ID A0A1X7RB81_9SACH Unreviewed; 619 AA.
AC A0A1X7RB81;
DT 05-JUL-2017, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2017, sequence version 1.
DT 24-JAN-2024, entry version 17.
DE SubName: Full=Similar to Saccharomyces cerevisiae YGR191W HIP1 High-affinity histidine permease, also involved in the transport of manganese ions {ECO:0000313|EMBL:SMN22928.1};
GN ORFNames=KASA_0D00924G {ECO:0000313|EMBL:SMN22928.1};
OS Kazachstania saulgeensis.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Kazachstania.
OX NCBI_TaxID=1789683 {ECO:0000313|EMBL:SMN22928.1, ECO:0000313|Proteomes:UP000196158};
RN [1] {ECO:0000313|EMBL:SMN22928.1, ECO:0000313|Proteomes:UP000196158}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Afonso C.L., Miller P.J., Scott M.A., Spackman E., Goraichik I.,
RA Dimitrov K.M., Suarez D.L., Swayne D.E.;
RL Submitted (APR-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the amino acid-polyamine-organocation (APC)
CC superfamily. YAT (TC 2.A.3.10) family. {ECO:0000256|ARBA:ARBA00006983}.
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DR EMBL; FXLY01000015; SMN22928.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1X7RB81; -.
DR STRING; 1789683.A0A1X7RB81; -.
DR OrthoDB; 1438808at2759; -.
DR Proteomes; UP000196158; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:UniProt.
DR GO; GO:0006865; P:amino acid transport; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1740.10; Amino acid/polyamine transporter I; 1.
DR InterPro; IPR004841; AA-permease/SLC12A_dom.
DR InterPro; IPR004762; Amino_acid_permease_fungi.
DR InterPro; IPR004840; Amoino_acid_permease_CS.
DR NCBIfam; TIGR00913; 2A0310; 1.
DR PANTHER; PTHR43341; AMINO ACID PERMEASE; 1.
DR PANTHER; PTHR43341:SF13; HISTIDINE PERMEASE; 1.
DR Pfam; PF00324; AA_permease; 1.
DR PIRSF; PIRSF006060; AA_transporter; 1.
DR PROSITE; PS00218; AMINO_ACID_PERMEASE_1; 1.
PE 3: Inferred from homology;
KW Amino-acid transport {ECO:0000256|ARBA:ARBA00022970};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000196158};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 111..130
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 142..175
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 219..238
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 250..272
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 339..359
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 396..418
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 439..458
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 464..485
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 506..531
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 551..568
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 110..575
FT /note="Amino acid permease/ SLC12A"
FT /evidence="ECO:0000259|Pfam:PF00324"
FT REGION 14..52
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 22..52
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 619 AA; 67381 MW; DE6D7985B8B084BD CRC64;
MKNPLSKEYW TEVVDGFRPA ETGNGTRNNN DSSSEMELTT EPTTSDIPVG EGSAFSQTEK
KLSATTTSHL LQGDSKDGLR LTQTTNDITS TTSQEKLQDV AMNKDLDVRH LITLAVGGAI
GTGLFVNSGA SLTTGGPASL VIGWIIVSTC LFTVINALGE LAAAFPIVGG FNVYITRFVD
PALGFSININ YLAQWLVLLP LELVAASITI RYWNEEINSD AWVAIFYTVI GLANMLDVKS
FGETEFVLSM VKILAIIGFT ILGIVLTCGG GPKGGFLGGK YWHNPGAFVG STSGSKFKGL
CSVFVTAAFS YSGIEMTAVS AAESKNPRET IPKAAKRTFW LITASYVTIL TLVGCLVPYN
DPRLLKGTSS VDAASSPLVI AIENGGIKGL PSLMNAIILI AIISVANSSV YACSRCMVAM
SHIGNIPKMF SRVDRKGRPL NAILATLFFG LLSFIAASDK QEEVFTWLSA LSGLSTIFCW
MAINLSHIRF RQAMVAQNIS LDELPFISQT GVWGSWYGFI VLFLVLIASF WTSLFPVGGS
GADAESFFEG YLSFPILLAC YFGHKLWFKR KQLMVNLDEM DLVSNRRPVD LELRRREMAL
EKEALAKRSI WFKFVHIWC
//
