ID A0A1X7TPU4_AMPQE Unreviewed; 682 AA.
AC A0A1X7TPU4;
DT 05-JUL-2017, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2017, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=BED-type domain-containing protein {ECO:0008006|Google:ProtNLM};
OS Amphimedon queenslandica (Sponge).
OC Eukaryota; Metazoa; Porifera; Demospongiae; Heteroscleromorpha;
OC Haplosclerida; Niphatidae; Amphimedon.
OX NCBI_TaxID=400682 {ECO:0000313|EnsemblMetazoa:Aqu2.1.17103_001, ECO:0000313|Proteomes:UP000007879};
RN [1] {ECO:0000313|Proteomes:UP000007879}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20686567; DOI=10.1038/nature09201;
RA Srivastava M., Simakov O., Chapman J., Fahey B., Gauthier M.E., Mitros T.,
RA Richards G.S., Conaco C., Dacre M., Hellsten U., Larroux C., Putnam N.H.,
RA Stanke M., Adamska M., Darling A., Degnan S.M., Oakley T.H.,
RA Plachetzki D.C., Zhai Y., Adamski M., Calcino A., Cummins S.F.,
RA Goodstein D.M., Harris C., Jackson D.J., Leys S.P., Shu S., Woodcroft B.J.,
RA Vervoort M., Kosik K.S., Manning G., Degnan B.M., Rokhsar D.S.;
RT "The Amphimedon queenslandica genome and the evolution of animal
RT complexity.";
RL Nature 466:720-726(2010).
RN [2] {ECO:0000313|Proteomes:UP000007879}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Lucas S., Shapiro H., Lindquist E., Tice H., Dalin E., Glavina del Rio T.,
RA Bruce D., Barry K., Pitluck S., Srivastava M., Simakov O., Chapman J.,
RA Mitros T., Hellsten U., Putnam N.H., Fahey B., Gauthier M., Larroux C.,
RA Richards G.S., Stanke M., Adamska M., Darling A., Dacre M., Degnan S.M.,
RA Zhai Y., Adamski M., Calcino A., Cummins S.F., Goodstein D.M., Harris C.,
RA Shu S., Woodcroft B., Leys S.P., Manning G., Degnan B.M., Rokhsar D.S.;
RT "The genome of the haplosclerid demosponge Amphimedon queenslandica and the
RT evolution of animal complexity.";
RL Submitted (MAY-2010) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EnsemblMetazoa:Aqu2.1.17103_001}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (MAY-2017) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR AlphaFoldDB; A0A1X7TPU4; -.
DR EnsemblMetazoa; Aqu2.1.17103_001; Aqu2.1.17103_001; Aqu2.1.17103.
DR eggNOG; KOG1121; Eukaryota.
DR InParanoid; A0A1X7TPU4; -.
DR Proteomes; UP000007879; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR Gene3D; 2.130.10.30; Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II; 1.
DR InterPro; IPR008906; HATC_C_dom.
DR InterPro; IPR009091; RCC1/BLIP-II.
DR InterPro; IPR000408; Reg_chr_condens.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR003656; Znf_BED.
DR PANTHER; PTHR46169; DNA REPLICATION-RELATED ELEMENT FACTOR, ISOFORM A; 1.
DR PANTHER; PTHR46169:SF27; ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 4; 1.
DR Pfam; PF05699; Dimer_Tnp_hAT; 1.
DR Pfam; PF00415; RCC1; 1.
DR Pfam; PF02892; zf-BED; 1.
DR SUPFAM; SSF140996; Hermes dimerisation domain; 1.
DR SUPFAM; SSF50985; RCC1/BLIP-II; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR PROSITE; PS50012; RCC1_3; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000007879};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT REPEAT 34..85
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT DOMAIN 98..130
FT /note="BED-type"
FT /evidence="ECO:0000259|Pfam:PF02892"
FT DOMAIN 597..677
FT /note="HAT C-terminal dimerisation"
FT /evidence="ECO:0000259|Pfam:PF05699"
SQ SEQUENCE 682 AA; 75899 MW; 4F27C0BFE77F8A44 CRC64;
MIACEGSHAI ALNSKGQVFS WGTSPQACLG HEDAVLFMWG WGARSQLGQD EQKSLLSPTP
VNGFNEQPLE DVSCSYGHTA AITANDVAYC WDDNARGKNY KAKCKHCGSM ISASTKTCSN
FTTHLKRKHP NAFLMPQAPA VPAQGPKADA QGGKYREGDP RQKKITDLLI YLIAKDMLSP
SLVESDAFIQ FVSTLDQQYQ LPSQKHLMTT LLTEKCTVID DRLKQLLGKM DRVCITLDLC
SNLQMKGYLA ITCHFIQDWS IQSVLLGCMS FFGCHTADNI ARRCHETLDH YSLAEKISNI
ITDNASTVLN VFRLPGFDDC SSPALLGEFN DVEADENEIE AVNLSECMAL LPQHDSCFAH
TIQLVVKDGI KNARAINEVL TKAANIVSCT QKSINTSDML EGEGQAQANI AKGWNSDIKV
IRSLLSVPVE NLQLLDCQQL SSYERVMLND LIEILIPFEE ATDALQEQDI VTGSFVIPCI
RGLQAALDSL KLKHKSAIVT DLLASLNYRM SCYESRDHFI CAAILDPRFK LVWCSSNEEK
MNMKSKFIEI MSNEFDNEEL SSTSSAAGDS VQQPQPKRRK LFSYLPSTKT SSRINIEVDL
YLSEPALPEE AKPLDFWKLN ESKFPKLSRM AKYYLSIPAS SAPVERLFSI IAGKIFRQDR
CSMTDAVFQK LIAIKYNGHI IN
//
