ID A0A1X7L9K6_9BURK Unreviewed; 794 AA.
AC A0A1X7L9K6;
DT 05-JUL-2017, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2017, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=DNA polymerase {ECO:0000256|RuleBase:RU000442};
DE EC=2.7.7.7 {ECO:0000256|RuleBase:RU000442};
GN ORFNames=SAMN06265784_105291 {ECO:0000313|EMBL:SMG50501.1};
OS Paraburkholderia susongensis.
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC Burkholderiaceae; Paraburkholderia.
OX NCBI_TaxID=1515439 {ECO:0000313|EMBL:SMG50501.1, ECO:0000313|Proteomes:UP000193228};
RN [1] {ECO:0000313|Proteomes:UP000193228}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LMG 29540 {ECO:0000313|Proteomes:UP000193228};
RA Varghese N., Submissions S.;
RL Submitted (APR-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC ChEBI:CHEBI:173112; EC=2.7.7.7;
CC Evidence={ECO:0000256|ARBA:ARBA00024632,
CC ECO:0000256|RuleBase:RU000442};
CC -!- SIMILARITY: Belongs to the DNA polymerase type-B family.
CC {ECO:0000256|ARBA:ARBA00005755, ECO:0000256|RuleBase:RU000442}.
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DR EMBL; FXAT01000005; SMG50501.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1X7L9K6; -.
DR STRING; 1515439.SAMN06265784_105291; -.
DR OrthoDB; 5807460at2; -.
DR Proteomes; UP000193228; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR CDD; cd05784; DNA_polB_II_exo; 1.
DR CDD; cd05537; POLBc_Pol_II; 1.
DR Gene3D; 2.40.50.590; -; 2.
DR Gene3D; 6.10.140.1130; -; 1.
DR Gene3D; 1.10.132.60; DNA polymerase family B, C-terminal domain; 1.
DR Gene3D; 1.10.287.690; Helix hairpin bin; 1.
DR Gene3D; 3.90.1600.10; Palm domain of DNA polymerase; 1.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR InterPro; IPR006172; DNA-dir_DNA_pol_B.
DR InterPro; IPR017964; DNA-dir_DNA_pol_B_CS.
DR InterPro; IPR006133; DNA-dir_DNA_pol_B_exonuc.
DR InterPro; IPR006134; DNA-dir_DNA_pol_B_multi_dom.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR042087; DNA_pol_B_thumb.
DR InterPro; IPR023211; DNA_pol_palm_dom_sf.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR PANTHER; PTHR10322; DNA POLYMERASE CATALYTIC SUBUNIT; 1.
DR PANTHER; PTHR10322:SF23; DNA POLYMERASE DELTA CATALYTIC SUBUNIT; 1.
DR Pfam; PF00136; DNA_pol_B; 1.
DR Pfam; PF03104; DNA_pol_B_exo1; 1.
DR Pfam; PF21474; DNApolII_N; 1.
DR PRINTS; PR00106; DNAPOLB.
DR SMART; SM00486; POLBc; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR PROSITE; PS00116; DNA_POLYMERASE_B; 1.
PE 3: Inferred from homology;
KW DNA replication {ECO:0000256|RuleBase:RU000442};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU000442};
KW DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932,
KW ECO:0000256|RuleBase:RU000442};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695,
KW ECO:0000256|RuleBase:RU000442};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU000442}.
FT DOMAIN 76..305
FT /note="DNA-directed DNA polymerase family B exonuclease"
FT /evidence="ECO:0000259|Pfam:PF03104"
FT DOMAIN 387..769
FT /note="DNA-directed DNA polymerase family B
FT multifunctional"
FT /evidence="ECO:0000259|Pfam:PF00136"
SQ SEQUENCE 794 AA; 90890 MW; 581E5EF37090AF75 CRC64;
MTEFEQGFIL TRHWRDTPAG TEIEFWLATD SGPRHIRLRP QPSVAFIPAE HRERAETILR
DEKQYDLRPL ELCDFQHRPV MGLYCPQYRQ LKSFEKRLKQ GDVDVYEADI QPHERYMMER
FITAPVWFSG EPQQKGPLSN GELKPASGYR PPLKLVSLDI ETSAHAELYS IALEGCGERQ
VYMLGPPNGV DGGDGDGSSL DFKLEYCETR AQLLEKLIEW MERHDPDAII GWNLVQFDLK
VLQQHSEQYR VPLRIGRGGA VMEWREHSVT RNHFFAGAAG RLIIDGIEAL RSATWSFPSF
SLEYVSRSVL GEGKAIDNPY QRMDEIQRRF DEAKPELARY NLKDCELVTR IFAKTELLPF
LLERANVTGL PADRSGGSVA AFTHLYMPRM HRQGYVAPNL GDVAGAASPG GFVMDSRPGL
YDSVLVLDYK SLYPSIIRTF LIDPLGLVEG MLHPDDEHSV PGFLGARFSR TRHCLPSVVA
QVWQARETAK REHDKPLSQA LKIIMNAFYG VLGSTGCRFF DPRLASSITM RGHEIMHTTR
ELIEAQGYEV IYGDTDSTFV WLKHAHSEDD AARVGRALVE HINAAWRQKL QERFGLDSAL
ELQFERHYRR FFMPTVRGAE EGSKKRYAGL IMLPDGSEEV VYKGLETVRT DWTPLAQQFQ
QGLYLRIFRQ QPYQDYVRDY VSDTLAGRLD DQLVYRKQLR RPLAAYERNV PPHVRAARVA
DEFNRAQGRP LQYQNGGWIS YVMTIAGPEP LETLRSAIDY EHYLTRQLQP VADAILPLLR
DDFTTLMSGQ RQLF
//
