ID A0A1X7TID8_AMPQE Unreviewed; 958 AA.
AC A0A1X7TID8;
DT 05-JUL-2017, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2017, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE RecName: Full=EGF-like domain-containing protein {ECO:0000259|PROSITE:PS50026};
OS Amphimedon queenslandica (Sponge).
OC Eukaryota; Metazoa; Porifera; Demospongiae; Heteroscleromorpha;
OC Haplosclerida; Niphatidae; Amphimedon.
OX NCBI_TaxID=400682 {ECO:0000313|EnsemblMetazoa:Aqu2.1.14434_001, ECO:0000313|Proteomes:UP000007879};
RN [1] {ECO:0000313|Proteomes:UP000007879}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20686567; DOI=10.1038/nature09201;
RA Srivastava M., Simakov O., Chapman J., Fahey B., Gauthier M.E., Mitros T.,
RA Richards G.S., Conaco C., Dacre M., Hellsten U., Larroux C., Putnam N.H.,
RA Stanke M., Adamska M., Darling A., Degnan S.M., Oakley T.H.,
RA Plachetzki D.C., Zhai Y., Adamski M., Calcino A., Cummins S.F.,
RA Goodstein D.M., Harris C., Jackson D.J., Leys S.P., Shu S., Woodcroft B.J.,
RA Vervoort M., Kosik K.S., Manning G., Degnan B.M., Rokhsar D.S.;
RT "The Amphimedon queenslandica genome and the evolution of animal
RT complexity.";
RL Nature 466:720-726(2010).
RN [2] {ECO:0000313|Proteomes:UP000007879}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Lucas S., Shapiro H., Lindquist E., Tice H., Dalin E., Glavina del Rio T.,
RA Bruce D., Barry K., Pitluck S., Srivastava M., Simakov O., Chapman J.,
RA Mitros T., Hellsten U., Putnam N.H., Fahey B., Gauthier M., Larroux C.,
RA Richards G.S., Stanke M., Adamska M., Darling A., Dacre M., Degnan S.M.,
RA Zhai Y., Adamski M., Calcino A., Cummins S.F., Goodstein D.M., Harris C.,
RA Shu S., Woodcroft B., Leys S.P., Manning G., Degnan B.M., Rokhsar D.S.;
RT "The genome of the haplosclerid demosponge Amphimedon queenslandica and the
RT evolution of animal complexity.";
RL Submitted (MAY-2010) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EnsemblMetazoa:Aqu2.1.14434_001}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (MAY-2017) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR AlphaFoldDB; A0A1X7TID8; -.
DR STRING; 400682.A0A1X7TID8; -.
DR EnsemblMetazoa; Aqu2.1.14434_001; Aqu2.1.14434_001; Aqu2.1.14434.
DR InParanoid; A0A1X7TID8; -.
DR Proteomes; UP000007879; Unassembled WGS sequence.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR Gene3D; 2.10.25.10; Laminin; 23.
DR InterPro; IPR026823; cEGF.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR PANTHER; PTHR24034; EGF-LIKE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR24034:SF166; VACUOLAR-SORTING RECEPTOR 1; 1.
DR Pfam; PF12662; cEGF; 5.
DR Pfam; PF07645; EGF_CA; 11.
DR Pfam; PF14670; FXa_inhibition; 5.
DR SMART; SM00181; EGF; 23.
DR SMART; SM00179; EGF_CA; 23.
DR SUPFAM; SSF57196; EGF/Laminin; 2.
DR SUPFAM; SSF57184; Growth factor receptor domain; 7.
DR PROSITE; PS00010; ASX_HYDROXYL; 15.
DR PROSITE; PS01186; EGF_2; 12.
DR PROSITE; PS50026; EGF_3; 9.
DR PROSITE; PS01187; EGF_CA; 3.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Extracellular matrix {ECO:0000256|ARBA:ARBA00022530};
KW Reference proteome {ECO:0000313|Proteomes:UP000007879};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022530}.
FT DOMAIN 244..281
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 282..318
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 406..446
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 447..483
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 488..528
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 653..690
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 691..731
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 836..872
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 877..917
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
SQ SEQUENCE 958 AA; 103711 MW; 3ED43E6D6DB56758 CRC64;
MNECIDSDCE QICNNTVGSY TCSCNNGYSL NSDGRNCSDI NECTTNNGGC EHICINKIPL
FDCLCMNGFR LQNEKFCSDI NECLEQTSGC SHDCDNTEGS YLCSCPTGYL LEPDNHTCTD
INECIINNGG CEEICDNTNG SYTCSCETGY TVDESGHNCT DIDECSSNNG GCDQICINLE
GTHNCSCRSG YIMAANGVSC IDINECNDNN GGCSQICSNT NGSYSCECNN GYRFIENSTT
NCTDTNECLV NNGDCQQLCT NINGSFYCSC ISGYNGSVFC EDIDECQLEI SKCNQTCTNT
VGSYYCECES GYTLSSDSYS CIDNDECVMG TDICDQVCIN NPGSYHCSCN TGYSLKSNGI
SCRDNDECQI NPDICDQTCM NTDGSFYCEC YSGYRLDTQT NNTCSDIDEC IEGTSGCDQM
CNNTIGSYNC SCMPGYQLNS DDHNCDDVNE CTINNGECEQ ICMNTNGGHY CMCQEGYSFN
NSDTNCTDNN ECIKDNGGCD HTCTNIVGSY ICSCDTGYSL NTDEHNCTDI NECDSSNGGC
DQICKNVPGS HYCNCKVGYI LHSNGSACID IDECSVNNGN CDQICTNFEG THNCSCRSGY
IMSANGTSCI DINECVDNNG DCSQICSNTD GSFECECHDG YGFIENSTTD CIDTNECLVN
NGDCQQFCIN TNGSYYCSCK AGYDGSVFCE DINECNLEIS GCNQTCINTV GSYYCQCLSG
YTLSNDSHFC TDNDECLMGT DICDQVCINN PGSYHCSCNT GYSLKSNAIS CLDIDECQIN
PNICDQSCMN TDGSYIDECI EGTSGCDQIC NNTIGSYNCS CMPGYQLNSD DHNCDDVNEC
TINNGGCEQT CINTKGGHYC MCQEGYSFNN SDTSCTDNNE CIEDNGGCDH TCTNTVGSYI
CSCDTGYSLN TDEHNCTDIN ECDSSNGGCD QICKNVPGSH YCNCKVGYTL HSNGSTCI
//
