ID A0A1X7KPB8_9RHOB Unreviewed; 1126 AA.
AC A0A1X7KPB8;
DT 05-JUL-2017, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2017, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
DE AltName: Full=DNA 3'-5' helicase II {ECO:0000256|ARBA:ARBA00034923};
GN ORFNames=SAMN02746000_02600 {ECO:0000313|EMBL:SMG43074.1};
OS Paracoccus sp. J56.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodobacterales;
OC Paracoccaceae; Paracoccus.
OX NCBI_TaxID=935850 {ECO:0000313|EMBL:SMG43074.1, ECO:0000313|Proteomes:UP000193912};
RN [1] {ECO:0000313|Proteomes:UP000193912}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=J56 {ECO:0000313|Proteomes:UP000193912};
RA Varghese N., Submissions S.;
RL Submitted (APR-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
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DR EMBL; FXAQ01000016; SMG43074.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1X7KPB8; -.
DR STRING; 935850.SAMN02746000_02600; -.
DR Proteomes; UP000193912; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-UniRule.
DR Gene3D; 3.90.320.10; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 4.
DR InterPro; IPR014151; DNA_helicase_AddA.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011604; PDDEXK-like_dom_sf.
DR InterPro; IPR038726; PDDEXK_AddAB-type.
DR InterPro; IPR011335; Restrct_endonuc-II-like.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR NCBIfam; TIGR02784; addA_alphas; 1.
DR PANTHER; PTHR11070:SF2; ATP-DEPENDENT DNA HELICASE SRS2; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF12705; PDDEXK_1; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR Pfam; PF13361; UvrD_C; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52980; Restriction endonuclease-like; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Exonuclease {ECO:0000256|ARBA:ARBA00022839};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Reference proteome {ECO:0000313|Proteomes:UP000193912}.
FT DOMAIN 2..467
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT DOMAIN 492..768
FT /note="UvrD-like helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51217"
FT REGION 485..521
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 901..924
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 23..30
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 1126 AA; 122302 MW; 453CBFA9D7D7F1AB CRC64;
MMDEATLAQV RAADPHRSTW LTANAGSGKT RVLTDRVARL LLAGTAPERI LCLTYTKAAA
TEMQNRLLSR LGKWAMLPEA DLRAELARLG EAGAPDLPAA RRLFARAIET PGGLKVQTIH
SFCAGVLRRF PIEAGVPHGF TELDDRSAAL IRAEIIEEMA RDQVPELQDL LLLHSGDKLD
AFLAGLRGFD APADRDTLWA ASGLEPGEDM QALLAECFAD GAMVIPALIP HLLKGRSTDQ
KAAEKLMPGN WTQPGLAELA ILESVLLTGA GAKQPFSAKY DSFPTKDLRN GPCAGLIDDL
AILMERVEAA RPRRVALTHA ERTLALHRFG HAFLTRYRAH KAAHGHLDFD DLIERTARLL
SENSMAQWVL FRLDGGIDHI LVDEAQDTSP AQWQVIERLT DEFTSGQGAR TDRRSLFVVG
DPKQSIYSFQ GADIAVFEAR RAGFAEAFEA VQNPMQMLEL RHSFRSSTAI LSLVDQVFAG
DAARGLGDPP QHRAFRDKMP GRVDLWPPIP KPEKPEPGDW TAPVDQPAEN SETVQLARAI
AAAVGDMLGQ PIFDAKIGRA RRIRAGDVLI LVQRRSELFA EIIAALKAAA LPVAGADRLK
LAGELAVRDI RALLSVLATP EDDLSLAACL RSPLFGLSEE ELYRLASGRK RGEYLWRRLR
ESQHRHAVEV LSDLMGQTGF MRPYDLIQRL LIRHGGRERL IARLGPEAED GIDELLSQAL
SYESMETPSL TGFLVWLTGG DVEVRRQAGS AGDGEGLIRV MTVHGSKGLE SPIVIMPDCA
TRRAPREMPV LVGPDGLALW RGRNGERPEP VEELAALQTE RQLQERKRLL YVGLTRAESW
LIVAAAGDTG VGEDSWHAMV EAGMGRSDLT QTRLPAPWGG EIRRLSFGDW PENAPEAIRE
SRAPLDEPQW LRSSPPPAPP KARPVAATAL GGAKVIGTPG DGDGDAEAAM LAGTRLHLLL
EHLPDRDPSD WPGVARDVLA DAEGGLPGPE EMSALLDEVR AVIEAPDLAQ VFALSDKAEV
LTEVALAADI PGIGTLTGAV DRLVIEPGRI VAVDYKSNRE VPDRPEAVPL GILRQMAAYR
AALRQIWPDA QVGVAVLWTV ARSLMVLPDA LLDRVMAGLD PGTDGA
//
