ID   A0A1X7MVG9_9LACT        Unreviewed;      1170 AA.
AC   A0A1X7MVG9;
DT   05-JUL-2017, integrated into UniProtKB/TrEMBL.
DT   05-JUL-2017, sequence version 1.
DT   27-MAR-2024, entry version 18.
DE   RecName: Full=site-specific DNA-methyltransferase (adenine-specific) {ECO:0000256|ARBA:ARBA00011900};
DE            EC=2.1.1.72 {ECO:0000256|ARBA:ARBA00011900};
GN   ORFNames=SAMN04488700_0985 {ECO:0000313|EMBL:SMH28854.1};
OS   Carnobacterium iners.
OC   Bacteria; Bacillota; Bacilli; Lactobacillales; Carnobacteriaceae;
OC   Carnobacterium.
OX   NCBI_TaxID=1073423 {ECO:0000313|EMBL:SMH28854.1, ECO:0000313|Proteomes:UP000193435};
RN   [1] {ECO:0000313|EMBL:SMH28854.1, ECO:0000313|Proteomes:UP000193435}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LMG26642 {ECO:0000313|EMBL:SMH28854.1,
RC   ECO:0000313|Proteomes:UP000193435};
RA   Afonso C.L., Miller P.J., Scott M.A., Spackman E., Goraichik I.,
RA   Dimitrov K.M., Suarez D.L., Swayne D.E.;
RL   Submitted (APR-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an
CC         N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-
CC         homocysteine; Xref=Rhea:RHEA:15197, Rhea:RHEA-COMP:12418, Rhea:RHEA-
CC         COMP:12419, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC         ChEBI:CHEBI:90615, ChEBI:CHEBI:90616; EC=2.1.1.72;
CC         Evidence={ECO:0000256|ARBA:ARBA00001279};
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DR   EMBL; FXBJ01000002; SMH28854.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1X7MVG9; -.
DR   STRING; 1073423.SAMN04488700_0985; -.
DR   Proteomes; UP000193435; Unassembled WGS sequence.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0008170; F:N-methyltransferase activity; IEA:InterPro.
DR   GO; GO:0006306; P:DNA methylation; IEA:InterPro.
DR   Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR   InterPro; IPR047939; BREX_1_PglX.
DR   InterPro; IPR003356; DNA_methylase_A-5.
DR   InterPro; IPR046816; MmeI_Mtase.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   NCBIfam; NF033452; BREX_1_MTaseX; 1.
DR   PANTHER; PTHR33841:SF1; ADENINE-SPECIFIC METHYLTRANSFERASE PGLX; 1.
DR   PANTHER; PTHR33841; DNA METHYLTRANSFERASE YEEA-RELATED; 1.
DR   Pfam; PF20473; MmeI_Mtase; 1.
DR   Pfam; PF02384; N6_Mtase; 1.
DR   PRINTS; PR00507; N12N6MTFRASE.
DR   SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
PE   4: Predicted;
KW   Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW   ECO:0000313|EMBL:SMH28854.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000193435};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:SMH28854.1}.
FT   DOMAIN          290..376
FT                   /note="MmeI-like DNA-methyltransferase"
FT                   /evidence="ECO:0000259|Pfam:PF20473"
FT   DOMAIN          474..602
FT                   /note="DNA methylase adenine-specific"
FT                   /evidence="ECO:0000259|Pfam:PF02384"
SQ   SEQUENCE   1170 AA;  137317 MW;  D0D02834374CDA30 CRC64;
     MKTFAREARK KLIISVKQRA AYFKITSSGI DELQVLEGIK LVNGQPVNKK TSDYYTDLVN
     KIKLLERETN YKQAYEEVME EVAYTWFNRL ITFRFMEVHD YLPIRMLLLS SLVNGKEEPD
     ALTDIGLLID ELNLEEKLIW SLQDDHNQNE LFKYLLIQQS HQLGNLIPTA FEPIGGSEEL
     LLPDNLLSTG SVVQDLVRAV EISNWQEVEV IGWLYQYYQS EIKEQVGGLK NYTVSKYNLA
     TVTQLFTPKW IVRYMLQNSL GKLYNERYPS NELTDRFDYF LKYNKEEPLL PTTFQNLEDI
     RLVDPACGSG NILIEAFDLL YDMYLEQGYS PKEVPQYIIG KNLYGFEIDK RSTQISHISL
     FLKAVEKNPR IIRHQQKFDF HIYEYIDAVV EVSEEMLEIV FEEEEIERYR TAESKQENGK
     QFGTLITFPE SYDDLLIKLN NFLEEKTEDL YIQAVKSELR KKVLPILNIS HFLTIKYDVV
     CTNPPYHNKF NPILKKFMQQ NYPSTKSDMY SAFIEKTFSM TKKNGYAALM TPYTWMFISS
     HEKLRKYIIE NGAISSLVQL EYSAFEDATV PLCTLVLQNQ HEHTVGAYVR LTEFKGGMNI
     QDKKIKEAST NKNCFYLFEV NQMNYKKIPG NPISYWIPIE KVSRIYNNNE TLEKFVEIKK
     GLATGKVSLF IKYWHEISLN NFSIMIKNAK WYPCHKGGDY NKWYGNFEKI INWENNGEEI
     KNYRDNNGKL LSRPQNLDYM QKRGIVFSKI TSGGVSCRIM TGEEFFDDAV QGMFLKDEKL
     YNYILALLNS KLSGYFLSFL NPTLNKQIYD LKRIPVIISE NLEINKYTVK AVLLSKKDWD
     SFETSWDFEQ HPFITYQEDF RIINDIFQKW SNVAKQRFDQ LKENEEELNR LFIDIYGLQD
     ELTPKIEDED VTVRKTDLSR DVKSFLSYLV GVIFGRYSLD KPGLIYGGGD FELEQYQTYK
     PDKDNVIPIT DEHYFEDDIV SRIIELVTII FGEQTVEENL QFIAEALGMK TNENSREALR
     RYFMKDFFKD HKKIYQKRPI YWQMTSGKED AFKGLIYLHR YETNTLARVR TDYVLPLTNT
     ISELMRQAQL VSDGSDSSKE VAKAQKTKEK FQKQLQELRD YDLILKNLAD QEIELDLDDG
     VKVNYEKFQN IPVTGTENHR VTQMNLLEKI
//