ID A0A1X7L367_9RHOB Unreviewed; 1184 AA.
AC A0A1X7L367;
DT 05-JUL-2017, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2017, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE RecName: Full=site-specific DNA-methyltransferase (adenine-specific) {ECO:0000256|ARBA:ARBA00011900};
DE EC=2.1.1.72 {ECO:0000256|ARBA:ARBA00011900};
GN ORFNames=SAMN02746000_02967 {ECO:0000313|EMBL:SMG48190.1};
OS Paracoccus sp. J56.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodobacterales;
OC Paracoccaceae; Paracoccus.
OX NCBI_TaxID=935850 {ECO:0000313|EMBL:SMG48190.1, ECO:0000313|Proteomes:UP000193912};
RN [1] {ECO:0000313|Proteomes:UP000193912}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=J56 {ECO:0000313|Proteomes:UP000193912};
RA Varghese N., Submissions S.;
RL Submitted (APR-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an
CC N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-
CC homocysteine; Xref=Rhea:RHEA:15197, Rhea:RHEA-COMP:12418, Rhea:RHEA-
CC COMP:12419, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:90615, ChEBI:CHEBI:90616; EC=2.1.1.72;
CC Evidence={ECO:0000256|ARBA:ARBA00001279};
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DR EMBL; FXAQ01000022; SMG48190.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1X7L367; -.
DR STRING; 935850.SAMN02746000_02967; -.
DR Proteomes; UP000193912; Unassembled WGS sequence.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0009007; F:site-specific DNA-methyltransferase (adenine-specific) activity; IEA:UniProtKB-EC.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR047939; BREX_1_PglX.
DR InterPro; IPR002052; DNA_methylase_N6_adenine_CS.
DR InterPro; IPR046816; MmeI_Mtase.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR NCBIfam; NF033452; BREX_1_MTaseX; 1.
DR PANTHER; PTHR33841:SF1; ADENINE-SPECIFIC METHYLTRANSFERASE PGLX; 1.
DR PANTHER; PTHR33841; DNA METHYLTRANSFERASE YEEA-RELATED; 1.
DR Pfam; PF20473; MmeI_Mtase; 1.
DR PRINTS; PR00507; N12N6MTFRASE.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS00092; N6_MTASE; 1.
PE 4: Predicted;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000313|EMBL:SMG48190.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000193912};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 283..520
FT /note="MmeI-like DNA-methyltransferase"
FT /evidence="ECO:0000259|Pfam:PF20473"
SQ SEQUENCE 1184 AA; 133758 MW; BC66FBD8C4622BCC CRC64;
MDTNALKKFA QSARNLLIDQ VTARLDMVLA EGAAARREHP KAIARLEAAA NSNRAQVIEQ
AAYTWFNRFS ALRFMDATGL TNPRVVSPAD GATRPEILAE AMAGNLPNRA RPEIAEYLNG
TRPAHDGQAE AYRLLLIHAC NEWHGAMPYM FERADMLDRA EDYTELLMPD DLLSLDSILA
RLREMMTEDA CQDVEIIGWL YQFYISEKKD QVFAGLKKNQ KITAENIPAA TQLFTPHWIV
RYLVENSLGR LWLLNRPQSK LAAKMDYYIA PEEPETDFLK ITRPEEIRIC DPACGSGHML
TYAFDLLYEI YAEEGHDAAE IPGLILQHNL TGIEIDDRAG ALAAFALSMK AAAKLGRRRF
LRMEEKPDIV VLQDVRFTPA EVQDVAAVVG KDLFTDELRE TLGQFEPAKN FGSLIVPKLR
DPAETLRVAK ARDFGSDLLL KEVQARVVAV LRMAEALSPK YHVVVANPPY MGGGGMNSKL
QEFAKSFYAD SKSDLYAIFM ERAVSLTAES GIVAMVNMQS WMFLPYFEAL RSKLFSHSHL
LTMAHLGPRA FDSIGGDVVS TTAFCLQNSR KMDHSALFVR LIDGRDEREK SEKLKSIASG
STIDGKYYAS QNQIEHLPGK PIAYWLGKNF LEAFARSERL GDVFPTRTGL QTGDNAKFVR
IWHEVEHSKS SLEPLDPETS RASAYKWFPL NAGGTYRRWF GNNEKVVDWL NDGENIRNDK
LERLERGEIL ASNSKPKNEQ YYFLPAVTWT RIKSKSFGVR ICEQGTIFDM AGSSVFPGAS
NLSIVSAFLN SKICDFALGA INPTVTTQPG DVARFPWLVE AVQNSKAKIR RVAETALLTA
KSDWDASETS WDFTTFPLLS PDHRAETLAD TYANLRTHWQ GMTDKMQRLE EENNRIFIDA
YGLADELTPE VAIEEVTLTC NPAYRYGVKG TEEDREARLR EDTVAEFLHF AVGCMFGRYS
LDVPGLILAN QGEGIEEYLA RVPEPSFAPD RDNVIPVLDA DWFADDVVTR ARDFLRVTFG
EAKFRENLAF VEAALGKDLR KWFTRDFFDY HVRRYKKRPI YWMFSSPKGS FNALIYMHRY
RPDTVSVVLN QYVREFIHKL EVERTRLEKL AVDPAATPAQ QTKAQKETAT VIKQIAELTE
WEREVVYPMA QQKIAIDLDD GVKRNYPLFA GALKPIKGLE AADD
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