ID A0A1X7TXK4_AMPQE Unreviewed; 1171 AA.
AC A0A1X7TXK4;
DT 05-JUL-2017, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2017, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=EGF-like domain-containing protein {ECO:0000259|PROSITE:PS50026};
OS Amphimedon queenslandica (Sponge).
OC Eukaryota; Metazoa; Porifera; Demospongiae; Heteroscleromorpha;
OC Haplosclerida; Niphatidae; Amphimedon.
OX NCBI_TaxID=400682 {ECO:0000313|EnsemblMetazoa:Aqu2.1.20027_001, ECO:0000313|Proteomes:UP000007879};
RN [1] {ECO:0000313|Proteomes:UP000007879}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20686567; DOI=10.1038/nature09201;
RA Srivastava M., Simakov O., Chapman J., Fahey B., Gauthier M.E., Mitros T.,
RA Richards G.S., Conaco C., Dacre M., Hellsten U., Larroux C., Putnam N.H.,
RA Stanke M., Adamska M., Darling A., Degnan S.M., Oakley T.H.,
RA Plachetzki D.C., Zhai Y., Adamski M., Calcino A., Cummins S.F.,
RA Goodstein D.M., Harris C., Jackson D.J., Leys S.P., Shu S., Woodcroft B.J.,
RA Vervoort M., Kosik K.S., Manning G., Degnan B.M., Rokhsar D.S.;
RT "The Amphimedon queenslandica genome and the evolution of animal
RT complexity.";
RL Nature 466:720-726(2010).
RN [2] {ECO:0000313|Proteomes:UP000007879}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Lucas S., Shapiro H., Lindquist E., Tice H., Dalin E., Glavina del Rio T.,
RA Bruce D., Barry K., Pitluck S., Srivastava M., Simakov O., Chapman J.,
RA Mitros T., Hellsten U., Putnam N.H., Fahey B., Gauthier M., Larroux C.,
RA Richards G.S., Stanke M., Adamska M., Darling A., Dacre M., Degnan S.M.,
RA Zhai Y., Adamski M., Calcino A., Cummins S.F., Goodstein D.M., Harris C.,
RA Shu S., Woodcroft B., Leys S.P., Manning G., Degnan B.M., Rokhsar D.S.;
RT "The genome of the haplosclerid demosponge Amphimedon queenslandica and the
RT evolution of animal complexity.";
RL Submitted (MAY-2010) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EnsemblMetazoa:Aqu2.1.20027_001}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (MAY-2017) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR AlphaFoldDB; A0A1X7TXK4; -.
DR STRING; 400682.A0A1X7TXK4; -.
DR EnsemblMetazoa; Aqu2.1.20027_001; Aqu2.1.20027_001; Aqu2.1.20027.
DR eggNOG; KOG1217; Eukaryota.
DR InParanoid; A0A1X7TXK4; -.
DR Proteomes; UP000007879; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0007154; P:cell communication; IEA:InterPro.
DR CDD; cd00054; EGF_CA; 4.
DR Gene3D; 2.10.25.140; -; 2.
DR Gene3D; 2.10.25.10; Laminin; 5.
DR InterPro; IPR001774; DSL.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR PANTHER; PTHR24044; NOTCH LIGAND FAMILY MEMBER; 1.
DR PANTHER; PTHR24044:SF498; PROTEIN EYES SHUT HOMOLOG-RELATED; 1.
DR Pfam; PF01414; DSL; 2.
DR Pfam; PF00008; EGF; 2.
DR PRINTS; PR00010; EGFBLOOD.
DR SMART; SM00051; DSL; 2.
DR SMART; SM00181; EGF; 8.
DR SMART; SM00179; EGF_CA; 5.
DR SUPFAM; SSF57196; EGF/Laminin; 4.
DR PROSITE; PS00010; ASX_HYDROXYL; 1.
DR PROSITE; PS00022; EGF_1; 6.
DR PROSITE; PS01186; EGF_2; 4.
DR PROSITE; PS50026; EGF_3; 5.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000007879};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..16
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 17..1171
FT /note="EGF-like domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5013276528"
FT TRANSMEM 308..335
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 487..506
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 987..1011
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 776..809
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 811..850
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 852..889
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 891..927
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 929..965
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT REGION 1081..1105
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1148..1171
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 799..808
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 821..838
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 840..849
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 879..888
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 917..926
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 955..964
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 1171 AA; 127940 MW; 3B5CEF2921DC2B7A CRC64;
MMIILLLMCL IEPLKASVFT LKLEFHNYDN PNGWNSVKVC CDRGPLSGTC YSPCETKFSI
CLRNGNTSQI DKSCPSSSDI MTSGIVPGDS LTFGASIGSL LNPLTFYLDS LHFSGVQVYI
KIEDDDLGIY DDDLNQDITD LIDELFVQIP SNGRNAAYRM MYGIHGVASI NASYQLACTD
DNYYGNDCSV YCKPQNDESA GHYSCNQTTG EKICLSGYVD PSSNCTCTVN NPNCFNTATT
TISKLASSIS ITTIVPTYSM LASTTQISPV ATVDEPTHSS MLLTASATTE QISMTQTPTV
KSDGLGSVII AAVITAFVLI GVITIFVSVI ILLLWKRKQK PLPDIDKTGT IYDSTAKESS
ISGNNNLENP MYIDQPLDIS SSHQHTYEFM DGPTIPGNPV SIGRINEPDP MDYQLLYETP
VDGAFNKETV LIKSLPDPQA LDYEEPRDST LNAGTVSCPL YETPVNPNND HGEGLELQPL
QPGSATVMYT LDAVAFFLLG LLLHQVNGDY ELLLRFRRYS NPTDRDNNDN CCDNILICVS
HCDTLFRSLC LRNRDSNSEP QCIPGTVYDP GTVGDYNGPD NSITFGESVG SISNPIIYER
PGSIPESGFQ LYMEVFDYDS RNDNDYIDSI VLNIPAQPTT ERQSTVVGED GKISLELSYS
LSCSQNYYGS DCSQQCIPRN DNTNGHYTCN TTTGGIICRE GWQNITTNCT DVACHLVCQS
PGGNCSSDGT CECNSNWFGD QCQNPNCTEG CHPEGGFCNM PNECLCHSNW NGTLCDELLC
NVNCSSRGGE CLEPESCSCL PGYTGNECEI DLLPCENQMP CLNGGNCTQN DTTGEYSCSC
SVGYTGFTCD TDIDECATKP CQNNGTCINE EAGSYSCICP TGWTGELCMK AIDYCESNPC
TNNGTCTSAR AGHYCDCTSQ YKGLNCELFV NACILYPCLN NGTCVDLVTN YTCLCPEGFT
GNNCEKRVIE SSVSSAPSTD TTQVTAIIGS VIGAIMLIII VIISLFIVIL LKKRRQGLKN
RSKSSVVNYN LVKGSNDQLS LDHNNNYDIT DHKISKLNSV EDSTDYARLR LPEAEYQEVN
EIQSAADDND KEDGEPMYNN PAYYGTRKTT DECEAEYQEI KEIPSADCSQ DEPVYKTVIN
PVYGDVLEEE QPSSDKYVPN PLYGGVKEQG Q
//
