ID   A0A1X7TG38_AMPQE        Unreviewed;      1318 AA.
AC   A0A1X7TG38;
DT   05-JUL-2017, integrated into UniProtKB/TrEMBL.
DT   05-JUL-2017, sequence version 1.
DT   27-MAR-2024, entry version 18.
DE   RecName: Full=NACHT domain-containing protein {ECO:0000259|PROSITE:PS50837};
OS   Amphimedon queenslandica (Sponge).
OC   Eukaryota; Metazoa; Porifera; Demospongiae; Heteroscleromorpha;
OC   Haplosclerida; Niphatidae; Amphimedon.
OX   NCBI_TaxID=400682 {ECO:0000313|EnsemblMetazoa:Aqu2.1.13656_001, ECO:0000313|Proteomes:UP000007879};
RN   [1] {ECO:0000313|Proteomes:UP000007879}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=20686567; DOI=10.1038/nature09201;
RA   Srivastava M., Simakov O., Chapman J., Fahey B., Gauthier M.E., Mitros T.,
RA   Richards G.S., Conaco C., Dacre M., Hellsten U., Larroux C., Putnam N.H.,
RA   Stanke M., Adamska M., Darling A., Degnan S.M., Oakley T.H.,
RA   Plachetzki D.C., Zhai Y., Adamski M., Calcino A., Cummins S.F.,
RA   Goodstein D.M., Harris C., Jackson D.J., Leys S.P., Shu S., Woodcroft B.J.,
RA   Vervoort M., Kosik K.S., Manning G., Degnan B.M., Rokhsar D.S.;
RT   "The Amphimedon queenslandica genome and the evolution of animal
RT   complexity.";
RL   Nature 466:720-726(2010).
RN   [2] {ECO:0000313|Proteomes:UP000007879}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Lucas S., Shapiro H., Lindquist E., Tice H., Dalin E., Glavina del Rio T.,
RA   Bruce D., Barry K., Pitluck S., Srivastava M., Simakov O., Chapman J.,
RA   Mitros T., Hellsten U., Putnam N.H., Fahey B., Gauthier M., Larroux C.,
RA   Richards G.S., Stanke M., Adamska M., Darling A., Dacre M., Degnan S.M.,
RA   Zhai Y., Adamski M., Calcino A., Cummins S.F., Goodstein D.M., Harris C.,
RA   Shu S., Woodcroft B., Leys S.P., Manning G., Degnan B.M., Rokhsar D.S.;
RT   "The genome of the haplosclerid demosponge Amphimedon queenslandica and the
RT   evolution of animal complexity.";
RL   Submitted (MAY-2010) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|EnsemblMetazoa:Aqu2.1.13656_001}
RP   IDENTIFICATION.
RG   EnsemblMetazoa;
RL   Submitted (MAY-2017) to UniProtKB.
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DR   EnsemblMetazoa; Aqu2.1.13656_001; Aqu2.1.13656_001; Aqu2.1.13656.
DR   eggNOG; ENOG502QTJW; Eukaryota.
DR   InParanoid; A0A1X7TG38; -.
DR   Proteomes; UP000007879; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   InterPro; IPR007111; NACHT_NTPase.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR45690; NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 12; 1.
DR   PANTHER; PTHR45690:SF15; NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 14; 1.
DR   Pfam; PF05729; NACHT; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   SUPFAM; SSF52047; RNI-like; 1.
DR   PROSITE; PS50837; NACHT; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007879};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        55..77
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          347..467
FT                   /note="NACHT"
FT                   /evidence="ECO:0000259|PROSITE:PS50837"
SQ   SEQUENCE   1318 AA;  149988 MW;  AE205C5A04E05312 CRC64;
     MIDVSQWRAS IGLWNYCQAA SSRPANGRHS HSFKAAVDSK AGSTTSGEKT SKLPAALSLI
     AFLLFFFLFL SLLRHILIIP LTGNCYQVQC TTGVTVTDTN YLQSVVLPGG SSSNLIYNDL
     YLIVCLRKLL LLSGDVELNP GPITGNPEDI LRTHSAKLTD AITTNLYKVT DALYAKGLIP
     LDTKDNIQTV TGISHYRKSS QLVSVIQQQL ESSLNPEQYL IDICHVLINQ QHRTLTDIAT
     SILHQLGQSI PDNVTSISSI PDDVQGYADN MRQRYKHQPV VATDWPPRIG KDYFGRLALV
     ETQDSSTQAE SAWHMLRGQV DKTVKLTGHK EIRVEDVLKH TDSPLSLRVV IDGPPGIGKT
     TLCCKLLNMW SNGPLVHHQY DLVLYCSFRN SKIATATTLA DLFVRQRYEV PMVSEWFEKR
     DGEGLLIIFD GWDELSEQLR QSSLAASIIH RKQLDQCSVI VTSRSYASSS LLKMDTLSRH
     VQIIGFSKEE VSTVIIQTIQ KDTKLAQELI DENTNSWNQY KSHFTTTQSS EDSKLAVKLI
     NDLKVRNDVQ SLCYVPLVCS MVILVYCKEG GHLPTTLTQL YENFILQTIR RHVKRHDINP
     RTLASLSSLP SQLAKPLQEM CQLAYTNLVD TRMTFSSHQL QSLSEAVKED YLGLMTTFID
     KDMEKYQFLH LSIQEFLAAW WIAKHEKKRE EVFKDHFDDD HFRMCLRFLA GLTHLEHESY
     QQYFNKQQLD LQCKRKPMFG FETFHLSYFY QNPEFNECGH IRSDDFDNVP ILLLQLLYES
     QNKTLCQVLA QFIKNHSLCL DRVSLSLFDW LCLSYFMNNS NTTWNYLHLG EIPHQSLSVF
     TAGLTNNSLQ IQCKRLELRL DEPTDESLDK LLQSSLLYNM QECYCELSFG QYVPCLVLLQ
     FLNLPQLKIL HLIIENSAIP TVNNTDYTDK CTALEKCIEI NSTLQEMKVE YNESEEVTST
     IPSVIRGVTR NKTIVSLTLG ISGATFSPLP DGVIEQLLKD NNTLQALSLN IPDRLLQSSL
     NIVEVNTPLT ALEIGEESNA LLTSSLLPHI KGLHCLILHE PYPHLLFLSH PSLHTLTLPL
     DTAKSAIELF SNLRTNTTLK ALSVEIKKER AYTSSMGTSL QDMLTQNQTL KYLEIDNNRY
     IISISFLSFL ATGLRHNTSL QQLSVSIPLS LNEEIRTFIN VISQKNNLTE LKVSFKPDQS
     YSNNSRKEKE QIMTPLFYEQ VLPAVTNMLQ SHTTIRLLRL ECEYIDVWSS QPNWIKLVQH
     LYETIFTNPS LEYIEISTES TLLVDTLKDQ KTTLIDRHRK EQPHKLLPFF NLAEITSE
//