ID A0A1X7JDS8_9BURK Unreviewed; 378 AA.
AC A0A1X7JDS8;
DT 05-JUL-2017, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2017, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE RecName: Full=3-hydroxyisobutyryl-CoA hydrolase {ECO:0000256|ARBA:ARBA00011915};
DE EC=3.1.2.4 {ECO:0000256|ARBA:ARBA00011915};
GN ORFNames=SAMN06265784_102467 {ECO:0000313|EMBL:SMG25764.1};
OS Paraburkholderia susongensis.
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC Burkholderiaceae; Paraburkholderia.
OX NCBI_TaxID=1515439 {ECO:0000313|EMBL:SMG25764.1, ECO:0000313|Proteomes:UP000193228};
RN [1] {ECO:0000313|Proteomes:UP000193228}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LMG 29540 {ECO:0000313|Proteomes:UP000193228};
RA Varghese N., Submissions S.;
RL Submitted (APR-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=3-hydroxy-2-methylpropanoyl-CoA + H2O = 3-hydroxy-2-
CC methylpropanoate + CoA + H(+); Xref=Rhea:RHEA:20888,
CC ChEBI:CHEBI:11805, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:57287, ChEBI:CHEBI:57340; EC=3.1.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00001709};
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DR EMBL; FXAT01000002; SMG25764.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1X7JDS8; -.
DR STRING; 1515439.SAMN06265784_102467; -.
DR OrthoDB; 9790967at2; -.
DR Proteomes; UP000193228; Unassembled WGS sequence.
DR GO; GO:0003860; F:3-hydroxyisobutyryl-CoA hydrolase activity; IEA:InterPro.
DR CDD; cd06558; crotonase-like; 1.
DR InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR InterPro; IPR045004; ECH_dom.
DR InterPro; IPR032259; HIBYL-CoA-H.
DR PANTHER; PTHR43176:SF3; 3-HYDROXYISOBUTYRYL-COA HYDROLASE, MITOCHONDRIAL; 1.
DR PANTHER; PTHR43176; 3-HYDROXYISOBUTYRYL-COA HYDROLASE-RELATED; 1.
DR Pfam; PF16113; ECH_2; 1.
DR SUPFAM; SSF52096; ClpP/crotonase; 1.
PE 4: Predicted;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801}.
FT DOMAIN 21..362
FT /note="Enoyl-CoA hydratase/isomerase"
FT /evidence="ECO:0000259|Pfam:PF16113"
SQ SEQUENCE 378 AA; 41447 MW; 4A76F4757BA835E7 CRC64;
MSISASPAAS DEVATYVANR IGFIELERPK ALNALSTGMI RVMHAALDQW REDPEVLAVV
VRSPHARAFC AGGDIRLMYE AAQRGDQDSR DTFFTEEYRL NHAIFTYPKP YIALMHGIVM
GGGMGISQGA HRTGGLRVVT QSTKMAMPET RIGLFPDVGA SWFLARTPGA IGRYLAVTGE
TIGAADALYA GLADVYIDDE ALPALLDTLR REPFERGADV VACIEREARA YQVAPLPEES
ALAGARTLLD RHFALPDVAR ILASLEEEHE RGDDAAEWAE QTIAVLRERS PLSMAVSLEV
VTRAEGSMAD VLRADLDLTR SSFLIGDTVE GIRARIIDKD NAPRWRFARI EDVSAADVEK
MFDSPWPANE HPLRDLRG
//
