ID A0A1X7TD20_AMPQE Unreviewed; 608 AA.
AC A0A1X7TD20;
DT 05-JUL-2017, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2017, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE RecName: Full=GRAM domain-containing protein {ECO:0000259|Pfam:PF02893};
GN Name=105315022 {ECO:0000313|EnsemblMetazoa:Aqu2.1.12240_001};
OS Amphimedon queenslandica (Sponge).
OC Eukaryota; Metazoa; Porifera; Demospongiae; Heteroscleromorpha;
OC Haplosclerida; Niphatidae; Amphimedon.
OX NCBI_TaxID=400682 {ECO:0000313|EnsemblMetazoa:Aqu2.1.12240_001, ECO:0000313|Proteomes:UP000007879};
RN [1] {ECO:0000313|Proteomes:UP000007879}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20686567; DOI=10.1038/nature09201;
RA Srivastava M., Simakov O., Chapman J., Fahey B., Gauthier M.E., Mitros T.,
RA Richards G.S., Conaco C., Dacre M., Hellsten U., Larroux C., Putnam N.H.,
RA Stanke M., Adamska M., Darling A., Degnan S.M., Oakley T.H.,
RA Plachetzki D.C., Zhai Y., Adamski M., Calcino A., Cummins S.F.,
RA Goodstein D.M., Harris C., Jackson D.J., Leys S.P., Shu S., Woodcroft B.J.,
RA Vervoort M., Kosik K.S., Manning G., Degnan B.M., Rokhsar D.S.;
RT "The Amphimedon queenslandica genome and the evolution of animal
RT complexity.";
RL Nature 466:720-726(2010).
RN [2] {ECO:0000313|Proteomes:UP000007879}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Lucas S., Shapiro H., Lindquist E., Tice H., Dalin E., Glavina del Rio T.,
RA Bruce D., Barry K., Pitluck S., Srivastava M., Simakov O., Chapman J.,
RA Mitros T., Hellsten U., Putnam N.H., Fahey B., Gauthier M., Larroux C.,
RA Richards G.S., Stanke M., Adamska M., Darling A., Dacre M., Degnan S.M.,
RA Zhai Y., Adamski M., Calcino A., Cummins S.F., Goodstein D.M., Harris C.,
RA Shu S., Woodcroft B., Leys S.P., Manning G., Degnan B.M., Rokhsar D.S.;
RT "The genome of the haplosclerid demosponge Amphimedon queenslandica and the
RT evolution of animal complexity.";
RL Submitted (MAY-2010) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EnsemblMetazoa:Aqu2.1.12240_001}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (MAY-2017) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_019860300.1; XM_020004741.1.
DR AlphaFoldDB; A0A1X7TD20; -.
DR STRING; 400682.A0A1X7TD20; -.
DR EnsemblMetazoa; Aqu2.1.12240_001; Aqu2.1.12240_001; Aqu2.1.12240.
DR GeneID; 105315022; -.
DR KEGG; aqu:105315022; -.
DR eggNOG; ENOG502QPMR; Eukaryota.
DR InParanoid; A0A1X7TD20; -.
DR OrthoDB; 3028864at2759; -.
DR Proteomes; UP000007879; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0006915; P:apoptotic process; IEA:InterPro.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR004182; GRAM.
DR InterPro; IPR037847; GRAMDC4.
DR InterPro; IPR011993; PH-like_dom_sf.
DR PANTHER; PTHR37402; GRAM DOMAIN-CONTAINING PROTEIN 4; 1.
DR PANTHER; PTHR37402:SF1; GRAM DOMAIN-CONTAINING PROTEIN 4; 1.
DR Pfam; PF02893; GRAM; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000007879};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 231..258
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 442..548
FT /note="GRAM"
FT /evidence="ECO:0000259|Pfam:PF02893"
FT REGION 568..608
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 568..597
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 608 AA; 69386 MW; 3F69BA4AC950C074 CRC64;
MIRRALIARR KEKERDSLRY TREEGDEDEL VDVEDKYEAI GIEEAEKLSA CDEKNEDTLS
TLEKVWDEAD KVVYEQQMEH LHDQLTAALI DNQELKMKLK SMESGEAKSQ EATAAKTKKY
GSYRGRDLSM STTREGFESV SSQPTIPTDI TSSRPSRYVR WWDRIKDNLF GILYDFTDDS
QTEEEEAKEA PLQYKLLREN LQRLRVSSKP YLDLLDTLIA IKDWKNPSLT LVIFLLYMYC
VWNGWLIQCL LLLAIIYLSL NYLRTTGLTE QFGFGSHPAR GSEDDTSETL RDKFQLMKHI
GQRVQNTSET VSDNLEKGQN LLEWYQPQST RKVYTMLCGA FIATLFIPND YSMTIAGLGI
GFKLFIVDNI YRKYPNVKKK YDGLARMWRS LPTHKDVITL QSMTEDEIRE HCESGSELSS
LTSSSSTISI RDTSFCERFQ LSFEETPLES WRSGKRCTLL DKDHPLTGSK QGRIFLTHSF
LCFERSPRPN DNADRFTISL GDISKICKAK PFAVLPGSGM SIEVTVKGRE KPYLFGAILH
RDQAYLSICD QAMIIGLPWG SDLDSSERQT FSTLSARDPS PSRERSGGNT SLEESAGDDN
AMTIGAHM
//
