ID A0A1X7TFS3_AMPQE Unreviewed; 1315 AA.
AC A0A1X7TFS3;
DT 05-JUL-2017, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2017, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=Death domain-containing protein {ECO:0000259|PROSITE:PS50017};
OS Amphimedon queenslandica (Sponge).
OC Eukaryota; Metazoa; Porifera; Demospongiae; Heteroscleromorpha;
OC Haplosclerida; Niphatidae; Amphimedon.
OX NCBI_TaxID=400682 {ECO:0000313|EnsemblMetazoa:Aqu2.1.13531_001, ECO:0000313|Proteomes:UP000007879};
RN [1] {ECO:0000313|Proteomes:UP000007879}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20686567; DOI=10.1038/nature09201;
RA Srivastava M., Simakov O., Chapman J., Fahey B., Gauthier M.E., Mitros T.,
RA Richards G.S., Conaco C., Dacre M., Hellsten U., Larroux C., Putnam N.H.,
RA Stanke M., Adamska M., Darling A., Degnan S.M., Oakley T.H.,
RA Plachetzki D.C., Zhai Y., Adamski M., Calcino A., Cummins S.F.,
RA Goodstein D.M., Harris C., Jackson D.J., Leys S.P., Shu S., Woodcroft B.J.,
RA Vervoort M., Kosik K.S., Manning G., Degnan B.M., Rokhsar D.S.;
RT "The Amphimedon queenslandica genome and the evolution of animal
RT complexity.";
RL Nature 466:720-726(2010).
RN [2] {ECO:0000313|Proteomes:UP000007879}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Lucas S., Shapiro H., Lindquist E., Tice H., Dalin E., Glavina del Rio T.,
RA Bruce D., Barry K., Pitluck S., Srivastava M., Simakov O., Chapman J.,
RA Mitros T., Hellsten U., Putnam N.H., Fahey B., Gauthier M., Larroux C.,
RA Richards G.S., Stanke M., Adamska M., Darling A., Dacre M., Degnan S.M.,
RA Zhai Y., Adamski M., Calcino A., Cummins S.F., Goodstein D.M., Harris C.,
RA Shu S., Woodcroft B., Leys S.P., Manning G., Degnan B.M., Rokhsar D.S.;
RT "The genome of the haplosclerid demosponge Amphimedon queenslandica and the
RT evolution of animal complexity.";
RL Submitted (MAY-2010) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EnsemblMetazoa:Aqu2.1.13531_001}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (MAY-2017) to UniProtKB.
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DR EnsemblMetazoa; Aqu2.1.13531_001; Aqu2.1.13531_001; Aqu2.1.13531.
DR eggNOG; KOG0504; Eukaryota.
DR InParanoid; A0A1X7TFS3; -.
DR Proteomes; UP000007879; Unassembled WGS sequence.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd01670; Death; 1.
DR CDD; cd00882; Ras_like_GTPase; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 2.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR000488; Death_domain.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR24126:SF14; 26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 10-RELATED; 1.
DR PANTHER; PTHR24126; ANKYRIN REPEAT, PH AND SEC7 DOMAIN CONTAINING PROTEIN SECG-RELATED; 1.
DR Pfam; PF12796; Ank_2; 1.
DR Pfam; PF13857; Ank_5; 1.
DR Pfam; PF00531; Death; 1.
DR SMART; SM00248; ANK; 6.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF47986; DEATH domain; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 3.
DR PROSITE; PS50088; ANK_REPEAT; 4.
DR PROSITE; PS50017; DEATH_DOMAIN; 1.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|ARBA:ARBA00023043, ECO:0000256|PROSITE-
KW ProRule:PRU00023}; Reference proteome {ECO:0000313|Proteomes:UP000007879};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 28..105
FT /note="Death"
FT /evidence="ECO:0000259|PROSITE:PS50017"
FT REPEAT 599..631
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 735..757
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 769..792
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 835..859
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REGION 212..232
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1315 AA; 147172 MW; 75C3941F9C7765BD CRC64;
MATSMGSNLD IKDLIHIFDF LKECGFSGTK FHEFGLRLGL RKPTMDVIQY NHPHDASRSL
TECLDKWLSR ADDVDSKGGA TIDSLIHALV SMGETAAAEK LKILTIMENH LPSSQSLHDP
LSTVCLLHYR EHLLTEEVVT KVDSAPSIPD QCDVLFAAVT EAVQTDPNNL QTFARVLCKV
STNEQLGLAI KKDINKYFPH LQLGIEPQIM PSAPTGTNKE GRPLLSSDAL NDIPDDRPKV
SELIEFYELL IKGQLEESLP LLDADIIRKI RNAVNDQEGM SLLIRAFDEH PTLLYKMRAT
KTIEGLSQKT FETPPSSALQ LPQQPLLTTQ SLVATSNQSH SSQIQQHQSQ LMRNEPHPFP
STVIELSSKE EVACSIELLH HQFTSLVSKI RRLFIELVSN KEVEADDVAF HAEQFLGQDL
KLTEINISTI FNAIRPYCGL FNFRLLRSLV HHFIPLSNDL CTELTQYIDD LGKFSESAQL
KHIRSTIKEK LSSLPAVASP TTSDQTKPVV IKLNDGWEKI TKAQLEKVLK HYFGPDSDIF
SYISFDYGSF VVTLLIPTSL SQSLISTIND KRGSMNRLGI LEVAVDKSTI SIGKEEDNNF
EISLHQSVKA GDSFEVSMLL QLGADPNSKN KRGKSAIEIA NEEGHTQIKE ILLTGRGTQL
LKLFKDANYE DAIRLLPYIE NLQQLRDEVT IKISPFDTYQ VEANLLHMAS WNGWLDVTSD
LITKYDCDPQ EEDSNGNTCL HYAAMGNHVD VVKYLINECS SDPMATNEDG DTVLHKAAYY
GSLDVMKYLI DHHNSDLRAT NKKGETILHC TVEHVDILKY LIDECNCDPM TTTFYGRTPL
HYAANFDCSA SVEFLLSTGK CDPLAKDKDG KTPVRLAKER QQNGSTNTLP IFKKFGNIRS
SHPIDSYVNV ILVGSSGAGK STLSHVINNT ATFTLLGSFR NVGGVVPCTA GIIPYKLQHK
TLGNIILHDF AGHSEYYSSH STVIENLLQG SGGVFLIVVN ILEKEAVKQL HQWLTIVRHE
AQKALNQCHI IIIVSHVDKV KNFIERRRRK EEMQEIIVRE RCDSIFLDCR KLGGSGVDSF
FNKLSIACES IRSTIGRNLS LYCHMMYGLL EERKENILTL SDVMAAGEGN DDYVLPDKRE
DVLDILHSLH STGLMSILET IVERSPFLVT GTRRIGLKEI LPDESLSNIS SLSLLGGRDI
MEVIEITANF NTGTIKLDIK DLDVVIEELT ILNQLNCTKW FQFGLYLGLY DPRLVNIDID
YRGHSEKCFH ACMSAWLRGE DKVREKGGPS WSSLATALDT IEEKSIASYI RNKYC
//
