ID A0A1X7TEU7_AMPQE Unreviewed; 744 AA.
AC A0A1X7TEU7;
DT 05-JUL-2017, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2017, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=MI domain-containing protein {ECO:0008006|Google:ProtNLM};
OS Amphimedon queenslandica (Sponge).
OC Eukaryota; Metazoa; Porifera; Demospongiae; Heteroscleromorpha;
OC Haplosclerida; Niphatidae; Amphimedon.
OX NCBI_TaxID=400682 {ECO:0000313|EnsemblMetazoa:Aqu2.1.13166_001, ECO:0000313|Proteomes:UP000007879};
RN [1] {ECO:0000313|Proteomes:UP000007879}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20686567; DOI=10.1038/nature09201;
RA Srivastava M., Simakov O., Chapman J., Fahey B., Gauthier M.E., Mitros T.,
RA Richards G.S., Conaco C., Dacre M., Hellsten U., Larroux C., Putnam N.H.,
RA Stanke M., Adamska M., Darling A., Degnan S.M., Oakley T.H.,
RA Plachetzki D.C., Zhai Y., Adamski M., Calcino A., Cummins S.F.,
RA Goodstein D.M., Harris C., Jackson D.J., Leys S.P., Shu S., Woodcroft B.J.,
RA Vervoort M., Kosik K.S., Manning G., Degnan B.M., Rokhsar D.S.;
RT "The Amphimedon queenslandica genome and the evolution of animal
RT complexity.";
RL Nature 466:720-726(2010).
RN [2] {ECO:0000313|Proteomes:UP000007879}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Lucas S., Shapiro H., Lindquist E., Tice H., Dalin E., Glavina del Rio T.,
RA Bruce D., Barry K., Pitluck S., Srivastava M., Simakov O., Chapman J.,
RA Mitros T., Hellsten U., Putnam N.H., Fahey B., Gauthier M., Larroux C.,
RA Richards G.S., Stanke M., Adamska M., Darling A., Dacre M., Degnan S.M.,
RA Zhai Y., Adamski M., Calcino A., Cummins S.F., Goodstein D.M., Harris C.,
RA Shu S., Woodcroft B., Leys S.P., Manning G., Degnan B.M., Rokhsar D.S.;
RT "The genome of the haplosclerid demosponge Amphimedon queenslandica and the
RT evolution of animal complexity.";
RL Submitted (MAY-2010) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EnsemblMetazoa:Aqu2.1.13166_001}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (MAY-2017) to UniProtKB.
CC -!- SIMILARITY: Belongs to the eukaryotic initiation factor 4G family.
CC {ECO:0000256|ARBA:ARBA00005775}.
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DR AlphaFoldDB; A0A1X7TEU7; -.
DR STRING; 400682.A0A1X7TEU7; -.
DR EnsemblMetazoa; Aqu2.1.13166_001; Aqu2.1.13166_001; Aqu2.1.13166.
DR eggNOG; KOG0401; Eukaryota.
DR InParanoid; A0A1X7TEU7; -.
DR Proteomes; UP000007879; Unassembled WGS sequence.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-KW.
DR CDD; cd11559; W2_eIF4G1_like; 1.
DR Gene3D; 1.25.40.180; -; 3.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR045208; IF4G.
DR InterPro; IPR003891; Initiation_fac_eIF4g_MI.
DR InterPro; IPR003890; MIF4G-like_typ-3.
DR InterPro; IPR003307; W2_domain.
DR PANTHER; PTHR23253; EUKARYOTIC TRANSLATION INITIATION FACTOR 4 GAMMA; 1.
DR PANTHER; PTHR23253:SF9; EUKARYOTIC TRANSLATION INITIATION FACTOR 4G1, ISOFORM B-RELATED; 1.
DR Pfam; PF02847; MA3; 1.
DR Pfam; PF02854; MIF4G; 1.
DR Pfam; PF02020; W2; 1.
DR SMART; SM00515; eIF5C; 1.
DR SMART; SM00544; MA3; 1.
DR SMART; SM00543; MIF4G; 1.
DR SUPFAM; SSF48371; ARM repeat; 3.
DR PROSITE; PS51366; MI; 1.
DR PROSITE; PS51363; W2; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000007879}.
FT DOMAIN 375..497
FT /note="MI"
FT /evidence="ECO:0000259|PROSITE:PS51366"
FT DOMAIN 575..741
FT /note="W2"
FT /evidence="ECO:0000259|PROSITE:PS51363"
FT REGION 192..374
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 211..240
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 246..260
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 300..332
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 744 AA; 83630 MW; 52C3162FA5B58279 CRC64;
IKVEIVKVDD NGDEVVKETT FRRELLTRCQ KEFEKDKRDD ETKEEMLKAL EEAAPEEKKL
KEAELKEWED KSRKRSLGNI RFIGELFKLK MLSESIMHEC IVRLLRSTSD EEALECFSRL
ITTTGKELDH PQAKQRMDRY FDRINEIIDK KKISSRIRFM LQDVQEMRKN DWVSRRQETL
KTIDQIHQEA EMEAMQEKEM IRSLQPVSGK QYARDDKKRS KGDDYSGSRK GDKATGGRRD
STPDVSRIQA LGNKREKTTP TLGPASLRPG GWKGGRSQGQ TPPPPASATT DVKDKGPASK
GPQRSSTSGT SKKSSTTTTA GGRGSQPQAT RRSQSDEKSD TLKLVKDFLN PQPPPATQAT
PTHTTSKQDR LTEEVVERKT TTIIDELSEN QDYKEAIECV IELESPGLMN VFVQTGINHS
LEKSSTVRVS VGKLFDTLVA KDLLTTEKLT SGLQVMLECG EDLEVDIPKV WDFFAEIVAP
LVSSSNLPLN NYVKLLREAN IEERKLSRNV ARTLKYCVDH SGSKEKVCQL WRGCGLRWTE
IGVSADDVVG FLKDEGVSFL DSTPAPSAAD SSGSELHSPD NPPYLNDLSL LFGSTVHTND
DILDLIEKKV SRSESKSEQF IRTLSRATVG GSTTGEGQST IYNDDMFAKR LPLLKKWVDQ
EEELQVVVLD AIQLEVNRLR HPPGLLHKIF SSLYSIEVIS ESAFLNWRDR GKEKAGRGVA
LQSSKKFFNW LEHAETESDN DVGS
//
