ID   A0A1X7SVN2_AMPQE        Unreviewed;       842 AA.
AC   A0A1X7SVN2;
DT   05-JUL-2017, integrated into UniProtKB/TrEMBL.
DT   05-JUL-2017, sequence version 1.
DT   27-MAR-2024, entry version 18.
DE   RecName: Full=Reverse transcriptase domain-containing protein {ECO:0000259|Pfam:PF00078};
OS   Amphimedon queenslandica (Sponge).
OC   Eukaryota; Metazoa; Porifera; Demospongiae; Heteroscleromorpha;
OC   Haplosclerida; Niphatidae; Amphimedon.
OX   NCBI_TaxID=400682 {ECO:0000313|EnsemblMetazoa:Aqu2.1.06206_001, ECO:0000313|Proteomes:UP000007879};
RN   [1] {ECO:0000313|Proteomes:UP000007879}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=20686567; DOI=10.1038/nature09201;
RA   Srivastava M., Simakov O., Chapman J., Fahey B., Gauthier M.E., Mitros T.,
RA   Richards G.S., Conaco C., Dacre M., Hellsten U., Larroux C., Putnam N.H.,
RA   Stanke M., Adamska M., Darling A., Degnan S.M., Oakley T.H.,
RA   Plachetzki D.C., Zhai Y., Adamski M., Calcino A., Cummins S.F.,
RA   Goodstein D.M., Harris C., Jackson D.J., Leys S.P., Shu S., Woodcroft B.J.,
RA   Vervoort M., Kosik K.S., Manning G., Degnan B.M., Rokhsar D.S.;
RT   "The Amphimedon queenslandica genome and the evolution of animal
RT   complexity.";
RL   Nature 466:720-726(2010).
RN   [2] {ECO:0000313|Proteomes:UP000007879}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Lucas S., Shapiro H., Lindquist E., Tice H., Dalin E., Glavina del Rio T.,
RA   Bruce D., Barry K., Pitluck S., Srivastava M., Simakov O., Chapman J.,
RA   Mitros T., Hellsten U., Putnam N.H., Fahey B., Gauthier M., Larroux C.,
RA   Richards G.S., Stanke M., Adamska M., Darling A., Dacre M., Degnan S.M.,
RA   Zhai Y., Adamski M., Calcino A., Cummins S.F., Goodstein D.M., Harris C.,
RA   Shu S., Woodcroft B., Leys S.P., Manning G., Degnan B.M., Rokhsar D.S.;
RT   "The genome of the haplosclerid demosponge Amphimedon queenslandica and the
RT   evolution of animal complexity.";
RL   Submitted (MAY-2010) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|EnsemblMetazoa:Aqu2.1.06206_001}
RP   IDENTIFICATION.
RG   EnsemblMetazoa;
RL   Submitted (MAY-2017) to UniProtKB.
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DR   AlphaFoldDB; A0A1X7SVN2; -.
DR   EnsemblMetazoa; Aqu2.1.06206_001; Aqu2.1.06206_001; Aqu2.1.06206.
DR   eggNOG; KOG1075; Eukaryota.
DR   InParanoid; A0A1X7SVN2; -.
DR   OMA; YEEYCEG; -.
DR   Proteomes; UP000007879; Unassembled WGS sequence.
DR   InterPro; IPR043502; DNA/RNA_pol_sf.
DR   InterPro; IPR000477; RT_dom.
DR   Pfam; PF00078; RVT_1; 1.
DR   SUPFAM; SSF56672; DNA/RNA polymerases; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000007879}.
FT   DOMAIN          370..570
FT                   /note="Reverse transcriptase"
FT                   /evidence="ECO:0000259|Pfam:PF00078"
FT   REGION          1..63
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          215..286
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        28..63
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        220..286
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   842 AA;  89075 MW;  21614EC017B3E3F3 CRC64;
     SCRPGGSSSC HNPFGRGPPA SGPRVSSPLD SDPANSHPSS LSASGQSDTE ALPDPATSST
     SGLPSLSTIC HLQVPLLYHV PKAARNSWSG ILSAALEDVV SRPTDLDSWS RLFMLPKCVL
     FLPPFRSRRK SHDLLYLIKE RLQSWRNGEF LALWDKVTVR AAQLPRTGSS PQSDANVRRA
     RRAVEAGHLS KAIQALSSRG LAPPSHESYL ELLSKHPQSP LPASPLPLAP PDSLPPSSPP
     HTPLSPLPSS IPPSSPSVSP PLFSSPSPPP PTPPSPPPLL PTLFSPPLPS PSLTPAAVLQ
     AVRSFPLDTA PGPTGLRASH IKEAVCCPSP CRAQSTLQQL TLFVVFLSSG DCPSSVIPHL
     CGATLLASLK KSGGLRPIAV GEVLRRLTSK CLSSLVLPQV RHILPPHQVG VGCSNGAESI
     VHSLKLILAN QSIPSNSKCC LLLDFSNAFN CINRLSMFSE VRSKIPLLSN WVECCYGAQP
     NLLFGDYIIP SCCGVQQGDP LGPLLFSLVL QPIVERLESE VPGLVLNSWY LDDGVLCGSS
     DDLLAALTII EDLGPSHGLH LNLSKSLLYL PPDIASNPHP LPSAIPSTSV GFVLLGAPVG
     PPDFCRSIVQ ERVESIKASL ELLPLLEDSQ SQFSLLRSCL GLPKLLCALR TTSPDVLSSV
     TMDFDAIIFD FLSELVGGSL TSWSRCKAAL PIKLGGVGLR LASQHSSAIF LASVTACSPL
     ILSLSGQEVP PSYVSAALVA FASSAELSDL TSISELDLPI SQKSLSGLID KVNYNALLSS
     TQDIRSKALL LSSSIPHAGD WIGVLPSPNL GLHLLDCEFR LCLRYCPSCC PLPSQGDPVP
     CA
//