
GN   ORFNames=SAMN06295960_1275 {ECO:0000313|EMBL:SMG23148.1};
OS   Paenibacillus aquistagni.
OC   Bacteria; Bacillota; Bacilli; Bacillales; Paenibacillaceae; Paenibacillus.
OX   NCBI_TaxID=1852522 {ECO:0000313|EMBL:SMG23148.1, ECO:0000313|Proteomes:UP000193834};
RN   [1] {ECO:0000313|EMBL:SMG23148.1, ECO:0000313|Proteomes:UP000193834}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=11 {ECO:0000313|EMBL:SMG23148.1,
RC   ECO:0000313|Proteomes:UP000193834};
RA   Afonso C.L., Miller P.J., Scott M.A., Spackman E., Goraichik I.,
RA   Dimitrov K.M., Suarez D.L., Swayne D.E.;
RL   Submitted (APR-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Multidrug efflux pump. {ECO:0000256|ARBA:ARBA00003408}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the multi antimicrobial extrusion (MATE) (TC
CC       2.A.66.1) family. {ECO:0000256|ARBA:ARBA00010199}.
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DR   EMBL; FXAZ01000001; SMG23148.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1X7J6W7; -.
DR   STRING; 1852522.SAMN06295960_1275; -.
DR   OrthoDB; 9776324at2; -.
DR   Proteomes; UP000193834; Unassembled WGS sequence.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR   GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-KW.
DR   GO; GO:0042910; F:xenobiotic transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0006811; P:monoatomic ion transport; IEA:UniProtKB-KW.
DR   CDD; cd13140; MATE_like_1; 1.
DR   InterPro; IPR002528; MATE_fam.
DR   InterPro; IPR048279; MdtK-like.
DR   NCBIfam; TIGR00797; matE; 1.
DR   PANTHER; PTHR43298:SF2; FMN_FAD EXPORTER YEEO-RELATED; 1.
DR   PANTHER; PTHR43298; MULTIDRUG RESISTANCE PROTEIN NORM-RELATED; 1.
DR   Pfam; PF01554; MatE; 2.
DR   PIRSF; PIRSF006603; DinF; 1.
PE   3: Inferred from homology;
KW   Antiport {ECO:0000256|ARBA:ARBA00022449};
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000193834};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT   TRANSMEM        21..42
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        48..71
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        92..113
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        133..155
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        167..188
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        194..217
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        238..263
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        283..305
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        317..337
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        357..378
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        390..409
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        415..433
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
SQ   SEQUENCE   447 AA;  48574 MW;  7473BF925D2F953B CRC64;
     MKGTTDLTQG KIMPTLMKLT LPIIATNFIS TTYGLIDMIW VGRLGSGPVA AIGTASFFIN
     LAIALSTMIT IGTGIKVSHC MGAGEGDKAK TYIKNGFMLS VLLGLLYTAF VFLTKDQLIG
     FFDLGSDEVE LMAKQFLLIS ILGTIFSVVN TLFATIMNAR GNSKQPFHIF TVGLVFNIIL
     DPILIFGVGR LEGLGVAGAA IATLTANLLV TVLFIIQTRH SELIAKSSAW NSLLMKEVIV
     MGLPITIQRV TFTLISIIIA KIIVRFGSDA IAVQKVGIQI ESISYMTIGG LQGAIAAFFG
     QNYGARRLDR IQQGYRQALL LTTGFGIVIS LLFIIFPEQL FSVFLSDEAS LALGTDYMRI
     IGYSQLFMCM ELMTVGAFNG IGKTHIPPMF SITFTALRIP LALILSEPFG LNGVWMSIAL
     SSVFKGLVLV FWFRRSLHNM KVQQTVA
//