ID A0A1X7SNK1_AMPQE Unreviewed; 592 AA.
AC A0A1X7SNK1;
DT 05-JUL-2017, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2017, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=EGF-like domain-containing protein {ECO:0000259|PROSITE:PS50026};
OS Amphimedon queenslandica (Sponge).
OC Eukaryota; Metazoa; Porifera; Demospongiae; Heteroscleromorpha;
OC Haplosclerida; Niphatidae; Amphimedon.
OX NCBI_TaxID=400682 {ECO:0000313|EnsemblMetazoa:Aqu2.1.03672_001, ECO:0000313|Proteomes:UP000007879};
RN [1] {ECO:0000313|Proteomes:UP000007879}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20686567; DOI=10.1038/nature09201;
RA Srivastava M., Simakov O., Chapman J., Fahey B., Gauthier M.E., Mitros T.,
RA Richards G.S., Conaco C., Dacre M., Hellsten U., Larroux C., Putnam N.H.,
RA Stanke M., Adamska M., Darling A., Degnan S.M., Oakley T.H.,
RA Plachetzki D.C., Zhai Y., Adamski M., Calcino A., Cummins S.F.,
RA Goodstein D.M., Harris C., Jackson D.J., Leys S.P., Shu S., Woodcroft B.J.,
RA Vervoort M., Kosik K.S., Manning G., Degnan B.M., Rokhsar D.S.;
RT "The Amphimedon queenslandica genome and the evolution of animal
RT complexity.";
RL Nature 466:720-726(2010).
RN [2] {ECO:0000313|Proteomes:UP000007879}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Lucas S., Shapiro H., Lindquist E., Tice H., Dalin E., Glavina del Rio T.,
RA Bruce D., Barry K., Pitluck S., Srivastava M., Simakov O., Chapman J.,
RA Mitros T., Hellsten U., Putnam N.H., Fahey B., Gauthier M., Larroux C.,
RA Richards G.S., Stanke M., Adamska M., Darling A., Dacre M., Degnan S.M.,
RA Zhai Y., Adamski M., Calcino A., Cummins S.F., Goodstein D.M., Harris C.,
RA Shu S., Woodcroft B., Leys S.P., Manning G., Degnan B.M., Rokhsar D.S.;
RT "The genome of the haplosclerid demosponge Amphimedon queenslandica and the
RT evolution of animal complexity.";
RL Submitted (MAY-2010) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EnsemblMetazoa:Aqu2.1.03672_001}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (MAY-2017) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; A0A1X7SNK1; -.
DR STRING; 400682.A0A1X7SNK1; -.
DR EnsemblMetazoa; Aqu2.1.03672_001; Aqu2.1.03672_001; Aqu2.1.03672.
DR eggNOG; KOG1217; Eukaryota.
DR InParanoid; A0A1X7SNK1; -.
DR OMA; YENTCIY; -.
DR Proteomes; UP000007879; Unassembled WGS sequence.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR CDD; cd00054; EGF_CA; 5.
DR Gene3D; 2.10.25.10; Laminin; 15.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR013032; EGF-like_CS.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR PANTHER; PTHR24044:SF420; NEUROGENIC LOCUS PROTEIN DELTA; 1.
DR PANTHER; PTHR24044; NOTCH LIGAND FAMILY MEMBER; 1.
DR Pfam; PF00008; EGF; 7.
DR Pfam; PF12661; hEGF; 3.
DR SMART; SM00181; EGF; 15.
DR SMART; SM00179; EGF_CA; 12.
DR SUPFAM; SSF57196; EGF/Laminin; 9.
DR SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR PROSITE; PS00022; EGF_1; 13.
DR PROSITE; PS01186; EGF_2; 13.
DR PROSITE; PS50026; EGF_3; 15.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076};
KW Reference proteome {ECO:0000313|Proteomes:UP000007879};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729}.
FT DOMAIN 1..37
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 39..77
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 79..117
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 119..157
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 167..201
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 203..241
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 243..279
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 281..319
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 321..359
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 361..398
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 400..437
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 438..473
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 475..512
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 514..551
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 553..590
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DISULFID 27..36
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 67..76
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 107..116
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 147..156
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 169..179
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 191..200
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 231..240
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 247..257
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 269..278
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 290..307
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 309..318
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 349..358
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 388..397
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 427..436
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 463..472
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 502..511
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 541..550
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 580..589
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 592 AA; 61734 MW; 2F43E935733CEAA9 CRC64;
DVCQTQTPCQ NGGTCTDYEG LDFECSCPPG FYGVNCSTDH SVCSVMMPCQ NEGTCEDGPG
FHYTCHCSPG YEGTNCTIDI SVCSTEEPCD NDGNCTDGVG LSYECDCAPG YTDINCTVDI
SVCDETSPCQ NGGTCEDGEG LDYTCDCSPG YYGQDCMNDV SVCMPCPTCS GPCLNGGSCT
DGAGLNYTCS CLPGYTDVNC TTDISYCDET SPCLNGAACV DGPGLAYNCE CIEGFNGTNC
ENDLEYCANT YCVNGTCVEG IGTNISCDCI VDYTGPRCDV QLLFCNLDIC MNGGSCREIA
GSTDTMCLCP SGFSGDMCET DDDVCDEPPT KCIHGTCSEG IGDNYTCSCD SGYSGSNCEV
DNDYCEPSSC SNGGLCVEGP GLSTSCNCTE GFTGNTCNID IDYCTNTYCQ HNGTCVEGYG
ANITCHCTNT YTGPTCAVAI CPQGYCGSNG NCVVNSNMAV CECDPGYTGD FCETDVDVCD
SSSCNGRGTC TDGPGLSYSC DCHSGFYGDD CENDTNVCEE PFACVHGTCT DGVGLNYTCV
CDPGFNGTNC SMDGLFCNET HCQNGGTCVE GHGISVSCQC PEGFTGSRCE TD
//
