ID A0A1X7U2C0_AMPQE Unreviewed; 1376 AA.
AC A0A1X7U2C0;
DT 05-JUL-2017, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2017, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=ATP-dependent DNA helicase {ECO:0000256|RuleBase:RU363044};
DE EC=3.6.4.12 {ECO:0000256|RuleBase:RU363044};
OS Amphimedon queenslandica (Sponge).
OC Eukaryota; Metazoa; Porifera; Demospongiae; Heteroscleromorpha;
OC Haplosclerida; Niphatidae; Amphimedon.
OX NCBI_TaxID=400682 {ECO:0000313|EnsemblMetazoa:Aqu2.1.21908_001, ECO:0000313|Proteomes:UP000007879};
RN [1] {ECO:0000313|Proteomes:UP000007879}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20686567; DOI=10.1038/nature09201;
RA Srivastava M., Simakov O., Chapman J., Fahey B., Gauthier M.E., Mitros T.,
RA Richards G.S., Conaco C., Dacre M., Hellsten U., Larroux C., Putnam N.H.,
RA Stanke M., Adamska M., Darling A., Degnan S.M., Oakley T.H.,
RA Plachetzki D.C., Zhai Y., Adamski M., Calcino A., Cummins S.F.,
RA Goodstein D.M., Harris C., Jackson D.J., Leys S.P., Shu S., Woodcroft B.J.,
RA Vervoort M., Kosik K.S., Manning G., Degnan B.M., Rokhsar D.S.;
RT "The Amphimedon queenslandica genome and the evolution of animal
RT complexity.";
RL Nature 466:720-726(2010).
RN [2] {ECO:0000313|Proteomes:UP000007879}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Lucas S., Shapiro H., Lindquist E., Tice H., Dalin E., Glavina del Rio T.,
RA Bruce D., Barry K., Pitluck S., Srivastava M., Simakov O., Chapman J.,
RA Mitros T., Hellsten U., Putnam N.H., Fahey B., Gauthier M., Larroux C.,
RA Richards G.S., Stanke M., Adamska M., Darling A., Dacre M., Degnan S.M.,
RA Zhai Y., Adamski M., Calcino A., Cummins S.F., Goodstein D.M., Harris C.,
RA Shu S., Woodcroft B., Leys S.P., Manning G., Degnan B.M., Rokhsar D.S.;
RT "The genome of the haplosclerid demosponge Amphimedon queenslandica and the
RT evolution of animal complexity.";
RL Submitted (MAY-2010) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EnsemblMetazoa:Aqu2.1.21908_001}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (MAY-2017) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC Evidence={ECO:0000256|RuleBase:RU363044};
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|RuleBase:RU363044};
CC -!- SIMILARITY: Belongs to the helicase family.
CC {ECO:0000256|RuleBase:RU363044}.
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DR EnsemblMetazoa; Aqu2.1.21908_001; Aqu2.1.21908_001; Aqu2.1.21908.
DR InParanoid; A0A1X7U2C0; -.
DR Proteomes; UP000007879; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR GO; GO:0000723; P:telomere maintenance; IEA:InterPro.
DR CDD; cd18809; SF1_C_RecD; 1.
DR Gene3D; 3.60.10.10; Endonuclease/exonuclease/phosphatase; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR010285; DNA_helicase_pif1-like.
DR InterPro; IPR036691; Endo/exonu/phosph_ase_sf.
DR InterPro; IPR025476; Helitron_helicase-like.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR049163; Pif1-like_2B_dom.
DR PANTHER; PTHR47642; ATP-DEPENDENT DNA HELICASE; 1.
DR PANTHER; PTHR47642:SF2; PHD-TYPE DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF14214; Helitron_like_N; 1.
DR Pfam; PF05970; PIF1; 1.
DR Pfam; PF21530; Pif1_2B_dom; 1.
DR SUPFAM; SSF56219; DNase I-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|RuleBase:RU363044};
KW DNA damage {ECO:0000256|RuleBase:RU363044};
KW DNA recombination {ECO:0000256|RuleBase:RU363044};
KW DNA repair {ECO:0000256|RuleBase:RU363044};
KW Helicase {ECO:0000256|RuleBase:RU363044};
KW Hydrolase {ECO:0000256|RuleBase:RU363044};
KW Nucleotide-binding {ECO:0000256|RuleBase:RU363044};
KW Reference proteome {ECO:0000313|Proteomes:UP000007879}.
FT DOMAIN 33..165
FT /note="Helitron helicase-like"
FT /evidence="ECO:0000259|Pfam:PF14214"
FT DOMAIN 979..1008
FT /note="DNA helicase Pif1-like 2B"
FT /evidence="ECO:0000259|Pfam:PF21530"
SQ SEQUENCE 1376 AA; 156387 MW; EEE533589870AE45 CRC64;
MNCYIWRQRP QDNSLTARQV RDPRSLAQYV RKDKAYRFLK NVRGSPPYFQ RTLYELLAMV
RQFGTPTWFF TVSAADLKWP DMIKVIAQQY NVHYTDDEVS QLSFEERSSW IRRNPVAAVR
HFHYRLNCLF NDFLLTDAKP LGEIVDYSWR IEFQQRGSPH AHCVLWVKGA PKFGVDSNND
VCTFINKYIS CEMPTEDGHL KDLVSLLQRH RHSSYCKRKG NCRFQFPRLP SESTLIACPN
SDITVLNNVT KCLDKVKKAL KNSETNLNMK DLLNLAGVTS EDYKQAISMT KSGHVIVLKR
QPKDCLVNNY NREVLLAWEA NIDIQFILNP YACVMYVASY MMKSEKAMGE LLKHVANEER
TAELTEQLRK VGAAFLSHRD LGAQEAACRI LSLPMKKHSR EQEFVNTGPK DERVALIKNG
RGRQHLDDDD NDVFCKTLCE RYVHRPQSLT PMCLAEFAAN YRPKYGSSND ATVNDDGDDV
LPSEDVTCNP APVTTITLTD NYGSMAKRRR EAAIRFHKWS KDTDSNNWYR AKIMLYYHWR
NEESDLLGGY DTYEEHYRQV VSEITTNEKK YTVEEVEHID FHDDPPQHVW DSIAPTTEHN
RGCDHDEGTT NLRDLEREDI AEMSHNDDQC SSTHTSAILS RFDIAVNSDI IPSEEYRSLF
RGLNKKQRKI VLFHRKWCKE TAIALKNGKT VTPYHLFVSG PGGVGKSHII KIIKSDTIKL
LRLSGIFEPD DVMVLLTAPT GVAAFNIGGM TLHSALLLSR SKSSGYQSLS HDRANTLRMR
LGKLKLLIID EISMVGCNML LDIHKRLNEI LVQPDGIFFG NVSVLAVGDL YQLPPVMQPP
LFRTISNSEI ASLFGCGSLW RELFHIVELT DIMRQRGDSR FIELLCRVRT AECNDSDIDM
LKSRIITDDF PDYPKNSLHV YRHNKDVDRH NLDMLNKLAS ESEQFTILAR DSTAGQTDHL
NLSNLSDRKS DTGNLHGILK LAIGSRVMLT SNVSVSDGLV NGARGEVVYI VCNYNNDVSR
VLVKFDDPNV GQQAIQCSQY KNIYSNAVPL KKIEVKFLAQ GRHGSEVTRY QFPLTLAWAT
TIHKVQGLTM DTIVIDMNNS SAFSPGQAYV AFSRVKSFSG LFIKNFNEHA IKKSDEVHEE
MTRLKENMLI ISPVHSNLDN FLLKIGLLNV RSVSNKIGDL VNDVNLKDAS VIGLCETWLV
PSQPSPCINN GHIVMRCDRN TNDHGGVLLS VMQSMSPGNV IRINRNGIEI ISSCIKCNDC
VIQIVVLYRS PCVSIQELFS AIIDLFNSID LSLPTIIMGD FNENFSEDIE PLVASSRQLK
TLMSDHNFDQ KILSSTTDTG SLIDHLYYNN IYFKIHTVVF DCYYSDHDVV CAILTL
//
