ID A0A1X7JRH6_9BACT Unreviewed; 461 AA.
AC A0A1X7JRH6;
DT 05-JUL-2017, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2017, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE RecName: Full=mannose-1-phosphate guanylyltransferase {ECO:0000256|ARBA:ARBA00012387};
DE EC=2.7.7.13 {ECO:0000256|ARBA:ARBA00012387};
GN ORFNames=SAMN06275492_11466 {ECO:0000313|EMBL:SMG30118.1};
OS Dethiosulfovibrio salsuginis.
OC Bacteria; Synergistota; Synergistia; Synergistales;
OC Dethiosulfovibrionaceae; Dethiosulfovibrio.
OX NCBI_TaxID=561720 {ECO:0000313|EMBL:SMG30118.1, ECO:0000313|Proteomes:UP000193355};
RN [1] {ECO:0000313|EMBL:SMG30118.1, ECO:0000313|Proteomes:UP000193355}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=USBA 82 {ECO:0000313|EMBL:SMG30118.1,
RC ECO:0000313|Proteomes:UP000193355};
RA Afonso C.L., Miller P.J., Scott M.A., Spackman E., Goraichik I.,
RA Dimitrov K.M., Suarez D.L., Swayne D.E.;
RL Submitted (APR-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=alpha-D-mannose 1-phosphate + GTP + H(+) = diphosphate + GDP-
CC alpha-D-mannose; Xref=Rhea:RHEA:15229, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:33019, ChEBI:CHEBI:37565, ChEBI:CHEBI:57527,
CC ChEBI:CHEBI:58409; EC=2.7.7.13;
CC Evidence={ECO:0000256|ARBA:ARBA00001083};
CC -!- SIMILARITY: Belongs to the mannose-6-phosphate isomerase type 2 family.
CC {ECO:0000256|ARBA:ARBA00006115, ECO:0000256|RuleBase:RU004190}.
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DR EMBL; FXBB01000014; SMG30118.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1X7JRH6; -.
DR STRING; 561720.SAMN06275492_11466; -.
DR OrthoDB; 9806359at2; -.
DR Proteomes; UP000193355; Unassembled WGS sequence.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0016853; F:isomerase activity; IEA:UniProtKB-KW.
DR GO; GO:0004475; F:mannose-1-phosphate guanylyltransferase (GTP) activity; IEA:UniProtKB-EC.
DR GO; GO:0000271; P:polysaccharide biosynthetic process; IEA:InterPro.
DR CDD; cd02213; cupin_PMI_typeII_C; 1.
DR CDD; cd02509; GDP-M1P_Guanylyltransferase; 1.
DR Gene3D; 2.60.120.10; Jelly Rolls; 1.
DR InterPro; IPR049577; GMPP_N.
DR InterPro; IPR006375; Man1P_GuaTrfase/Man6P_Isoase.
DR InterPro; IPR001538; Man6P_isomerase-2_C.
DR InterPro; IPR005835; NTP_transferase_dom.
DR InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR InterPro; IPR014710; RmlC-like_jellyroll.
DR InterPro; IPR011051; RmlC_Cupin_sf.
DR NCBIfam; TIGR01479; GMP_PMI; 1.
DR PANTHER; PTHR46390; MANNOSE-1-PHOSPHATE GUANYLYLTRANSFERASE; 1.
DR PANTHER; PTHR46390:SF1; MANNOSE-1-PHOSPHATE GUANYLYLTRANSFERASE; 1.
DR Pfam; PF01050; MannoseP_isomer; 1.
DR Pfam; PF00483; NTP_transferase; 1.
DR SUPFAM; SSF53448; Nucleotide-diphospho-sugar transferases; 1.
DR SUPFAM; SSF51182; RmlC-like cupins; 1.
PE 3: Inferred from homology;
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Isomerase {ECO:0000313|EMBL:SMG30118.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 10..281
FT /note="Nucleotidyl transferase"
FT /evidence="ECO:0000259|Pfam:PF00483"
FT DOMAIN 312..461
FT /note="Mannose-6-phosphate isomerase type II C-terminal"
FT /evidence="ECO:0000259|Pfam:PF01050"
SQ SEQUENCE 461 AA; 51040 MW; 437FCDBA16A29DCC CRC64;
MNNDIKKLRA LILAGGGGTR LWPLSREEVP KQFLKLAGDQ SLLQTTIKRL LPLCGQEGIK
IVAGERWDSQ IAYQASDVGL KGDILVLEPE GKNTAPAIAL GLAHLMEKGA TRETPVLVCP
SDHIIQNEKA FHDALKLGLL ALEEGKLVTF GIVPDAPETG FGYIKKGEDR GGWHDVSQFV
EKPDLKKATE YIQSGQYLWN GGIFLFRAGD MIDSFKEHLP EIARLMECGE RAMVEGFKDL
PSVSIDYGIM EKAPSVAVVP LDACWSDLGS WDAIYQQGEK DGNRNVLKGD VLADRSEGCL
VQGDRRLIAL SGVSDLLVVD TADALFIAPR GTSQSVKDVV STLKERSRPE ITQAPESARR
WGDYRILHEG DGIKVKRITV HPGKALSLQY HHHRTEHWIV VKGTAQVERD GETFYLHEGE
STFIQKNQLH RLINPGKISL EIIEVQNGPY LGEDDIFRVE E
//
