ID   A0A1X7RY99_ZYMTR        Unreviewed;      1934 AA.
AC   A0A1X7RY99;
DT   05-JUL-2017, integrated into UniProtKB/TrEMBL.
DT   05-JUL-2017, sequence version 1.
DT   27-MAR-2024, entry version 21.
DE   RecName: Full=1-phosphatidylinositol 4-kinase {ECO:0000256|ARBA:ARBA00012169};
DE            EC=2.7.1.67 {ECO:0000256|ARBA:ARBA00012169};
GN   ORFNames=ZT3D7_G7324 {ECO:0000313|EMBL:SMQ52171.1};
OS   Zymoseptoria tritici ST99CH_3D7.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Dothideomycetes;
OC   Dothideomycetidae; Mycosphaerellales; Mycosphaerellaceae; Zymoseptoria.
OX   NCBI_TaxID=1276538 {ECO:0000313|EMBL:SMQ52171.1, ECO:0000313|Proteomes:UP000215127};
RN   [1] {ECO:0000313|EMBL:SMQ52171.1, ECO:0000313|Proteomes:UP000215127}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Kjaerup R.B., Dalgaard T.S., Juul-Madsen H.R.;
RL   Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the PI3/PI4-kinase family. Type III PI4K
CC       subfamily. {ECO:0000256|ARBA:ARBA00006209}.
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DR   EMBL; LT853698; SMQ52171.1; -; Genomic_DNA.
DR   STRING; 1276538.A0A1X7RY99; -.
DR   Proteomes; UP000215127; Chromosome 7.
DR   GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR   GO; GO:0046854; P:phosphatidylinositol phosphate biosynthetic process; IEA:InterPro.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   CDD; cd05167; PI4Kc_III_alpha; 1.
DR   Gene3D; 1.10.1070.11; Phosphatidylinositol 3-/4-kinase, catalytic domain; 1.
DR   Gene3D; 1.25.40.70; Phosphatidylinositol 3-kinase, accessory domain (PIK); 1.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR   InterPro; IPR036940; PI3/4_kinase_cat_sf.
DR   InterPro; IPR018936; PI3/4_kinase_CS.
DR   InterPro; IPR001263; PI3K_accessory_dom.
DR   InterPro; IPR042236; PI3K_accessory_sf.
DR   InterPro; IPR045495; PI4K_N.
DR   InterPro; IPR015433; PI_Kinase.
DR   PANTHER; PTHR10048:SF15; PHOSPHATIDYLINOSITOL 4-KINASE ALPHA; 1.
DR   PANTHER; PTHR10048; PHOSPHATIDYLINOSITOL KINASE; 1.
DR   Pfam; PF00454; PI3_PI4_kinase; 1.
DR   Pfam; PF00613; PI3Ka; 1.
DR   Pfam; PF19274; PI4K_N; 1.
DR   SMART; SM00145; PI3Ka; 1.
DR   SMART; SM00146; PI3Kc; 1.
DR   SUPFAM; SSF48371; ARM repeat; 1.
DR   SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR   PROSITE; PS00915; PI3_4_KINASE_1; 1.
DR   PROSITE; PS00916; PI3_4_KINASE_2; 1.
DR   PROSITE; PS50290; PI3_4_KINASE_3; 1.
DR   PROSITE; PS51545; PIK_HELICAL; 1.
PE   3: Inferred from homology;
KW   Kinase {ECO:0000256|ARBA:ARBA00022777};
KW   Reference proteome {ECO:0000313|Proteomes:UP000215127};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   DOMAIN          1367..1554
FT                   /note="PIK helical"
FT                   /evidence="ECO:0000259|PROSITE:PS51545"
FT   DOMAIN          1655..1918
FT                   /note="PI3K/PI4K catalytic"
FT                   /evidence="ECO:0000259|PROSITE:PS50290"
SQ   SEQUENCE   1934 AA;  214940 MW;  026507855A5E052A CRC64;
     MKLTTRATRR NALEKLAALA AQSTSTEDDD RDIKRLFDLS KSHAESRTDG TVNGESTVKT
     SSIPMSVRES EVLTALCKAA PVVQTTKDAE SLLQQLVPYV SEAHQQVFAV TPLHQPLPPW
     ETLSYDLTTA VLALGLNHPS LREESWTCIR RTVDELASSA DNTEWPKSSE EGTVELELNK
     QTFRVIQLHV SLVGFFHAVA KYVRVWSPEQ RTTLVPQLRR VLSEKFMVSL EGGLSAIRNT
     SNSSRLVKDW KRWIRHYTAK GKPLGAMLLQ QAFMNVVEES VLALIPLPEP VPGTALLDVL
     LTQSTISKGQ AQSDGFVGSL SDVISDEMRL LEADADYLKL GSEWQQRLAR EVKCSVLRSF
     LCCCILEGET PHTDVLLAWL ESITVDPMQM VDDELAKTVL KGMAILAGIS STVAFALARS
     LPRLIVRGKM SPTTATVACE CLARVLKLVP QELAISTVYS LGNILSSGSQ NGETYRSALF
     DSTLSIGNES QGLQFSTQQN IGSSISLVIS DEEEASAVYS TVVQAVVAVA VARSEVQLTA
     LVISMLVQKI GRINEAVDAR IIVETSALGL CGGPNELKGL LRFYARVGSE ALVQNSTSIS
     AAVTEGRLRL STWIKKDSPF FEPYLAHLLG MCVSSGDTAG ERTIDVALAS KTIAQLFRPM
     AILASHDISR KPQLEDEDEI LALGRDAWFN IAVHGFTLNA PSTKEHLEDL QTLALYSLPL
     VDEARVDMPD SSIDLNPVLR RGAHSHQHDH QKQSLIRALP SCEHDIKSLS YSESVFLNAA
     LLVSTLRAQG GDCTAVLPYF LENKVKTTAL GKCMLAVASH SVDVYLRVAL SGQRQEFAAP
     QIATQLAAFF EGCCHRISKV QQAAIASCNR IISVVPSALC QKASLFALLE LLSLMWKSCL
     DTETDEYGWR SQYSSVKGNV SIQLSDDVQH RQSTLASLHQ NARVWVHKAI DVAPLDVKGH
     LQAYLEDYED DGSYGHIALG RSFAVEMGSV VPSTDQRLTS LDAQRNLNVT TASDFVAQYT
     TRQEYRHLDA RLETDEEWAL IDYSGKALPA LMSDDDPVHR EAAELKTLSR QLRGRVPIPF
     TKVRETLRDA AGMLSRSASN HVVLIQDLVG IPFIIFTKQS INLGISLWLG IIKENPSLES
     RVLVEVAAGW EASVRSKRGF FSTSLQHLDP FYVKEEFAPS NWDAIKRREQ ATHNLISPHL
     RLTHFLSSHF SASRLTSPSV ERIYNRLMRI TLLSMKHAVS QPLAREVHFH IVLLALKVLK
     YSTHISSASQ WRLKDAILSG GLSWFATAPK YSYGSNRLQM RAEKKLLMDV SATIDDLGGV
     GEKATKALPS LRQKAALLSQ LLTHEIGRLT VWIAPLAQEP KSIAPGHNEL NSQETTISAL
     LQTAWDEDPR IAVQLTKRYS TTNKLAQDVR RFLIKEPQKA IHEPDALYIL LGPSLPSDLQ
     PQLKYLLYWA PINPMAAVTY FLPAYGNHPF VIQYAVRAVE SHHVDVNFFY VPQIVQTLRY
     DALGYVERYI IETATFSQLF AHQIIWNIKA NAYKDEESQI PDPAKPVLDR VMNSLIDSFS
     SEDKDFYERE FDFFGKVTGI SGTLKPFIKR PKPEKKQKIE EELRKIQVDV GVYLPSNPDG
     VVIGIDRKSG KPLQSHAKAP YMATFRIRKE EGEADTNPTP SSQNGIVAKR RTYEVWQSAI
     FKVGDDCRQD VLALQLIAAF RGIFNNVGLD VYVFPYRVTA TAPGCGVIDV LPNSISRDML
     GREAVNGLYE YFVSKYGYED SIRFQEARGN FIKSMAAYSI ISYLLQFKDR HNGNIMVDDA
     GHILHIDFGF CFDIAPGGVK FERAPFKLTP EMVAVMGGSS SAPAFKVFEE LCIKAFLAAR
     QHVEQLSHIV STMLDSGLPC FKPATIQHFR ERFVLEKSDR EAAEFVRKLV HWSERSYSTA
     VYDYFQLLTN GIPY
//