ID A0A1X7TY54_AMPQE Unreviewed; 2303 AA.
AC A0A1X7TY54;
DT 05-JUL-2017, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2017, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE RecName: Full=Protein-tyrosine-phosphatase {ECO:0008006|Google:ProtNLM};
OS Amphimedon queenslandica (Sponge).
OC Eukaryota; Metazoa; Porifera; Demospongiae; Heteroscleromorpha;
OC Haplosclerida; Niphatidae; Amphimedon.
OX NCBI_TaxID=400682 {ECO:0000313|EnsemblMetazoa:Aqu2.1.20040_001, ECO:0000313|Proteomes:UP000007879};
RN [1] {ECO:0000313|Proteomes:UP000007879}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20686567; DOI=10.1038/nature09201;
RA Srivastava M., Simakov O., Chapman J., Fahey B., Gauthier M.E., Mitros T.,
RA Richards G.S., Conaco C., Dacre M., Hellsten U., Larroux C., Putnam N.H.,
RA Stanke M., Adamska M., Darling A., Degnan S.M., Oakley T.H.,
RA Plachetzki D.C., Zhai Y., Adamski M., Calcino A., Cummins S.F.,
RA Goodstein D.M., Harris C., Jackson D.J., Leys S.P., Shu S., Woodcroft B.J.,
RA Vervoort M., Kosik K.S., Manning G., Degnan B.M., Rokhsar D.S.;
RT "The Amphimedon queenslandica genome and the evolution of animal
RT complexity.";
RL Nature 466:720-726(2010).
RN [2] {ECO:0000313|Proteomes:UP000007879}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Lucas S., Shapiro H., Lindquist E., Tice H., Dalin E., Glavina del Rio T.,
RA Bruce D., Barry K., Pitluck S., Srivastava M., Simakov O., Chapman J.,
RA Mitros T., Hellsten U., Putnam N.H., Fahey B., Gauthier M., Larroux C.,
RA Richards G.S., Stanke M., Adamska M., Darling A., Dacre M., Degnan S.M.,
RA Zhai Y., Adamski M., Calcino A., Cummins S.F., Goodstein D.M., Harris C.,
RA Shu S., Woodcroft B., Leys S.P., Manning G., Degnan B.M., Rokhsar D.S.;
RT "The genome of the haplosclerid demosponge Amphimedon queenslandica and the
RT evolution of animal complexity.";
RL Submitted (MAY-2010) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EnsemblMetazoa:Aqu2.1.20040_001}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (MAY-2017) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00302}.
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DR EnsemblMetazoa; Aqu2.1.20040_001; Aqu2.1.20040_001; Aqu2.1.20040.
DR InParanoid; A0A1X7TY54; -.
DR Proteomes; UP000007879; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0007160; P:cell-matrix adhesion; IEA:InterPro.
DR CDD; cd00033; CCP; 9.
DR CDD; cd00063; FN3; 12.
DR Gene3D; 2.10.70.10; Complement Module, domain 1; 9.
DR Gene3D; 2.60.40.10; Immunoglobulins; 12.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003886; NIDO_dom.
DR InterPro; IPR035976; Sushi/SCR/CCP_sf.
DR InterPro; IPR000436; Sushi_SCR_CCP_dom.
DR PANTHER; PTHR19325; COMPLEMENT COMPONENT-RELATED SUSHI DOMAIN-CONTAINING; 1.
DR PANTHER; PTHR19325:SF567; LOCOMOTION-RELATED PROTEIN HIKARU GENKI; 1.
DR Pfam; PF00041; fn3; 9.
DR Pfam; PF06119; NIDO; 1.
DR Pfam; PF00084; Sushi; 9.
DR SMART; SM00032; CCP; 9.
DR SMART; SM00060; FN3; 14.
DR SMART; SM00539; NIDO; 1.
DR SUPFAM; SSF57535; Complement control module/SCR domain; 9.
DR SUPFAM; SSF49265; Fibronectin type III; 8.
DR PROSITE; PS50853; FN3; 12.
DR PROSITE; PS51220; NIDO; 1.
DR PROSITE; PS50923; SUSHI; 9.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00302}; Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000007879};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Sushi {ECO:0000256|PROSITE-ProRule:PRU00302};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 2184..2212
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 97..252
FT /note="NIDO"
FT /evidence="ECO:0000259|PROSITE:PS51220"
FT DOMAIN 261..319
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 320..378
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 379..437
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 438..501
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 502..565
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 566..624
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 625..683
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 684..747
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 748..810
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 910..1000
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1005..1094
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1099..1191
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1195..1285
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1290..1381
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1386..1474
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1479..1566
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1568..1660
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1661..1761
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1849..1970
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1975..2067
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 2071..2167
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DISULFID 290..317
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 349..376
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 408..435
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 472..499
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 536..563
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 595..622
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 654..681
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 718..745
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
SQ SEQUENCE 2303 AA; 249694 MW; 9F63749D20DA013F CRC64;
MLTDLFKKCF NADYKESLPP WLNVLNQLTN WITQDLSNVP NSSATKAELA AKLNKWSSTK
DGKIKALINN NGLLSFNEAV SAFTSQPFPL PQTLIAPFWA DVDTRSGAGT VYYRETSTSA
IVNKVARDVL LAFPGQPSFT ATSVVIVTWY RVGYYSRQSD KLNTFQCVLA TDGSRSYVIF
LYLDNGINWV TGDASGGNDG FGGTEAYVGF NSGGQNSTYF AVQGSRTPAV VNIETTSNVD
VAGLWIFQVN EANIVTSTVT VNCSELIVDS EELSVFYNST TYNSTATYSC ESGFNLVGAT
KRTCLNSGNW SGDPPSCEIV NCSELIVDSE ELSVSYNSTT YNSTATYSCE SGFNLVGATK
RTCLNSGNWS GDPPSCEIVN CSELIVDSEE LSVSYNSTTY NSTATYSCES GFNLVGATKR
TCLNSGNWSG DPPSCEIVNC SELIVETNAF GGLSVSYSSN SRSYNSTATY SCEDGYSLTG
IFIRTCLSSG NWSGDPPSCE IVNCSELMVE SNAFGGLSVS FSSNSRSYNS TATYSCEDGY
SLIGVSVRTC LSSGNWSGDP PFCKIVNCSK LIVDSEELSV FYNSTSYNST ATYSCVSGFN
LAGVAERTCL SSGNWSGDPP SCEIVNCSEL IVDSEELSVS YNSTSYNSTA TYSCESGFNL
VGVAEKTCLS SGNWSGDPPY CQIVNCSELI VESNAFGGLS VSYSSNSRSY NSTAIYSCEK
GFSLTGVSIR TCLSSGNWSG DPPFCKIVNC SELMVESNAY GGLSVSLSSS NFNSTATYSC
TYEGYVLVGN GVRTCQANGN WSEAEPNCEI TAINLNGASN ESSIIISWDL PCQLRNMTKD
RMVNNYTVMV TDIATGEYFI IIATKIPVVL SNLSLNTNYS IRIAVFTNKL GPFSDYPLYI
STHLTAPTHP AFDLNINSSS PTSFMISWTP PMLDYLNGPN ITYVILVTSA NSSFNYTSNT
NYAIIAGLQP FTTYWCRVAV RNNAGMGPYS LSIEIKTLED VPSSAPVNVI FIFINARTLL
VQWGLIPLSN RNGIIMYYEI LVIVGEKTYI YKTSERNITI ENLQPSYTYN ISVAAFTNGR
GPFSEPISIT MPDDVPSGRP QSLSLASAGA TSLSISWNPP DEEDRNGNIN EYIVNVTNTD
TLVTTQFTTA NNDFSIVDLN PDTTYSLSVA ARNANGTGPF TQSLLTKTGQ SAPSQPRHLK
ATAIGSSSIL LAWESPSNPN GDITAYYINI TDESTSTVVM QETSNITYVI ITDLSPNNTY
RCHVAAATTY IGQVSEYVFV NTEEDVPTAA PLSVLPIAID STMISISWSP PNINTTNGVI
RYYKVSIINI ATGSEQTLTT ANSHLTILML TPFTAYSVRV AAFTIGTGPY SRPINVTTAE
DIPSDAPKNF DATTNGSNFL ILKWFPPNTP NGIIKYYQIT LLDQTNSTVF HFNTTEFEFT
INNLLYFTKY TCYVSAFTVA AGPAAMLTIM TQESAPSSPP TSIMLKSVNY TSINVSWSPP
AVPNGLIHMY IIRISNGLLV IDYNSTEEYM LITGLMPNQN YSVSLAAVTI DIGPFSTNLV
ITLQEKVATD PPTGLCNELN GSNLTLHWLP PPDGSVDGII SGYRINCTGE NGHFISKTVS
MTRVSVDLEK GTYYTCMVCI LTSAGCGPAA VNYINTYSGF PVGPPQSLSV NTTDLSILID
WEAPSDPLNI ITSYAITYQL LDTPVSLAVP RPVATVSGIT DTMYLLELVL SASSYNITVY
ANTSNGTGIE SEPIAITTEK SGTLLNFMCS AASSTDINCS WENLSNDDYQ LHYSILPSFN
YYTNNEGTIN EGRIHDLKPY VGYVISLQLS NTNLVNTVVL TQPEIPTASV EDISFNVLSP
DSFTLSWKLP PKNEWKGIIE NFIIKAVPIK SIGENAEINI TSLRPKDVEI TVAPRANNPD
PSLAMEPFAR EEVIVSNLEP DFEYSLTISI DNAAGRGPSS SPLNISMPEA APSGRPLNLV
LSNVQQTSFT ATWLPPNLIE RNGRIISYMV QVTRFNLLQT RSFETQDTRI FLQGYYPYEH
IMIKVAARTS VGLGPYSSVL AFNTNENVPS VPVSFSGTVI GSDQVILSWD MPQTTDGVIS
QYQVIYSGYT IASNIPAIGP IQINVPVNHL QLFRLRNGLV YHFSVRAENT AGYGPNATTI
IVLDDNIGEL VGATRDVSGV DGRMIAVSVL AGLFGLLLCL FLSIGLICCL CARMRQKKRE
NNKMHINGNT EIKEISFANI KDASQNEAGS RQTNMSSSDN QHVYDEPNIK LTTSTVAASN
DYDTVTSPTV KRISPEDTRE VNL
//
