ID   A0A1X7TZ01_AMPQE        Unreviewed;      1188 AA.
AC   A0A1X7TZ01;
DT   05-JUL-2017, integrated into UniProtKB/TrEMBL.
DT   05-JUL-2017, sequence version 1.
DT   27-MAR-2024, entry version 22.
DE   RecName: Full=AIG1-type G domain-containing protein {ECO:0000259|Pfam:PF04548};
OS   Amphimedon queenslandica (Sponge).
OC   Eukaryota; Metazoa; Porifera; Demospongiae; Heteroscleromorpha;
OC   Haplosclerida; Niphatidae; Amphimedon.
OX   NCBI_TaxID=400682 {ECO:0000313|EnsemblMetazoa:Aqu2.1.20340_001, ECO:0000313|Proteomes:UP000007879};
RN   [1] {ECO:0000313|Proteomes:UP000007879}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=20686567; DOI=10.1038/nature09201;
RA   Srivastava M., Simakov O., Chapman J., Fahey B., Gauthier M.E., Mitros T.,
RA   Richards G.S., Conaco C., Dacre M., Hellsten U., Larroux C., Putnam N.H.,
RA   Stanke M., Adamska M., Darling A., Degnan S.M., Oakley T.H.,
RA   Plachetzki D.C., Zhai Y., Adamski M., Calcino A., Cummins S.F.,
RA   Goodstein D.M., Harris C., Jackson D.J., Leys S.P., Shu S., Woodcroft B.J.,
RA   Vervoort M., Kosik K.S., Manning G., Degnan B.M., Rokhsar D.S.;
RT   "The Amphimedon queenslandica genome and the evolution of animal
RT   complexity.";
RL   Nature 466:720-726(2010).
RN   [2] {ECO:0000313|Proteomes:UP000007879}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Lucas S., Shapiro H., Lindquist E., Tice H., Dalin E., Glavina del Rio T.,
RA   Bruce D., Barry K., Pitluck S., Srivastava M., Simakov O., Chapman J.,
RA   Mitros T., Hellsten U., Putnam N.H., Fahey B., Gauthier M., Larroux C.,
RA   Richards G.S., Stanke M., Adamska M., Darling A., Dacre M., Degnan S.M.,
RA   Zhai Y., Adamski M., Calcino A., Cummins S.F., Goodstein D.M., Harris C.,
RA   Shu S., Woodcroft B., Leys S.P., Manning G., Degnan B.M., Rokhsar D.S.;
RT   "The genome of the haplosclerid demosponge Amphimedon queenslandica and the
RT   evolution of animal complexity.";
RL   Submitted (MAY-2010) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|EnsemblMetazoa:Aqu2.1.20340_001}
RP   IDENTIFICATION.
RG   EnsemblMetazoa;
RL   Submitted (MAY-2017) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like
CC       GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family.
CC       IAN subfamily. {ECO:0000256|ARBA:ARBA00008535}.
CC   -!- SIMILARITY: Belongs to the apolipoprotein L family.
CC       {ECO:0000256|ARBA:ARBA00010090}.
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DR   AlphaFoldDB; A0A1X7TZ01; -.
DR   EnsemblMetazoa; Aqu2.1.20340_001; Aqu2.1.20340_001; Aqu2.1.20340.
DR   InParanoid; A0A1X7TZ01; -.
DR   Proteomes; UP000007879; Unassembled WGS sequence.
DR   GO; GO:0005576; C:extracellular region; IEA:InterPro.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0008289; F:lipid binding; IEA:InterPro.
DR   GO; GO:0006869; P:lipid transport; IEA:InterPro.
DR   GO; GO:0042157; P:lipoprotein metabolic process; IEA:InterPro.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   InterPro; IPR008405; ApoL.
DR   InterPro; IPR006703; G_AIG1.
DR   InterPro; IPR045058; GIMA/IAN/Toc.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR10903:SF135; GTP-BINDING PROTEIN A; 1.
DR   PANTHER; PTHR10903; GTPASE, IMAP FAMILY MEMBER-RELATED; 1.
DR   Pfam; PF04548; AIG1; 1.
DR   Pfam; PF05461; ApoL; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE   3: Inferred from homology;
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007879}.
FT   DOMAIN          27..154
FT                   /note="AIG1-type G"
FT                   /evidence="ECO:0000259|Pfam:PF04548"
SQ   SEQUENCE   1188 AA;  133743 MW;  5DFEE1CE080CA8D9 CRC64;
     MASLKGIMKT FQKIFNEEKI PAVNIHLLVI GRTGHGKSTL INSIIEQCKA ISPEGARRNS
     CTTKSRSFTY HDVIPGINVT LIDSPGLQHA NGDEQKYLQE LKSECKEVSL VLYCTNMKEF
     RDTKDDKVAI RKLHQVFGSN FWKRVVFVLT FANEENCGRR DDRDTAVDPP KLPPPGDKEW
     ENLKRKRFIN RVSLFKEEIN DFMKECLDIH EHFEAVPAGC YQKNEDSKDH DPMKLPDRED
     WLYDVLKLSI EQIKIKHKFS MLRLDNKINF AIIIDNRGSI EVEDNSIKIL SQEARSLKEA
     LEATSTISTF SPTIKSFVNN ISYEKVEKCF ENMKKELGSS CNVVKQSLQD NLFIKQAASE
     MNEKQVHDLL CSMWRPIRCS TINELMKIKD EVVSVVLKER ATKITTTTSG LAIGGSMMMV
     GLILTPFTFG ASLGLTAAGA GVSIATTISG TAASAISTAM ENKKLKLAQE HIMFDTQLSL
     AINEFKMKVK KNSDKKVALA VAVGTHLFSN FGHIGVRVVT AGVEAGINAG STALRAGGAV
     AGGASLAVTL PIDIGFIAHY GYQLWQLKKD KSGKSDKNEV IQWLFGQVEE LLKRTSDVID
     TTRHQIKDEQ RLVHSNLSVG YSIEVPLTTK DESSIIVRTI FSGPFKLPEG YTLVSAIYDV
     TIEKELKEPV TIYLQHCVRV NNQLLQKKMH FARATINFEA KMFDFEVVED GTFLTGENRG
     SLKIMPKKDC LNYILCVLFE GTSQDTSMKY AAQYSYTRHY KNFWSLSIIF EKDLSAHQKF
     TQAGYYNQFA FVRTDGSDDL ALKNISDAIE KNGWKISPSD ENLLTITKGE IDEAHTKKLN
     KKLNKKFNFP SINLNVYVHN ENDVVDELVH PLKFQGTNLE ICVKRQKEKS KFMALDVSEY
     PLQIEQDTEF VNPRCGYQIH LPTCRDNGTC VTVRTIISGP FVLPSGYSLA SAAYEITMPQ
     LAQPVIIEVE HCVNVNDDDS VKQNMCFATA TIDMQTQKFE FIPFEGASPS ITNESATITV
     NDSCLVCILY QESKNIETTA KKYSAQWTYK KTGHNSWNLN IRFTKYLSAH DHRRHIKSEH
     QQSFVFKKPT NDYPLHLELD SILSADRTAE MAGWAITACD DTPTPVAITK EEIDGIELAN
     KMANFPSINL QVCVKDKETA IDELDKTFMI NGTDLEIVIN RKKEVEVV
//