ID A0A1X7U0S5_AMPQE Unreviewed; 766 AA.
AC A0A1X7U0S5;
DT 05-JUL-2017, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2017, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE RecName: Full=SH3 domain-containing protein {ECO:0000259|PROSITE:PS50002};
OS Amphimedon queenslandica (Sponge).
OC Eukaryota; Metazoa; Porifera; Demospongiae; Heteroscleromorpha;
OC Haplosclerida; Niphatidae; Amphimedon.
OX NCBI_TaxID=400682 {ECO:0000313|EnsemblMetazoa:Aqu2.1.20973_001, ECO:0000313|Proteomes:UP000007879};
RN [1] {ECO:0000313|Proteomes:UP000007879}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20686567; DOI=10.1038/nature09201;
RA Srivastava M., Simakov O., Chapman J., Fahey B., Gauthier M.E., Mitros T.,
RA Richards G.S., Conaco C., Dacre M., Hellsten U., Larroux C., Putnam N.H.,
RA Stanke M., Adamska M., Darling A., Degnan S.M., Oakley T.H.,
RA Plachetzki D.C., Zhai Y., Adamski M., Calcino A., Cummins S.F.,
RA Goodstein D.M., Harris C., Jackson D.J., Leys S.P., Shu S., Woodcroft B.J.,
RA Vervoort M., Kosik K.S., Manning G., Degnan B.M., Rokhsar D.S.;
RT "The Amphimedon queenslandica genome and the evolution of animal
RT complexity.";
RL Nature 466:720-726(2010).
RN [2] {ECO:0000313|Proteomes:UP000007879}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Lucas S., Shapiro H., Lindquist E., Tice H., Dalin E., Glavina del Rio T.,
RA Bruce D., Barry K., Pitluck S., Srivastava M., Simakov O., Chapman J.,
RA Mitros T., Hellsten U., Putnam N.H., Fahey B., Gauthier M., Larroux C.,
RA Richards G.S., Stanke M., Adamska M., Darling A., Dacre M., Degnan S.M.,
RA Zhai Y., Adamski M., Calcino A., Cummins S.F., Goodstein D.M., Harris C.,
RA Shu S., Woodcroft B., Leys S.P., Manning G., Degnan B.M., Rokhsar D.S.;
RT "The genome of the haplosclerid demosponge Amphimedon queenslandica and the
RT evolution of animal complexity.";
RL Submitted (MAY-2010) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EnsemblMetazoa:Aqu2.1.20973_001}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (MAY-2017) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; A0A1X7U0S5; -.
DR STRING; 400682.A0A1X7U0S5; -.
DR EnsemblMetazoa; Aqu2.1.20973_001; Aqu2.1.20973_001; Aqu2.1.20973.
DR InParanoid; A0A1X7U0S5; -.
DR Proteomes; UP000007879; Unassembled WGS sequence.
DR GO; GO:0005096; F:GTPase activator activity; IEA:InterPro.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR027038; RanGap.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR24113:SF12; F-BOX DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR24113; RAN GTPASE-ACTIVATING PROTEIN 1; 1.
DR Pfam; PF00018; SH3_1; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF52047; RNI-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000007879};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 444..505
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 386..411
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 766 AA; 86567 MW; 0DAC099CED92B057 CRC64;
MLQGYIGRLA QVVLTEESVD LLHTEGLISK DTLAEVKSCG FSLVGDPMLL ILSAVAEDHN
KLCTLTSILM KSKEAVSLAS DIIMKYGNSF PSAVAVMPPC QQTNTSSFSA SQQLQDSSSE
IQVNTNTDAT AHGVVEVIVH PGYKAEFDRM GDLRGTLIDD IAPLIEKSIP SLTHLKTYLG
RCRPELKPRL KDANSFDDIM EVIEDECSIT NVALLETIVN KYSIQDAGDM ILAYQAHLDE
FCENKLTMFC NHQLKKLSSS LLTCETIKFV LKWNPSEHSL SSIRALLWKT FKDNQVEVVV
IKEGNSINVT CYAPHYLMES LLVSARDNID VLKEMGLISL TIGYYTVYDE HAIDEEVKSL
MKKLEVIESE RDDLLEENAK LKSTKDTLGR EIDENNKSSM QSSVSGRKDS KKMTKAMQME
IDHLRSSLQC KTGKDQSTQY IDHQKGPVYV AIRDWEAKNI TQLSIKKGEK LGIKKERTDG
WWLAKSLDTD QEGYVYISDI EKDEESELST LETLELFHYA MTENVDIPKI KELKMRSNVE
RARLFWSLIK QDSVLLDQLR RKEREKPKAI RWYDDGVQLT SPSLIQCKEV ASLLTYKHTN
IKIIKSSPDV VSDLLPVLLQ NEKVEYLRIR DTQLTQDCIS SLCNLLANSK SLVDLHLINC
SIDDKAVADI TNILCTHNNT LLQLFFFKNP HITSASAQSL SELISNNSTL TALEVRRTSI
SSAGILLILQ SLTMNKNIKL ILDIKHKDTC TEYQDYNIMR DRVLFY
//
