ID   A0A1X7SWI3_AMPQE        Unreviewed;       711 AA.
AC   A0A1X7SWI3;
DT   05-JUL-2017, integrated into UniProtKB/TrEMBL.
DT   05-JUL-2017, sequence version 1.
DT   27-MAR-2024, entry version 27.
DE   RecName: Full=Reverse transcriptase RNase H-like domain-containing protein {ECO:0008006|Google:ProtNLM};
OS   Amphimedon queenslandica (Sponge).
OC   Eukaryota; Metazoa; Porifera; Demospongiae; Heteroscleromorpha;
OC   Haplosclerida; Niphatidae; Amphimedon.
OX   NCBI_TaxID=400682 {ECO:0000313|EnsemblMetazoa:Aqu2.1.06440_001, ECO:0000313|Proteomes:UP000007879};
RN   [1] {ECO:0000313|Proteomes:UP000007879}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=20686567; DOI=10.1038/nature09201;
RA   Srivastava M., Simakov O., Chapman J., Fahey B., Gauthier M.E., Mitros T.,
RA   Richards G.S., Conaco C., Dacre M., Hellsten U., Larroux C., Putnam N.H.,
RA   Stanke M., Adamska M., Darling A., Degnan S.M., Oakley T.H.,
RA   Plachetzki D.C., Zhai Y., Adamski M., Calcino A., Cummins S.F.,
RA   Goodstein D.M., Harris C., Jackson D.J., Leys S.P., Shu S., Woodcroft B.J.,
RA   Vervoort M., Kosik K.S., Manning G., Degnan B.M., Rokhsar D.S.;
RT   "The Amphimedon queenslandica genome and the evolution of animal
RT   complexity.";
RL   Nature 466:720-726(2010).
RN   [2] {ECO:0000313|Proteomes:UP000007879}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Lucas S., Shapiro H., Lindquist E., Tice H., Dalin E., Glavina del Rio T.,
RA   Bruce D., Barry K., Pitluck S., Srivastava M., Simakov O., Chapman J.,
RA   Mitros T., Hellsten U., Putnam N.H., Fahey B., Gauthier M., Larroux C.,
RA   Richards G.S., Stanke M., Adamska M., Darling A., Dacre M., Degnan S.M.,
RA   Zhai Y., Adamski M., Calcino A., Cummins S.F., Goodstein D.M., Harris C.,
RA   Shu S., Woodcroft B., Leys S.P., Manning G., Degnan B.M., Rokhsar D.S.;
RT   "The genome of the haplosclerid demosponge Amphimedon queenslandica and the
RT   evolution of animal complexity.";
RL   Submitted (MAY-2010) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|EnsemblMetazoa:Aqu2.1.06440_001}
RP   IDENTIFICATION.
RG   EnsemblMetazoa;
RL   Submitted (MAY-2017) to UniProtKB.
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DR   AlphaFoldDB; A0A1X7SWI3; -.
DR   EnsemblMetazoa; Aqu2.1.06440_001; Aqu2.1.06440_001; Aqu2.1.06440.
DR   eggNOG; KOG0017; Eukaryota.
DR   InParanoid; A0A1X7SWI3; -.
DR   Proteomes; UP000007879; Unassembled WGS sequence.
DR   GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR   GO; GO:0009116; P:nucleoside metabolic process; IEA:InterPro.
DR   CDD; cd09274; RNase_HI_RT_Ty3; 1.
DR   Gene3D; 3.10.20.370; -; 1.
DR   Gene3D; 3.40.50.1580; Nucleoside phosphorylase domain; 1.
DR   InterPro; IPR043502; DNA/RNA_pol_sf.
DR   InterPro; IPR000845; Nucleoside_phosphorylase_d.
DR   InterPro; IPR035994; Nucleoside_phosphorylase_sf.
DR   InterPro; IPR041373; RT_RNaseH.
DR   PANTHER; PTHR34072; ENZYMATIC POLYPROTEIN-RELATED; 1.
DR   PANTHER; PTHR34072:SF48; RIBONUCLEASE H; 1.
DR   Pfam; PF01048; PNP_UDP_1; 1.
DR   Pfam; PF17917; RT_RNaseH; 1.
DR   SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR   SUPFAM; SSF53167; Purine and uridine phosphorylases; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000007879}.
FT   DOMAIN          5..109
FT                   /note="Reverse transcriptase RNase H-like"
FT                   /evidence="ECO:0000259|Pfam:PF17917"
FT   DOMAIN          360..551
FT                   /note="Nucleoside phosphorylase"
FT                   /evidence="ECO:0000259|Pfam:PF01048"
FT   REGION          256..303
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        266..303
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   711 AA;  79957 MW;  A22BD47B86C91A75 CRC64;
     MKNPNFNQTF ILQTDASGVG VGAILSQGEE NLDEGPVTYF SKKLLPREQA YSTVEKECLA
     IILAIKHFSA YLIGRSFIIQ TDHRALQWLH KFKEKNARLT RWSLILQPYN FTIQHQKGVA
     NANADALSRL ERKSTSCQRG REEICELVVS FVLIKNKVWL TDNKKPDLAA VKQIFDSSDD
     HYLTIGAGLK VKTADLIEMP GTASTKLHLV FQRWFDADRD VNWDTLIKLC DDNPDKLGKA
     KSNLLEHIGK AGLAESNGTA QANAKKQKID PKEPIDSAAT GEDKSKSEDQ KSDPPPDVSK
     YCPKLEDIER KIEMKTIEEL TEGEKEFISK VRYILVTATT IEYCAVMGSI DPPGGDGKYI
     RVITTDETGN FILGKYGSCN VAITRTGQGP DETEDILVSV QNDVKADFVI AIGICYGAKE
     SKTEELSDKT NLGDIIVAKS IIDTAHQRIE GKNTIVLATE YHCGKNLLKK FKHDEVFKIE
     GKAVKVHHQG SLASEFTLFR SKEAKEEKLK YIQKALGGEM EAKGIHKAAE SVGFEWIVIK
     AIVDWGTEEK DKKWQPFGAV SCARFVLQRL KDQQGNQDQT QHDDQNDYIR LHDEEGTRDS
     LKQLNDNFSL VMMDVEEAFD NEIQDNPKLL KKITTWLRYR EDLKYHADTI ATLNNVSTIG
     DVLTAIRPLF DCTDCALLVN MCQQFIPNAK EEVSKLESHH ERAKEFCQST T
//