ID   A0A1X7K5P3_9RHOB        Unreviewed;      1833 AA.
AC   A0A1X7K5P3;
DT   05-JUL-2017, integrated into UniProtKB/TrEMBL.
DT   05-JUL-2017, sequence version 1.
DT   27-MAR-2024, entry version 25.
DE   RecName: Full=Apple domain-containing protein {ECO:0008006|Google:ProtNLM};
GN   ORFNames=SAMN02746000_02175 {ECO:0000313|EMBL:SMG36324.1};
OS   Paracoccus sp. J56.
OC   Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodobacterales;
OC   Paracoccaceae; Paracoccus.
OX   NCBI_TaxID=935850 {ECO:0000313|EMBL:SMG36324.1, ECO:0000313|Proteomes:UP000193912};
RN   [1] {ECO:0000313|Proteomes:UP000193912}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=J56 {ECO:0000313|Proteomes:UP000193912};
RA   Varghese N., Submissions S.;
RL   Submitted (APR-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the protease inhibitor I39 (alpha-2-
CC       macroglobulin) family. Bacterial alpha-2-macroglobulin subfamily.
CC       {ECO:0000256|ARBA:ARBA00010556}.
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DR   EMBL; FXAQ01000012; SMG36324.1; -; Genomic_DNA.
DR   STRING; 935850.SAMN02746000_02175; -.
DR   Proteomes; UP000193912; Unassembled WGS sequence.
DR   GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR   GO; GO:0004866; F:endopeptidase inhibitor activity; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR   CDD; cd02891; A2M_like; 1.
DR   CDD; cd01100; APPLE_Factor_XI_like; 1.
DR   Gene3D; 1.50.10.20; -; 1.
DR   Gene3D; 2.60.40.1930; -; 1.
DR   Gene3D; 3.50.4.10; Hepatocyte Growth Factor; 1.
DR   InterPro; IPR026284; A2-macglob_dom_prot_bac.
DR   InterPro; IPR011625; A2M_N_BRD.
DR   InterPro; IPR047565; Alpha-macroglob_thiol-ester_cl.
DR   InterPro; IPR011626; Alpha-macroglobulin_TED.
DR   InterPro; IPR021868; Alpha_2_Macroglob_MG3.
DR   InterPro; IPR000177; Apple.
DR   InterPro; IPR041203; Bact_A2M_MG5.
DR   InterPro; IPR041462; Bact_A2M_MG6.
DR   InterPro; IPR041246; Bact_MG10.
DR   InterPro; IPR001599; Macroglobln_a2.
DR   InterPro; IPR002890; MG2.
DR   InterPro; IPR003609; Pan_app.
DR   InterPro; IPR008930; Terpenoid_cyclase/PrenylTrfase.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   PANTHER; PTHR40094; ALPHA-2-MACROGLOBULIN HOMOLOG; 1.
DR   PANTHER; PTHR40094:SF1; UBIQUITIN DOMAIN-CONTAINING PROTEIN; 1.
DR   Pfam; PF00207; A2M; 1.
DR   Pfam; PF07703; A2M_BRD; 1.
DR   Pfam; PF17973; bMG10; 1.
DR   Pfam; PF11974; bMG3; 1.
DR   Pfam; PF17972; bMG5; 1.
DR   Pfam; PF17962; bMG6; 1.
DR   Pfam; PF01835; MG2; 1.
DR   Pfam; PF00024; PAN_1; 1.
DR   Pfam; PF07678; TED_complement; 1.
DR   PIRSF; PIRSF038980; A2M_bac; 1.
DR   SMART; SM01360; A2M; 1.
DR   SMART; SM01359; A2M_N_2; 1.
DR   SMART; SM01419; Thiol-ester_cl; 1.
DR   SUPFAM; SSF48239; Terpenoid cyclases/Protein prenyltransferases; 1.
DR   SUPFAM; SSF48452; TPR-like; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000193912}.
FT   DOMAIN          967..1112
FT                   /note="Alpha-2-macroglobulin bait region"
FT                   /evidence="ECO:0000259|SMART:SM01359"
FT   DOMAIN          1175..1263
FT                   /note="Alpha-2-macroglobulin"
FT                   /evidence="ECO:0000259|SMART:SM01360"
FT   REGION          1148..1167
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1833 AA;  194504 MW;  AE57FE7E2423B9C8 CRC64;
     MAYLVRQGLF AAILGGLIVS GSAWAQDWQI PDRRLSLQPD TDLPGGDLGP IFDTTLQACV
     QACLANADCR ALTYNERAGA CFPKGADTGA PTAFVGAISG RVVATSAEER LRAESRSAAA
     PFIAATDHEA ARNQARTFPA MHPAIGPSAT AQMAVEAENG GGLLYASQLM ASLVARDDRA
     EDWTNLARLT LYISDQGDRQ ASSSIANMAI NGYLRAGEDA VAARALSWLA MAWERLDRGR
     DALAALRLAA KLSPGDGSIA QALEESEARN GMRITNTQIE AEGRMPRFCA IMSHKLSEAT
     DYAQFLRLPG RDLTVEASGD RLCVAGLTHG QEVELTLRAG LPSADGEALA RDVTLKGYVR
     DRAPSVRFPG RAYVLPASGD QRLSMVTVNA DTISLRLLRI SDRNLIRAMA EDMFATPLDS
     WQADYFSDRM SREIWKGTAQ VARPMGQQTM NQELTTSLAI PAEVGPLEPG IYILEAGIEN
     ESVQDTGLAT QWFVISDFGI STFSGADGLT VAVRSLADTS AKAGAEVALI SRSNEVLAKT
     VTDDQGVAHF APGLALGKEG AAPALVTVTE WQGDGAERAP RDMAFLSLSD PEFDLSDRGV
     EGQPPAPPID LFVTTDRGAY RVGETVNATI LARNAETRAL ENLPLTAVIL RPDGVEATRL
     PAQDAGAGGS TVNWQIPGNA PRGTWRLELR TEADGPALAT ARILVEDFLP ERIDFTLRLP
     EGPARAGDQL DLSLSAHWLF GAPAGNLPVE GQLRLSPTRS LQGFDGYVFG RHDDDTAPVT
     ESLPAGVTEA QGGYETQIPL PEAEQLGARP VQAEVVVDIR EGAGRPVERT ESRIVMPEAP
     VVGIRPMFEG DTVSEGTEAR FALMAVGPDL KPEAQPVRWV LNRIDTEYQW YSLGGQWNWE
     VITSRTRITE GVAEPGESPA EISAPVEWGE YELVAELASG QGGPSSARFY AGWGAIANSG
     TETPDRLKVV LDKPAYRSGD TARVRVEAAS DGLGLVSVLS NRLVSMQTVA LKAGDNTVDL
     PVTDEWGAGV YITVSAIRPL GDTKPGDRQP VRALGLAHAA VDPGDRQLAA SFEAPAETRP
     RGVIPVTLKV DGAAGETVHA TIAAVDQGIL NLTRFQPPNP SQHYFGQRRL GVALRDLYGR
     LIMPTGAPDG ALREGGDANL AGSTEAPPPT EKLMSWFSGP VTVGADGNVT VEIPVGDFNG
     EVRLMAVVWS TKGVGQTDAS VLVRDPVVMT VTAPAFLAPG DRAQVGLRLT HASGPAGEVR
     LAVEQVSGSA PLTTSLPVDS VTLAEKAEAQ VQMPVTAGEA EGIANLRLTL TTPDGEALTK
     DIAIPVSLNE ADIQRQDRLV IEPGQSLTIP PTLMQSMLPG AEVTAALGPY GRLDVAGALM
     RLARYPYGCT EQLTSGAMPL LYLPSLAAAE GMEGEDTSKQ VQRAIDQILT RQSSNGGFGL
     WYADSGDLWL ESYVTDFLSR ARAAGYRVPD TAFDMAINNL RNRANYATEP GAASADENAA
     LAYALTVLAR ERAATVGDLR YYADTAAGSF STPMAAANLG AALASYGDQQ RADRMFTQAH
     NLLNLGAPEA YSYRADYGTK LRDGSAVLAL AAEAKTQAID TTDLSGQIAQ RIAHAEEAGR
     SLSTQEAVWT VLAAQSLFSS TPAATLNGVA LNQPVVNLPA DASIANNGDR PLEVTLTATG
     KPQGPVAAGG KGYTISRSYF SMEGSPLDPE TVKQGTRMVV VVEVYPHSEG GGRLVIADPL
     PAGWEIDNPN LLRAGDVSSL DWLEAETSTE MSEFRADRFA AALTWTSAES FKLAYIVRAV
     TPGDFRQPAA SVEDMYRPEY RAWSDSGTVT VTP
//