ID A0A1X7S0E7_ZYMTR Unreviewed; 3886 AA.
AC A0A1X7S0E7;
DT 05-JUL-2017, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2017, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=Non-specific serine/threonine protein kinase {ECO:0008006|Google:ProtNLM};
GN ORFNames=ZT3D7_G8306 {ECO:0000313|EMBL:SMQ53153.1};
OS Zymoseptoria tritici ST99CH_3D7.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Dothideomycetes;
OC Dothideomycetidae; Mycosphaerellales; Mycosphaerellaceae; Zymoseptoria.
OX NCBI_TaxID=1276538 {ECO:0000313|EMBL:SMQ53153.1, ECO:0000313|Proteomes:UP000215127};
RN [1] {ECO:0000313|EMBL:SMQ53153.1, ECO:0000313|Proteomes:UP000215127}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Kjaerup R.B., Dalgaard T.S., Juul-Madsen H.R.;
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Serine/threonine protein kinase which activates checkpoint
CC signaling upon genotoxic stresses such as ionizing radiation (IR),
CC ultraviolet light (UV), or DNA replication stalling, thereby acting as
CC a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-
CC Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of
CC DNA damage, involved in the regulation of DNA damage response
CC mechanism. Required for the control of telomere length and genome
CC stability. {ECO:0000256|ARBA:ARBA00025079}.
CC -!- SUBUNIT: Associates with DNA double-strand breaks.
CC {ECO:0000256|ARBA:ARBA00011370}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; LT853699; SMQ53153.1; -; Genomic_DNA.
DR STRING; 1276538.A0A1X7S0E7; -.
DR Proteomes; UP000215127; Chromosome 8.
DR GO; GO:0006325; P:chromatin organization; IEA:UniProtKB-KW.
DR CDD; cd05163; PIKK_TRRAP; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR003152; FATC_dom.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR InterPro; IPR003151; PIK-rel_kinase_FAT.
DR InterPro; IPR014009; PIK_FAT.
DR InterPro; IPR046807; Tra1_central.
DR InterPro; IPR046805; Tra1_ring.
DR PANTHER; PTHR11139; ATAXIA TELANGIECTASIA MUTATED ATM -RELATED; 1.
DR PANTHER; PTHR11139:SF1; TRANSFORMATION_TRANSCRIPTION DOMAIN-ASSOCIATED PROTEIN; 1.
DR Pfam; PF02259; FAT; 1.
DR Pfam; PF02260; FATC; 1.
DR Pfam; PF00454; PI3_PI4_kinase; 1.
DR Pfam; PF20175; Tra1_central; 2.
DR Pfam; PF20206; Tra1_ring; 1.
DR SMART; SM01343; FATC; 1.
DR SMART; SM00146; PI3Kc; 1.
DR SUPFAM; SSF48371; ARM repeat; 4.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS51189; FAT; 1.
DR PROSITE; PS51190; FATC; 1.
DR PROSITE; PS50290; PI3_4_KINASE_3; 1.
PE 4: Predicted;
KW Chromatin regulator {ECO:0000256|ARBA:ARBA00022853};
KW Reference proteome {ECO:0000313|Proteomes:UP000215127}.
FT DOMAIN 2689..3246
FT /note="FAT"
FT /evidence="ECO:0000259|PROSITE:PS51189"
FT DOMAIN 3504..3838
FT /note="PI3K/PI4K catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50290"
FT DOMAIN 3854..3886
FT /note="FATC"
FT /evidence="ECO:0000259|PROSITE:PS51190"
FT REGION 166..202
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 852..875
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3257..3332
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3282..3312
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3314..3332
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3886 AA; 439815 MW; D64656C0E4D73FFF CRC64;
MADRQMETIE GKLQDASLDI KTKANVLTEL RDSLDLYCSS PNYGTFLAKF VPIFLNILSG
SPVFTSTSPE QKIRQCALEI FHRLPVAADV GAMEPYAAKI VDKCLELVKV ENEENSVLCL
KIVMDFCRYH TKTSGVAERA QPFLELIMEI FDSMDQTVKD TFESQTPIPA TAAPGTPSNT
GTPGSPVASS SQSLLPDPAA ETQTTRQLIK GMHSFKVVAE CPIIVVSIFQ AHKHLAPKNV
GQFTPRIKNA ILLQAGPQKK AHEEAEQNGT VFTGLAKEIR AKGQASAFGD LVTAQVKTMS
FLAYILRAYR ESLSDFLPIL PHLTVRLLRD VPRSHTATRK ELLVAIRHII NFNFRDVFLP
VILPLLDSRT LVGDSLTADI TLRPLAYTML ADLIHHVRER LNAEQISKVV QVYVGHLTGD
DGVEVPGTSY QTMSAKLLLN MAECMSKVEE KKDARFLMMS VLNGIADKFA AMNRAYPNAV
KLYRQQQEVA SSADGTPLSD NYLADKDNKP DWDETDIFSA TPIKAVNPRD RATDPVTENK
FLFKNLLQGL KQFFYQLRNS NPPRIKDEVD TANAPPHWGE LSSGFEAEEV EVLLKLFREG
ATCFQYYAPL DQGADATPEA TSSLSATANS KEEKDLLETF ATIFHHLDPA VFYEIFTSGT
PSGINFLYEQ SFKHSALLHI PQFLLASEAT SSAFCGMLLK FLMGKLDEVG ESDGVKTSVL
LRLFKLSFMA VTLFSQHNEN VLLPHVRELI TRSIELSVTA AEPTNYFLLL RSLFRSIGGG
RFEHLYKEIL PLLEMLLEVL NTQLAAAPDG STRDLFVELS LTVPARLSHL LPHLSYLMRP
LTVALRSGDQ SYVPSQRSYS NDRSSTDVRS AGSSSELTAQ GLRTLELCVD NLTADYLDPI
MQPWMEDIMG SLWRMLKPAS ITGASMNGAN GQTVSTGHQG AHTAVRILGK LGGRNRRFLT
NPPDLEFREY ADDEASFDVR FIGAVSNGGE RPLPARLGID TAIDKLWEVP KTAPAKKADE
FHKRQAFKFI TSHVKLLVGS DNLPDDMARL VRLQADDLAT KNFDFGSDLF SISERSKSTV
KKDAQQHTLL KLLKAIIYAT SIESLKDEAG KFLQGIYRHF MIVELGVAVA KEKHKRRPFD
VRSGEGPVYV ETSVLADAIC QSLASEQKTI REVAENAMLS CLKIASTIFG DAQKAECLPF
FSRLAEAFCH ACYEEEWFTK SSGSLGIGIL TDTDKMGFSD AWLTERMAEM LKALLFVIKD
MPQELPANIR VQAKDTIITV AKRFATSGIE KKEDLENKES KLRVLTQTLV SETSHMNRHV
REASQQTLRT LAAHLDMQLH ELILPVKTVL TEHIFIKPLR ALPFTAQIGY IDAINFLLDM
PNEKEILPFE DNLNRLLFET LALVDADDES LAPKPYEYRT AESIVRLRVA GLKLLTTAIR
LPGFSPTAAP APGQTGQPPN NQHRARVISI FFKSLYSKNK EVAGAANAGL KIVLQSTSKL
PKDLLQNGLR PILMNVQDPR KLSVEGLEGL RTLLQLLHNY FKVEIGTRLL DHMKAIADPP
TLQKVSFTLI DAQPKMKVVT AIFNVFHLLP SQAAQFLQDL VDRVLSLEEA LRRTRSSPFR
EPLIKYLNHY PNESWTYFSE KMKDERRGKF FAQMLADKES GALREKVLKE IDGLIETFAG
EGSEEDKAQA AVNSIHAAYA ICQFPDTAKQ LLENEKARKA LVDAAKSVLT QLQRGTLPKN
LRLAATQCAE QIMDVLITYM KLQPKDLDTL FDIFDSCIKG ELQQCPSLIA FLYKHIIVNE
DVDYQRSILT RCLDIYAAKD TPQKLKWFVF RMLSNPILAN DVMRNWDLLF QPNQKGTALM
DKAFTDQFHS KLWRPQSVSD ISDDNTYGVD HSRMELLQTS AFLIKYHHSM VQDARKDLIK
FGWNYIRLDD HINRFAAYCL ISYFIHHYET PPKIAMQVYN ALLRAHQAEG RNIVMQSLEV
LEPVLKKRLG GPEGRQSVWA RLPRKILSEE ISNVQQLTSV YNFIVRHPDL FYDARDSFAQ
IIIASMNKVA SLPSSSVETR KLALNLFTLM FKWEERTVRE HGSLAGAESP TGEANTNPKK
AAVAPAHARL TFVKYMVQFI ATVPERFPCG PPKIKEGNAA NAKETPPPET VTKTMDLLLK
LLSAPYWDDV DIDAMFPKVT EQILCGDHKA EEKLEVWITR QVNTIQIVKV MLNSRSDEWV
VARLPQLQKM LAKPLKSEHL EIQEALHNAD IAENVVPNLP PVLQRALEPI PIPQPDEELP
DADSPTDEFV TFLTTTAGDA LNGTGHVAGI NILWIMSKRK PEDIDPHITA LLKTLQTKLA
KDHLAALMAP QAALAQGMQP PANNPQEAEV TINMIIKVIE MLSTRISTLG EQRRPYLSVL
ASLVERSTNN PLCEKILSQV DSWVFHPTEP VPTLKEKTAV LQKMLLFENR ADPTLYGKFM
NLVIRIYEDP KITRSELAVR MEHAFLIGLR SSDIDMRSRF MTIYDKALSR STSNRFFKLI
SEQQWDVLAE TFWLSQVIQL MFGSLDQNSV VHLHQEDFRC LPASKVFSTY TSDARLGDVL
VDDSLEELLV QEKSFMNELS TVRAREILVP LADIQHTDWQ LAHDIWVAYF PMVWSTLNKE
DREDIEAGLV ALLTKDFHQR QVDRRPNCVS TLLEGIAKAR PRVKFPSHVM KYLAKSYDAW
YIAATFMEDL AMKPIVDTAN VRESNLDALV ETYAGLEESD LFYGTWRRRA AYVETNAALS
YEQNGIWDKA QNMYEQAQVK ARTGSLPYSQ GEYMLWEDQW VLCGQKLQQW DVLGEFAKHE
NINDLYLEAM WRNYETWQTT ENREHLETVI KAVSDAPTPR RMFFQAFISL LKLHNKTENP
QEFARICDEN IQLSIRNWHK LPRRITNAHI GLLQNFQQLV ELHDASVICQ SLAQTNAGNL
DTKSQELKVL LSTWRDRLPN LWDDINAWQD LVTWRQHIFQ LINGTYLSLL PNNGANATGN
SYAYRGYHET AWIINRFAHV ARKHQMPEVC ITQLSKIYTL PNIEIQEAFL KLREQAKCHY
QNPSELTNGL DVINNTNLNY FGPQQKAEFY TLKGMFLSKL NQKEEASDAF GSALFFDIKL
PKAWAEWGRY SDKLFKEEPT NLELGSNALS CYLEAAGQYK SAKSRKLLSR ILWLLSLDDA
EGQLSQKFYD YHGDHPWWYW VTFIPQLLNN LSRSESEANI AHQILTNLAK TYPQALHFQL
RTSHEDMQVI RKSQLLREQK EKAQKAKQQA GEAVKTESPA RPESGDGSQS RPATATSGGE
AVQASGNATA GEDTKMEGTE EAKKEEAPKP KKPWEHTELL VITLRTAFPL LYASMEAMVE
QIQRHFKCPP DEDAYRLIVA LLNDALSYVG RSPSSFTAEN KLPPQTEANI TRFAESILPP
HIRKAFEMDF VTKKPTMLEY IVKLRRWRDK LAERLDRRSS TFHLAESTHL SGFRFVWFDE
VEIPGQYLQH KDKNQDFVRI ERFLPVVDLV RGVAGCHRRL KIRGHDGSVH PFAIQHPAPR
HSRREERILQ LFRIFNSTLS KKKESRRRNL QFHLPVMVPL SPSIRMIQDD ASYVTLQAVY
EDYCRRNELD KDEPIMFTME KMRNSSPMKQ DQWLNMRIES LNYVQDRYVP KDLVRNYFAA
TYPSYDSFWL FRRQFSYQLA ALTYITFTMY MTVRYPNKMH IAKGNGNIWG SELLPFMLAN
RPSFHQPEPV PFRLTPNLQV LMGPIHTEGI FTCALMAIAR CLTSDSTVST TPPAAAAGVN
AAAPSTAVAA PHDSAHSNSE LEHHLSIFIR DEIQFWYTNS HRGQKEIDMR DHVQRNADAI
VNKAVVLAKE PTGNNLPACQ SALDLIAKAT NPEKLSQTDL IWMPWL
//
