ID A0A1X7TW96_AMPQE Unreviewed; 962 AA.
AC A0A1X7TW96;
DT 05-JUL-2017, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2017, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=Caspase family p20 domain-containing protein {ECO:0000259|PROSITE:PS50208};
GN Name=109585611 {ECO:0000313|EnsemblMetazoa:Aqu2.1.19725_001};
OS Amphimedon queenslandica (Sponge).
OC Eukaryota; Metazoa; Porifera; Demospongiae; Heteroscleromorpha;
OC Haplosclerida; Niphatidae; Amphimedon.
OX NCBI_TaxID=400682 {ECO:0000313|EnsemblMetazoa:Aqu2.1.19725_001, ECO:0000313|Proteomes:UP000007879};
RN [1] {ECO:0000313|Proteomes:UP000007879}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20686567; DOI=10.1038/nature09201;
RA Srivastava M., Simakov O., Chapman J., Fahey B., Gauthier M.E., Mitros T.,
RA Richards G.S., Conaco C., Dacre M., Hellsten U., Larroux C., Putnam N.H.,
RA Stanke M., Adamska M., Darling A., Degnan S.M., Oakley T.H.,
RA Plachetzki D.C., Zhai Y., Adamski M., Calcino A., Cummins S.F.,
RA Goodstein D.M., Harris C., Jackson D.J., Leys S.P., Shu S., Woodcroft B.J.,
RA Vervoort M., Kosik K.S., Manning G., Degnan B.M., Rokhsar D.S.;
RT "The Amphimedon queenslandica genome and the evolution of animal
RT complexity.";
RL Nature 466:720-726(2010).
RN [2] {ECO:0000313|Proteomes:UP000007879}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Lucas S., Shapiro H., Lindquist E., Tice H., Dalin E., Glavina del Rio T.,
RA Bruce D., Barry K., Pitluck S., Srivastava M., Simakov O., Chapman J.,
RA Mitros T., Hellsten U., Putnam N.H., Fahey B., Gauthier M., Larroux C.,
RA Richards G.S., Stanke M., Adamska M., Darling A., Dacre M., Degnan S.M.,
RA Zhai Y., Adamski M., Calcino A., Cummins S.F., Goodstein D.M., Harris C.,
RA Shu S., Woodcroft B., Leys S.P., Manning G., Degnan B.M., Rokhsar D.S.;
RT "The genome of the haplosclerid demosponge Amphimedon queenslandica and the
RT evolution of animal complexity.";
RL Submitted (MAY-2010) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EnsemblMetazoa:Aqu2.1.19725_001}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (MAY-2017) to UniProtKB.
CC -!- SIMILARITY: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like
CC GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family.
CC IAN subfamily. {ECO:0000256|ARBA:ARBA00008535}.
CC -!- SIMILARITY: Belongs to the apolipoprotein L family.
CC {ECO:0000256|ARBA:ARBA00010090}.
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DR RefSeq; XP_019857299.1; XM_020001740.1.
DR AlphaFoldDB; A0A1X7TW96; -.
DR STRING; 400682.A0A1X7TW96; -.
DR EnsemblMetazoa; Aqu2.1.19725_001; Aqu2.1.19725_001; Aqu2.1.19725.
DR GeneID; 109585611; -.
DR KEGG; aqu:109585611; -.
DR InParanoid; A0A1X7TW96; -.
DR OrthoDB; 1949949at2759; -.
DR Proteomes; UP000007879; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:InterPro.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004197; F:cysteine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0005525; F:GTP binding; IEA:InterPro.
DR GO; GO:0008289; F:lipid binding; IEA:InterPro.
DR GO; GO:0006869; P:lipid transport; IEA:InterPro.
DR GO; GO:0042157; P:lipoprotein metabolic process; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR Gene3D; 3.40.50.1460; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR008405; ApoL.
DR InterPro; IPR029030; Caspase-like_dom_sf.
DR InterPro; IPR006703; G_AIG1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011600; Pept_C14_caspase.
DR InterPro; IPR001309; Pept_C14_p20.
DR PANTHER; PTHR14096; APOLIPOPROTEIN L; 1.
DR PANTHER; PTHR14096:SF28; PROTEIN CBG02395; 1.
DR Pfam; PF04548; AIG1; 1.
DR Pfam; PF05461; ApoL; 1.
DR Pfam; PF00656; Peptidase_C14; 1.
DR SUPFAM; SSF52129; Caspase-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS50208; CASPASE_P20; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000007879};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 556..579
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 585..608
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 299..396
FT /note="Caspase family p20"
FT /evidence="ECO:0000259|PROSITE:PS50208"
FT REGION 1..30
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 962 AA; 106521 MW; 66F5BF75D70E139C CRC64;
MADPRLLSDQ DDEEDTSIDG ERATGTHETV SDDITYLSKY DKSMSTMKHI LTSKGTSSDI
HLLVVGKTGQ GKSTFINSFI ELQKEIAEEG AEADMCTKSC HSYVHPELLP GVRVRVIDSP
GLQDIHNNEQ LYIEKIKAHC QEVSLVLYCM KMTNHRTSDD DKCALRKLHQ AFGPSFLKRV
VIVLTFANKE DCAQRDSRDD DDPEPPFTDT EAWAKLMKKR FVKRVQLRAA RINDFLKEHL
GIDDLVVQVV PAGYYKPTFS DHYPMKLPDR ENWLHDLITF AHSQIKEKHN FSLWNLNDKI
YLAFIIDNHG EVKVEKDGTK TINDDADKIK ETFNTLGFCT LYFNSLSSRS INTLLEVLHH
IDHSQLATFA FIFLCKGKTR HLYDCNNELI DADKIFGCLQ DEQSPFAQLP KIYYFHLAHD
KELKEKLQVS SIPSNNSILL ITSVIQKNSS VVLDTVTNNL KQGASIQKCF KEIQKECNTK
DNIKVSCMCI DSFTDKFVLP TPYKPFNLRA EKEYYKKQLE LYRSMWHPIR SETISIISEN
KDSLLDIVRN ERIARIVASS ASLVIGGGMV VTGLALIPFT LGASVGLSVA GGVVGATASL
GGVGAFIARK VLENKRLKSA QEHISLDQQL SISINEIAEK YNAAMVKCTE SALSSGGMVG
NVAAGGAQGI ANLGRVGMGI VVGLESAAEA GAIALRTGAR VAGAVLAGVS LAVTVPIDIG
FIAYHNTCIT IELQQHSIEG GLESTIEIAD LGYELIIPAL TEEQLTINLC TIFCGPFTLP
DGCTIVSAIY DIALPEELPP DFNATIKLEH CVDLKDDITA SKMCFATAAV DLEKKVFAFN
CIDGGTFSIG ETYASLKISK SCLICVLYKG SMRDTSVKYA GQCSYVKEYK NCWTMSILFT
KCLKAHLKYA QSESIGTIES HSFLFTDRND DQELSMGLHK FKNPMESNGW KISPLSLIPD
KV
//
