ID   A0A1X7T481_AMPQE        Unreviewed;      1028 AA.
AC   A0A1X7T481;
DT   05-JUL-2017, integrated into UniProtKB/TrEMBL.
DT   05-JUL-2017, sequence version 1.
DT   27-MAR-2024, entry version 21.
DE   RecName: Full=Death domain-containing protein {ECO:0000259|PROSITE:PS50017};
OS   Amphimedon queenslandica (Sponge).
OC   Eukaryota; Metazoa; Porifera; Demospongiae; Heteroscleromorpha;
OC   Haplosclerida; Niphatidae; Amphimedon.
OX   NCBI_TaxID=400682 {ECO:0000313|EnsemblMetazoa:Aqu2.1.09297_001, ECO:0000313|Proteomes:UP000007879};
RN   [1] {ECO:0000313|Proteomes:UP000007879}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=20686567; DOI=10.1038/nature09201;
RA   Srivastava M., Simakov O., Chapman J., Fahey B., Gauthier M.E., Mitros T.,
RA   Richards G.S., Conaco C., Dacre M., Hellsten U., Larroux C., Putnam N.H.,
RA   Stanke M., Adamska M., Darling A., Degnan S.M., Oakley T.H.,
RA   Plachetzki D.C., Zhai Y., Adamski M., Calcino A., Cummins S.F.,
RA   Goodstein D.M., Harris C., Jackson D.J., Leys S.P., Shu S., Woodcroft B.J.,
RA   Vervoort M., Kosik K.S., Manning G., Degnan B.M., Rokhsar D.S.;
RT   "The Amphimedon queenslandica genome and the evolution of animal
RT   complexity.";
RL   Nature 466:720-726(2010).
RN   [2] {ECO:0000313|Proteomes:UP000007879}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Lucas S., Shapiro H., Lindquist E., Tice H., Dalin E., Glavina del Rio T.,
RA   Bruce D., Barry K., Pitluck S., Srivastava M., Simakov O., Chapman J.,
RA   Mitros T., Hellsten U., Putnam N.H., Fahey B., Gauthier M., Larroux C.,
RA   Richards G.S., Stanke M., Adamska M., Darling A., Dacre M., Degnan S.M.,
RA   Zhai Y., Adamski M., Calcino A., Cummins S.F., Goodstein D.M., Harris C.,
RA   Shu S., Woodcroft B., Leys S.P., Manning G., Degnan B.M., Rokhsar D.S.;
RT   "The genome of the haplosclerid demosponge Amphimedon queenslandica and the
RT   evolution of animal complexity.";
RL   Submitted (MAY-2010) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|EnsemblMetazoa:Aqu2.1.09297_001}
RP   IDENTIFICATION.
RG   EnsemblMetazoa;
RL   Submitted (MAY-2017) to UniProtKB.
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DR   EnsemblMetazoa; Aqu2.1.09297_001; Aqu2.1.09297_001; Aqu2.1.09297.
DR   InParanoid; A0A1X7T481; -.
DR   Proteomes; UP000007879; Unassembled WGS sequence.
DR   GO; GO:0000781; C:chromosome, telomeric region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   CDD; cd01670; Death; 1.
DR   Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   InterPro; IPR011029; DEATH-like_dom_sf.
DR   InterPro; IPR000488; Death_domain.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   Pfam; PF00531; Death; 1.
DR   SUPFAM; SSF47986; DEATH domain; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS50017; DEATH_DOMAIN; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000007879}.
FT   DOMAIN          754..816
FT                   /note="Death"
FT                   /evidence="ECO:0000259|PROSITE:PS50017"
FT   REGION          110..157
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        111..131
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        132..153
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1028 AA;  116512 MW;  71D1D3329D78FFAB CRC64;
     MLMFQHYRTC IHDYYNXTVE KWLSEGSIEL TVTRVNLHGP PGAGKTCAQD LLLNNPPTTH
     TTDSTPIARP AVKATRVSVD DEAMKWEKVD RDGLLERLAS DLKKAAASQP IEEISASQPK
     DNISSSFSMD KRQTAERCDE STEQDESDAK TDESTVASNE SFSIGEGVIQ EIVGTIQSSE
     VQLNLSDHWL YIIDSGGQPA YQELLPLFVR TASLNIITLN LSKPLDEKLD FQYRIGGKIF
     SCGLNLKYSN REFFLSAVSS GAILKPIDVP HALETPSHPM NFVLGTHYDL IKEDVHLLRK
     INDELRSLLD PGMKDFVVLD GEFMIFPINT LVPEDEGRMK AGQDLCQSIS NCGGTSLKIN
     VPIRWFAFEL WLQKIAEGNS RSFLIIDEAI SAGARLKMSE DDTKHALKYL HNVTIILYYP
     DILPQLVFVD PKPILEVLSR LLALSYVQRK ALHLIAKPVP LQKDLNRLHD FGLFKEELLM
     NHFKSLFSPP HFEPSHLLKL LIHLHIITKR EKGDYFFPCA LQSYTKPPEP QTETKALLIV
     WLKKLEEDDI RILRLPVPQG MFPLLITHLL NHKEDSCIVG FPPLDDPKYR YCNDQKHMCY
     KYCDALSLWI NIQEMRYTLH IINRYSHIEV YFVGSVQKAK ENCPYICELV MKAVSDSADA
     INVEHNHFAA FSCPNDKSCY CVVINDKEFK TKCMLCTCLT NISDDSYWCW FDCISKAVLT
     SDSQCLEEPQ EELNITDLDE ILTHLKKGHY PSSNWKELGL KLGLYDNTLS TIESNYSKVE
     DRLRECLAKW LQRADGVDAK GGATWTTLIN ALEQCDSGKP TAEPIRCEKI KGKADQSQTD
     DDELCNIKST TDYSIIGDRA YTITSLKQCL VHKGSVEETR LLSSTVQSQC IPQSESITDN
     TLLTLKDYGA SLLSYTGTIS KLLCTEGGVY ELDNKIKLLI HKDMVDYGLR VGSVITIDNV
     HLINEWFWRG FYCCIVSHLL VVSFSTDGTN HHQSLVPSRN RLIKFISQHS PLDKLWLLEA
     YTLLKNKL
//