ID A0A1X7TR81_AMPQE Unreviewed; 1451 AA.
AC A0A1X7TR81;
DT 05-JUL-2017, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2017, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=HMCN {ECO:0008006|Google:ProtNLM};
OS Amphimedon queenslandica (Sponge).
OC Eukaryota; Metazoa; Porifera; Demospongiae; Heteroscleromorpha;
OC Haplosclerida; Niphatidae; Amphimedon.
OX NCBI_TaxID=400682 {ECO:0000313|EnsemblMetazoa:Aqu2.1.17462_001, ECO:0000313|Proteomes:UP000007879};
RN [1] {ECO:0000313|Proteomes:UP000007879}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20686567; DOI=10.1038/nature09201;
RA Srivastava M., Simakov O., Chapman J., Fahey B., Gauthier M.E., Mitros T.,
RA Richards G.S., Conaco C., Dacre M., Hellsten U., Larroux C., Putnam N.H.,
RA Stanke M., Adamska M., Darling A., Degnan S.M., Oakley T.H.,
RA Plachetzki D.C., Zhai Y., Adamski M., Calcino A., Cummins S.F.,
RA Goodstein D.M., Harris C., Jackson D.J., Leys S.P., Shu S., Woodcroft B.J.,
RA Vervoort M., Kosik K.S., Manning G., Degnan B.M., Rokhsar D.S.;
RT "The Amphimedon queenslandica genome and the evolution of animal
RT complexity.";
RL Nature 466:720-726(2010).
RN [2] {ECO:0000313|Proteomes:UP000007879}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Lucas S., Shapiro H., Lindquist E., Tice H., Dalin E., Glavina del Rio T.,
RA Bruce D., Barry K., Pitluck S., Srivastava M., Simakov O., Chapman J.,
RA Mitros T., Hellsten U., Putnam N.H., Fahey B., Gauthier M., Larroux C.,
RA Richards G.S., Stanke M., Adamska M., Darling A., Dacre M., Degnan S.M.,
RA Zhai Y., Adamski M., Calcino A., Cummins S.F., Goodstein D.M., Harris C.,
RA Shu S., Woodcroft B., Leys S.P., Manning G., Degnan B.M., Rokhsar D.S.;
RT "The genome of the haplosclerid demosponge Amphimedon queenslandica and the
RT evolution of animal complexity.";
RL Submitted (MAY-2010) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EnsemblMetazoa:Aqu2.1.17462_001}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (MAY-2017) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR EnsemblMetazoa; Aqu2.1.17462_001; Aqu2.1.17462_001; Aqu2.1.17462.
DR InParanoid; A0A1X7TR81; -.
DR Proteomes; UP000007879; Unassembled WGS sequence.
DR CDD; cd00054; EGF_CA; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 12.
DR Gene3D; 2.10.25.10; Laminin; 3.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR001368; TNFR/NGFR_Cys_rich_reg.
DR PANTHER; PTHR12231; CTX-RELATED TYPE I TRANSMEMBRANE PROTEIN; 1.
DR PANTHER; PTHR12231:SF253; NEURAL CELL ADHESION MOLECULE; 1.
DR Pfam; PF07679; I-set; 5.
DR Pfam; PF13927; Ig_3; 6.
DR SMART; SM00181; EGF; 3.
DR SMART; SM00409; IG; 12.
DR SMART; SM00408; IGc2; 12.
DR SUPFAM; SSF57196; EGF/Laminin; 2.
DR SUPFAM; SSF48726; Immunoglobulin; 12.
DR PROSITE; PS00022; EGF_1; 1.
DR PROSITE; PS50026; EGF_3; 3.
DR PROSITE; PS50835; IG_LIKE; 12.
DR PROSITE; PS00652; TNFR_NGFR_1; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076};
KW Reference proteome {ECO:0000313|Proteomes:UP000007879};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..1451
FT /note="HMCN"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5012553053"
FT DOMAIN 108..196
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 201..293
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 297..388
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 412..451
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 458..548
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 550..643
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 647..739
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 765..803
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 810..898
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 902..995
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1007..1091
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1117..1156
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1163..1253
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1256..1348
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1360..1431
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DISULFID 421..438
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 774..791
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 793..802
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1126..1143
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 1451 AA; 156697 MW; 3B348ADF7F67D674 CRC64;
MFFAMLLCLT YSLHFSIQSP ILSPFSTTQR ENEDKNSSTN SDDWSTAAST HVVGILPMLS
TESISLVITT PETETVSFTV SSLTQTIAKG SVTAGTPTTI SDTSFAAPNI SALVSYVAVL
NGSSVTLRCV LHHAGNPGAT IQWTFDRSVI TNDSLFLISE GSTRLDITNI TTSYSGAYHC
NASNVAGASV ATINVDVQEP PYFIATPPHN VSVRYDNAIT LNCSSGGVPL PNITWFKDGI
VIPTDQYTSS NQSDTLITML TVVGSLTSHG YYTCQAVNDL VERRIINTSV NATVFEPISY
VGSTSNVTLN QSDTFSVICS FSGFPLPVVS WYFLNNFTYL SNNSRVSITT SSEEIIVTST
LTIRNVDKST DEGIYHCIGS SSYTAYISLC IVCNNSCEAG YTLNTTICTC SLSNICELSP
CQNGGSCTLV SAPSNYTCDC TDTDYVGINC TEFNYIVPNI SVPVSYIALL AGSSVSLRCV
LNEVGNPKAT IQWTFAGSVI TNNSLFLITE GSTRLDITNI TTSYSGAYHC NASNVAGSSV
ARINVDVQEP SFFIVTPLHN VSVRYNDSIT LNCSSGGVPL PNITWFKDGI VIPTDQYTSS
NQSDTLITML TIVGSLTSHG YYTCQAVNDL VERRVINTTV NLTVFEPLSY VRTDPPSSSI
TLNQSDTFTA DCSFSGLPLP VVSWYFLNNF LSNIGRVSIT TDTQEITVTS TLRIRNVKKS
TDEGVYHCIG IQASTYNVSK SLYIVCNNSC EVGYTLNTTT CTCSLSNICL LSPCQNGGSC
TLVSAPSNYT CDCGSDYVGF NCTDFNYIVP NISVPVSYVA LLAGSSVTLR CVLNEVGNPK
ATIQWTFAGS VITNNSLFLI TEGSTRLNIT SITTSYSGAY NCNASNVAGA SVATINVDVQ
EPSYFIVTPP HNVSVRYNNS ITLNCSSGGV PLPNITWFKD SIVIPIDQYT SSNQSDTLIT
MLTVVGSLTS HGYYTCQAVN DLVERRVINT TVNVSVFEPL SYVGIDPPSS SITLNQSDTF
TANCSFSGLP LPVVSWYFLN KFLSNIGKVS ITTDTQDITV TSTLRIRNVK KSTDEGVYHC
IGIEASTYNV SKSLYIVCNN SCKAGYTLNT TTCTCSLSNI CELSPCQNGG RCTLVSAPSI
YTCDCTGTDY VGINCTEFNY IVPYISVPVS YVALLAGSSV TLRCVLNEVG NPKATIQWTF
ARSVITNNSL FLINEGSTRL AITNITTSYS GAYHCNASNV AGTSVATINV DVQEPPYFIA
TPPHNVSVRY NNAITLNCSS GGVPLSNITW LKDGIVIPTD QYTSSNQSDT LITMLTVVGS
LTSHGYYTCQ AFNDLVESRI INTSVNVTVF EPLSYDESDP LSTHITLKQS DTFTVHCSFS
GLPLPVIFWF SHNGFLSNNS RVSITTDIQE ITVTSTLTIK NVNKSTDEGF YFYIGFQSHK
NYFNHTYLNI Q
//
