ID A0A1X7TVQ6_AMPQE Unreviewed; 1602 AA.
AC A0A1X7TVQ6;
DT 05-JUL-2017, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2017, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=Caspase family p20 domain-containing protein {ECO:0008006|Google:ProtNLM};
OS Amphimedon queenslandica (Sponge).
OC Eukaryota; Metazoa; Porifera; Demospongiae; Heteroscleromorpha;
OC Haplosclerida; Niphatidae; Amphimedon.
OX NCBI_TaxID=400682 {ECO:0000313|EnsemblMetazoa:Aqu2.1.18994_001, ECO:0000313|Proteomes:UP000007879};
RN [1] {ECO:0000313|Proteomes:UP000007879}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20686567; DOI=10.1038/nature09201;
RA Srivastava M., Simakov O., Chapman J., Fahey B., Gauthier M.E., Mitros T.,
RA Richards G.S., Conaco C., Dacre M., Hellsten U., Larroux C., Putnam N.H.,
RA Stanke M., Adamska M., Darling A., Degnan S.M., Oakley T.H.,
RA Plachetzki D.C., Zhai Y., Adamski M., Calcino A., Cummins S.F.,
RA Goodstein D.M., Harris C., Jackson D.J., Leys S.P., Shu S., Woodcroft B.J.,
RA Vervoort M., Kosik K.S., Manning G., Degnan B.M., Rokhsar D.S.;
RT "The Amphimedon queenslandica genome and the evolution of animal
RT complexity.";
RL Nature 466:720-726(2010).
RN [2] {ECO:0000313|Proteomes:UP000007879}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Lucas S., Shapiro H., Lindquist E., Tice H., Dalin E., Glavina del Rio T.,
RA Bruce D., Barry K., Pitluck S., Srivastava M., Simakov O., Chapman J.,
RA Mitros T., Hellsten U., Putnam N.H., Fahey B., Gauthier M., Larroux C.,
RA Richards G.S., Stanke M., Adamska M., Darling A., Dacre M., Degnan S.M.,
RA Zhai Y., Adamski M., Calcino A., Cummins S.F., Goodstein D.M., Harris C.,
RA Shu S., Woodcroft B., Leys S.P., Manning G., Degnan B.M., Rokhsar D.S.;
RT "The genome of the haplosclerid demosponge Amphimedon queenslandica and the
RT evolution of animal complexity.";
RL Submitted (MAY-2010) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EnsemblMetazoa:Aqu2.1.18994_001}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (MAY-2017) to UniProtKB.
CC -!- SIMILARITY: Belongs to the peptidase C14A family.
CC {ECO:0000256|ARBA:ARBA00010134, ECO:0000256|RuleBase:RU003971}.
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DR STRING; 400682.A0A1X7TVQ6; -.
DR EnsemblMetazoa; Aqu2.1.18994_001; Aqu2.1.18994_001; Aqu2.1.18994.
DR eggNOG; KOG3573; Eukaryota.
DR InParanoid; A0A1X7TVQ6; -.
DR Proteomes; UP000007879; Unassembled WGS sequence.
DR GO; GO:0004197; F:cysteine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR Gene3D; 3.40.50.1460; -; 1.
DR Gene3D; 3.30.70.1470; Caspase-like; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 2.
DR InterPro; IPR029030; Caspase-like_dom_sf.
DR InterPro; IPR032171; COR.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011600; Pept_C14_caspase.
DR InterPro; IPR002138; Pept_C14_p10.
DR InterPro; IPR001309; Pept_C14_p20.
DR InterPro; IPR015917; Pept_C14A.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR48169:SF3; CASP8 AND FADD-LIKE APOPTOSIS REGULATOR A-RELATED; 1.
DR PANTHER; PTHR48169; DED DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF16095; COR; 1.
DR Pfam; PF00656; Peptidase_C14; 1.
DR SMART; SM00115; CASc; 1.
DR SUPFAM; SSF52129; Caspase-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS50207; CASPASE_P10; 1.
DR PROSITE; PS50208; CASPASE_P20; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000007879}.
FT DOMAIN 87..174
FT /note="Caspase family p20"
FT /evidence="ECO:0000259|PROSITE:PS50208"
FT DOMAIN 184..269
FT /note="Caspase family p10"
FT /evidence="ECO:0000259|PROSITE:PS50207"
SQ SEQUENCE 1602 AA; 181209 MW; 2FDFB68593BFD117 CRC64;
MDHVEPHSVE EQAKEKLLKE KVVEKGLDLP SHVAVYEEFT YVDNHTDIYK MNTVPRGYCL
IINMKKGREE ENQADVESLR SLFEGTLKFT FDVYEDLTKA QIDELMLKVQ GADHTQLCCF
VMFILAHGIH DRNESACFMT FDDMHYKVST IEREIENIPG LVGKPKLLFF HMCQQKISDH
GGTSDFLISF AGINSPVAWR GRNGSPFIQS LCDVFSNHYT TKEVGQLMAM VAERVAATSV
QIAPKTGMKN VKQHPVHIST LRKSFYFGKP PHYDTYPLNR TSIDPPPTVS DSTTIEPSNY
TGKMQKWLKE GEVELEITRI NMHGAPGAGK TCSLHLLLNE PPPSSTDSTP IACRAVQATQ
ISIDDKNKKW ERVGIINLLN QLASHFKEAL TSTDDVPNHS DELSLEEPTS IKKSTGMEVI
KEISNALEAG KLEKLSTNWV YFIDSGSQLA YRELLPLFTR AAALNIITID LTKGLDEKCK
FQYRIDQHMS SIDTDQKYSN RDIIQSTISS EAMLNPIEIP YVSRMPKHPQ YLILGTRKEL
VTEAKLQEMN EILTSSFNLD LKNVIQNAPQ ESIIFPVDTL LPAGSKEREK ASVDLCTAIS
NCAGAMTVML PIRLFAFEIA LQMEAEKKNR SFLTKKEVIE IGKSLRLDDE SDINEALRYL
HNVTILLYYP AVLPNLIFVD PKPILDVLSR LIAITSVGRA ELSLIANPPL SADELNSLKN
FGLLKTSIFE KIARQIFNKD FQPSHMIKLL RHLHIIARVK NREEEDYFFS CALSSYDKLD
DPPTKVQPLL IAWEINKSGT TTLAIPQGLF PLAIVYLLEQ DDVAFTPVGK GFYRCHNAMS
LRVDTEKKQY YIDIINRYTH IELRFHGPKK SCPLAFELVT KAIKKSSKKL NVDKNHILAF
KCPKNEHCYC IVQNEFFTRC TQCRQQCDVL QGDDGSYSCW FKDTQSFSSG KIEKWLKEGK
VELKVTRINM HGAPGAGKTC SLHLLLNEPP PPPSTVVACP AVQATRISID GENKWERVDI
EDLLNQLAST AVDDATDDRS ISAYSDKLSQ DEPSKNEPTD SEVVKKILHA YKTGKSKKLS
RNWVYFIDSG SQLAYRELLP LFTRAAALNI ITIDLTKGLD EKCKFQYRID QHMFSIDTDQ
KYSNRDIIQS TISSEAMLNP IEIPYVSHMP KHPQYLILGT RKELVTEAKL QEMNEILTSS
FNLDLKNVIQ NAPQESIIFP VDTLLPAGSK EREEASVDLC TAISNCAGAM TVMLPIRLFA
FEIALQMEAG KKNRSFLTKK EVIEIGKPLQ LDDESDIDKA LQYLHNVTIL LYYPAVLPNL
IFVDPKPILD VLSRLIAITS VGRAELSLIA NPPLSADELN SLKNFGLLKT SIFEKIARQI
FNKDFQPSHM IKLLRHLHII ARVKNREEED YFFSCALSSY DKLDDPPTKV QPLLIAWEIN
KSGTTTLAIP QGLFPLTIVH LLEQDDVAFT PAGEGFYRCH NAMSLRVDTE KKQYYIDIIN
RYTHIELRFH GPKESCPLAF ELVTKAIKKS SKKLNVGKNH ILAFKCPKNE HCYCIVKNEF
FTRCTQCPVQ CDVLQGDDGS YSCWFKDTQS FSSGQYTIKE NI
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