ID   A0A1X7PF39_9MICO        Unreviewed;       689 AA.
AC   A0A1X7PF39;
DT   05-JUL-2017, integrated into UniProtKB/TrEMBL.
DT   05-JUL-2017, sequence version 1.
DT   27-MAR-2024, entry version 17.
DE   SubName: Full=Putative drug exporter of the RND superfamily {ECO:0000313|EMBL:SMH50026.1};
GN   ORFNames=SAMN06295885_3477 {ECO:0000313|EMBL:SMH50026.1};
OS   Rathayibacter oskolensis.
OC   Bacteria; Actinomycetota; Actinomycetes; Micrococcales; Microbacteriaceae;
OC   Rathayibacter.
OX   NCBI_TaxID=1891671 {ECO:0000313|EMBL:SMH50026.1, ECO:0000313|Proteomes:UP000193711};
RN   [1] {ECO:0000313|Proteomes:UP000193711}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=VKM Ac-2121 {ECO:0000313|Proteomes:UP000193711};
RA   Varghese N., Submissions S.;
RL   Submitted (APR-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the resistance-nodulation-cell division (RND)
CC       (TC 2.A.6) family. MmpL subfamily. {ECO:0000256|ARBA:ARBA00010157}.
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DR   EMBL; FXBM01000003; SMH50026.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1X7PF39; -.
DR   STRING; 1891671.SAMN06295885_3477; -.
DR   OrthoDB; 2365435at2; -.
DR   Proteomes; UP000193711; Unassembled WGS sequence.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR   InterPro; IPR004869; MMPL_dom.
DR   InterPro; IPR000731; SSD.
DR   PANTHER; PTHR33406; MEMBRANE PROTEIN MJ1562-RELATED; 1.
DR   PANTHER; PTHR33406:SF6; MEMBRANE PROTEIN SCO0839-RELATED; 1.
DR   Pfam; PF03176; MMPL; 2.
DR   SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR   PROSITE; PS50156; SSD; 2.
PE   3: Inferred from homology;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        12..32
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        172..190
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        197..218
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        230..252
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        273..294
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        300..333
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        367..389
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        513..530
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        537..558
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        570..589
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        610..637
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        643..676
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          216..327
FT                   /note="SSD"
FT                   /evidence="ECO:0000259|PROSITE:PS50156"
FT   DOMAIN          538..668
FT                   /note="SSD"
FT                   /evidence="ECO:0000259|PROSITE:PS50156"
SQ   SEQUENCE   689 AA;  70680 MW;  6BE25E95720C679A CRC64;
     MSPLALLVRT RRGAWITVLA AVLSVGALFA LLPSGSEAGF PRSGLPESAP SAEVAALLEE
     FPSADATAGV VLWNRDSGLT AADTAAIDER ARELAALSTT PDAVRPQFSD DGRAALVAVP
     LSASDVEADV ESIADELRAT GSADLPTGLD SYLTGAVGFQ ADVSNAFAGA DFRLLLVTVI
     VVAVLLIATY RSPILWIVPL AVVGVADGLA RIVVGALAEA VGLSIDASVS GILSVLVFGA
     GTNYALLLVA RYREELLHEE DRHRAMTTAV RSAGPAIAAS GGTVALSLLT LLLAELAGNR
     ALGFACAVGV VIAIVFALVV LPSALVLCGR GLFWPFVPRP RGADAVPRKD GLWTRLGRGV
     ARRPGRVAIV ATVGVALLSL GLVGASVGLS QTEQLLGDPE SVRAQVVIDE SFGAGLTAQT
     TVLTPDDAVA DAVVLAEGTS GVETVRPGES ANGLTSLSLV LASEPESAES FATITALRAA
     YAEATGPVAQ SLVGGSDATA LDTRSASERD QGLIIPIILA IVFVILALLL RSLVAPVLLI
     ASVLATFFAS LGAANLIFRG LLGFPAFDAN VVLFAFLFLV ALGVDYNIFL VTRAREERAL
     HGTREGMVRA LASTGGVITS AGVLLAAVFA VLGVLPVVAL TQIGVIVCIG VLLDTLVVRT
     VLVPALVFLT GDVFWWPSSR RTARHTASA
//