ID A0A1X7L2W5_9MICO Unreviewed; 848 AA.
AC A0A1X7L2W5;
DT 05-JUL-2017, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2017, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=histidine kinase {ECO:0000256|ARBA:ARBA00012438};
DE EC=2.7.13.3 {ECO:0000256|ARBA:ARBA00012438};
GN ORFNames=SAMN06296010_3273 {ECO:0000313|EMBL:SMG48196.1};
OS Agreia pratensis.
OC Bacteria; Actinomycetota; Actinomycetes; Micrococcales; Microbacteriaceae;
OC Agreia.
OX NCBI_TaxID=150121 {ECO:0000313|EMBL:SMG48196.1, ECO:0000313|Proteomes:UP000193244};
RN [1] {ECO:0000313|EMBL:SMG48196.1, ECO:0000313|Proteomes:UP000193244}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=VKM Ac-2510 {ECO:0000313|EMBL:SMG48196.1,
RC ECO:0000313|Proteomes:UP000193244};
RA Afonso C.L., Miller P.J., Scott M.A., Spackman E., Goraichik I.,
RA Dimitrov K.M., Suarez D.L., Swayne D.E.;
RL Submitted (APR-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC histidine.; EC=2.7.13.3; Evidence={ECO:0000256|ARBA:ARBA00000085};
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DR EMBL; FXAY01000007; SMG48196.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1X7L2W5; -.
DR STRING; 150121.SAMN06296010_3273; -.
DR OrthoDB; 9806130at2; -.
DR Proteomes; UP000193244; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR CDD; cd00075; HATPase; 1.
DR CDD; cd00082; HisKA; 1.
DR CDD; cd01987; USP_OKCHK; 1.
DR Gene3D; 1.10.287.130; -; 1.
DR Gene3D; 1.20.120.620; Backbone structure of the membrane domain of e. Coli histidine kinase receptor kdpd; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR Gene3D; 3.40.50.620; HUPs; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR003594; HATPase_C.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR005467; His_kinase_dom.
DR InterPro; IPR003661; HisK_dim/P.
DR InterPro; IPR036097; HisK_dim/P_sf.
DR InterPro; IPR038318; KdpD_sf.
DR InterPro; IPR025201; KdpD_TM.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR InterPro; IPR004358; Sig_transdc_His_kin-like_C.
DR InterPro; IPR003852; Sig_transdc_His_kinase_KdpD_N.
DR InterPro; IPR006016; UspA.
DR PANTHER; PTHR45569; SENSOR PROTEIN KDPD; 1.
DR PANTHER; PTHR45569:SF1; SENSOR PROTEIN KDPD; 1.
DR Pfam; PF13493; DUF4118; 1.
DR Pfam; PF02518; HATPase_c; 1.
DR Pfam; PF00512; HisKA; 1.
DR Pfam; PF02702; KdpD; 1.
DR Pfam; PF00582; Usp; 1.
DR PRINTS; PR00344; BCTRLSENSOR.
DR SMART; SM00387; HATPase_c; 1.
DR SMART; SM00388; HisKA; 1.
DR SUPFAM; SSF52402; Adenine nucleotide alpha hydrolases-like; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF47384; Homodimeric domain of signal transducing histidine kinase; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS50109; HIS_KIN; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:SMG48196.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW Two-component regulatory system {ECO:0000256|ARBA:ARBA00023012}.
FT TRANSMEM 379..397
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 409..436
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 456..479
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 627..841
FT /note="Histidine kinase"
FT /evidence="ECO:0000259|PROSITE:PS50109"
SQ SEQUENCE 848 AA; 89528 MW; D980E02A808D026F CRC64;
MGRGRLRVLL GAAPGVGKTY TMLEEGARLA AEGRDVVVAV VETHGRSATA RMLADLEVVP
RLSVTHRGVT LSEMDLDAVL ERRPNVALVD ELAHSNAPGS RHEKRWQDVE TLLDAGIDVM
TTVNIQHIES LTDVVEQITG ARQQETVPDG VVRSADQLEV VDLAPQALRD RLADGRVYPA
ARIDAALSNY FRLGNLTALR ELALLWLADE VDSALKSYRA DHGIASKWEA RERVVVALTG
GPEGETLLKR GARIAARSAG GTLVAVHVTS QDGLRAAHPG ALAAQRSLVE SLGGTFHQVV
GDDIPAALVD YARGVNATQL VIGVSRRTRL SAALSGPGIG ATVIRASGDI DVHIVTHAAA
GGKLRLPRFS GSLTARRRVL GFVLALGGGP LVTWLLVTLR SDESITSDVL TFQLLVVLVA
LVGGIWPALF AALLSGLTLD FFFVSPLYTV SVGEPLHLLA LALYVVNAVL VSVVVDTAAR
RSRQARRAAA ESELLASIAG SVLRGQDALQ ALVDRTREAF RLNEVRLKAL DGSILASSTM
SDYEAEAGFE TATETETAAR AASTIAVGER ATLELCGPDL AASERRLLGV IAAQMDQALE
HRDLAATASE VGPLAVADRM RSALLAAVGH DLRRPLTAAT AAVSGLRSTE VELSSHDRTE
LLDTAQESLD SLADLVTDLL DVSRVEAGVL AVSMHAIDVE DVIVPALDEL ELGPDRVELA
LDGDERPPVL ADEVLLQRVL VNLLSNAVRF SPEGAKVRLS ASAFRGRVEL RVVDSGPGVP
GERRDEIFVP FQRLGDTDNS TGLGLGLALS KGFVEGMGGT IEAEDTPGGG LTMVVSLPAA
DPAVEETS
//
