ID A0A1X7TUG0_AMPQE Unreviewed; 669 AA.
AC A0A1X7TUG0;
DT 05-JUL-2017, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2017, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE RecName: Full=RRM domain-containing protein {ECO:0000259|PROSITE:PS50102};
GN Name=100637891 {ECO:0000313|EnsemblMetazoa:Aqu2.1.18814_001};
OS Amphimedon queenslandica (Sponge).
OC Eukaryota; Metazoa; Porifera; Demospongiae; Heteroscleromorpha;
OC Haplosclerida; Niphatidae; Amphimedon.
OX NCBI_TaxID=400682 {ECO:0000313|EnsemblMetazoa:Aqu2.1.18814_001, ECO:0000313|Proteomes:UP000007879};
RN [1] {ECO:0000313|Proteomes:UP000007879}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20686567; DOI=10.1038/nature09201;
RA Srivastava M., Simakov O., Chapman J., Fahey B., Gauthier M.E., Mitros T.,
RA Richards G.S., Conaco C., Dacre M., Hellsten U., Larroux C., Putnam N.H.,
RA Stanke M., Adamska M., Darling A., Degnan S.M., Oakley T.H.,
RA Plachetzki D.C., Zhai Y., Adamski M., Calcino A., Cummins S.F.,
RA Goodstein D.M., Harris C., Jackson D.J., Leys S.P., Shu S., Woodcroft B.J.,
RA Vervoort M., Kosik K.S., Manning G., Degnan B.M., Rokhsar D.S.;
RT "The Amphimedon queenslandica genome and the evolution of animal
RT complexity.";
RL Nature 466:720-726(2010).
RN [2] {ECO:0000313|Proteomes:UP000007879}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Lucas S., Shapiro H., Lindquist E., Tice H., Dalin E., Glavina del Rio T.,
RA Bruce D., Barry K., Pitluck S., Srivastava M., Simakov O., Chapman J.,
RA Mitros T., Hellsten U., Putnam N.H., Fahey B., Gauthier M., Larroux C.,
RA Richards G.S., Stanke M., Adamska M., Darling A., Dacre M., Degnan S.M.,
RA Zhai Y., Adamski M., Calcino A., Cummins S.F., Goodstein D.M., Harris C.,
RA Shu S., Woodcroft B., Leys S.P., Manning G., Degnan B.M., Rokhsar D.S.;
RT "The genome of the haplosclerid demosponge Amphimedon queenslandica and the
RT evolution of animal complexity.";
RL Submitted (MAY-2010) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EnsemblMetazoa:Aqu2.1.18814_001}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (MAY-2017) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_003389772.2; XM_003389724.2.
DR AlphaFoldDB; A0A1X7TUG0; -.
DR STRING; 400682.A0A1X7TUG0; -.
DR EnsemblMetazoa; Aqu2.1.18814_001; Aqu2.1.18814_001; Aqu2.1.18814.
DR GeneID; 100637891; -.
DR KEGG; aqu:100637891; -.
DR eggNOG; KOG0117; Eukaryota.
DR InParanoid; A0A1X7TUG0; -.
DR OrthoDB; 3184171at2759; -.
DR Proteomes; UP000007879; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR CDD; cd19872; DSRM_A1CF-like; 1.
DR CDD; cd12249; RRM1_hnRNPR_like; 1.
DR CDD; cd12250; RRM2_hnRNPR_like; 1.
DR Gene3D; 3.30.160.20; -; 1.
DR Gene3D; 3.30.70.330; -; 3.
DR InterPro; IPR006535; HnRNP_R/Q_splicing_fac.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR000504; RRM_dom.
DR NCBIfam; TIGR01648; hnRNP-R-Q; 1.
DR PANTHER; PTHR21245:SF8; APOBEC1 COMPLEMENTATION FACTOR; 1.
DR PANTHER; PTHR21245; HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN; 1.
DR Pfam; PF14709; DND1_DSRM; 1.
DR Pfam; PF00076; RRM_1; 3.
DR SMART; SM00360; RRM; 3.
DR SUPFAM; SSF54768; dsRNA-binding domain-like; 1.
DR SUPFAM; SSF54928; RNA-binding domain, RBD; 2.
DR PROSITE; PS50102; RRM; 3.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000007879};
KW RNA-binding {ECO:0000256|PROSITE-ProRule:PRU00176}.
FT DOMAIN 102..181
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT DOMAIN 183..265
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT DOMAIN 278..348
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT REGION 1..69
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 350..370
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 13..27
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 28..51
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 52..69
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 669 AA; 73793 MW; B252141775DECE79 CRC64;
MERKRSGASN KKKSVASKET TPSSTEEETS GETKDTSSRS SLRDERDTRG SVSPRPVSST
STSPSPIAQL MTRTGYSIYQ QNNQRRYGPP PGWTGPPPKK GCEIFIGKIP RDCFEDELVP
IVEKAGPVYE MRLMMDHSGS MNRGYAFVVY CKAQDAKKSV KLLNEYEIRK GRTIGVCMSV
DNCRLFVGGI PKCLTKENIR EEMEKVTDGV ADIIMYPAAS DKSKNRGFAF VEYASHRAAA
MARRKLINSR VRLWNHVVAV DWAEPELEVD EETMATVKIL YVRNLMLTTT EAQLNKAFSH
HAPVERVKKI RDYAFVHFNS RSGALTAMKA MNGSVLDDAV IEVTLAKPVD KEAQMRNPPR
HQKSPSPPTI PPPYGILPID YSMLPSLYFP PSPKVFSRNS MGNKVVRTPP NSKGKSQSFY
PPHSLSFGHP QAQLVFPASP VQGPYMAQYM DSPKRPQISE EAAIFDVIPG LDISPAHPHQ
APPSQHPLPP SSFPVKQPRL LMQILEDLCM KSNWGQPLYC LHSTSTSPEG SLFQYKVYIP
ALSTTYIPSK LSRSVEEAQC TAAEYALVQM GLSIEGASYP TLAGVPPPPP LAPVDPLAPV
TIQPAQNPHH GFVGLPATPK TLSSRPAPPT WSPDPALITG FEATPFPIPP PPPHLAFSPH
TELYHHRGF
//
