ID A0A1X7U6K1_AMPQE Unreviewed; 1030 AA.
AC A0A1X7U6K1;
DT 05-JUL-2017, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2017, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=Death domain-containing protein {ECO:0000259|PROSITE:PS50017};
OS Amphimedon queenslandica (Sponge).
OC Eukaryota; Metazoa; Porifera; Demospongiae; Heteroscleromorpha;
OC Haplosclerida; Niphatidae; Amphimedon.
OX NCBI_TaxID=400682 {ECO:0000313|EnsemblMetazoa:Aqu2.1.23298_001, ECO:0000313|Proteomes:UP000007879};
RN [1] {ECO:0000313|Proteomes:UP000007879}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20686567; DOI=10.1038/nature09201;
RA Srivastava M., Simakov O., Chapman J., Fahey B., Gauthier M.E., Mitros T.,
RA Richards G.S., Conaco C., Dacre M., Hellsten U., Larroux C., Putnam N.H.,
RA Stanke M., Adamska M., Darling A., Degnan S.M., Oakley T.H.,
RA Plachetzki D.C., Zhai Y., Adamski M., Calcino A., Cummins S.F.,
RA Goodstein D.M., Harris C., Jackson D.J., Leys S.P., Shu S., Woodcroft B.J.,
RA Vervoort M., Kosik K.S., Manning G., Degnan B.M., Rokhsar D.S.;
RT "The Amphimedon queenslandica genome and the evolution of animal
RT complexity.";
RL Nature 466:720-726(2010).
RN [2] {ECO:0000313|Proteomes:UP000007879}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Lucas S., Shapiro H., Lindquist E., Tice H., Dalin E., Glavina del Rio T.,
RA Bruce D., Barry K., Pitluck S., Srivastava M., Simakov O., Chapman J.,
RA Mitros T., Hellsten U., Putnam N.H., Fahey B., Gauthier M., Larroux C.,
RA Richards G.S., Stanke M., Adamska M., Darling A., Dacre M., Degnan S.M.,
RA Zhai Y., Adamski M., Calcino A., Cummins S.F., Goodstein D.M., Harris C.,
RA Shu S., Woodcroft B., Leys S.P., Manning G., Degnan B.M., Rokhsar D.S.;
RT "The genome of the haplosclerid demosponge Amphimedon queenslandica and the
RT evolution of animal complexity.";
RL Submitted (MAY-2010) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EnsemblMetazoa:Aqu2.1.23298_001}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (MAY-2017) to UniProtKB.
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DR AlphaFoldDB; A0A1X7U6K1; -.
DR EnsemblMetazoa; Aqu2.1.23298_001; Aqu2.1.23298_001; Aqu2.1.23298.
DR InParanoid; A0A1X7U6K1; -.
DR Proteomes; UP000007879; Unassembled WGS sequence.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd01670; Death; 2.
DR CDD; cd00882; Ras_like_GTPase; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR000488; Death_domain.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR24193:SF121; ANK_REP_REGION DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR24193; ANKYRIN REPEAT PROTEIN; 1.
DR Pfam; PF12796; Ank_2; 2.
DR Pfam; PF00531; Death; 1.
DR SMART; SM00248; ANK; 4.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF47986; DEATH domain; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 3.
DR PROSITE; PS50088; ANK_REPEAT; 3.
DR PROSITE; PS50017; DEATH_DOMAIN; 2.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|ARBA:ARBA00023043, ECO:0000256|PROSITE-
KW ProRule:PRU00023}; Reference proteome {ECO:0000313|Proteomes:UP000007879}.
FT DOMAIN 27..102
FT /note="Death"
FT /evidence="ECO:0000259|PROSITE:PS50017"
FT REPEAT 373..406
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 407..428
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 475..499
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 952..1029
FT /note="Death"
FT /evidence="ECO:0000259|PROSITE:PS50017"
FT REGION 195..219
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1030 AA; 115587 MW; 4E8353B433DBA5DC CRC64;
MANLVLGVKD LSDVHDLLKK CNFPETKWYV FGLKLGLQKN TLEIIEKNHP HDVSRCLIEC
LSEWLHRADD VDSKGGVTID SLINALKSME ANAVASAVRL ITPSAPTAAT NKQGYPPLSP
IALKDIPDDR PKVSELIKFY ELLKKKELEF LPLLDADTIE KIRNAVNDYE GMSLLIRAID
ELLNEMRATR IIKSPSQKRV ETLSSPELEP QQPSLTTQPP VTTPICKLNH SPQIQPCQSQ
LMHVDPHSFS TTIQLSSKEE VAETIESLDC QFAGLVLEIR KRFDELVLNK KLKPETQLLK
LFKDANHEDA VRLLPYIKNL KQLQDEVTIK ISPFDTYQVE ATLLHMASWN GWLDVTGDLI
TKYGCDQQER DTKGNTCLHY AAMGNHVSVM EYLIIKYSSD PTVTNENGDT ILHKAAYYGS
LDVIKFLIIN HRCNPKSTNL KKGETLLHCA AEHVDILKYL INDEGSCNPM ATTFDGKTPL
HYAANFGCSA SVEFLLSTGK CDPLAKDKYG KTPLQLAKER RQRGGTDTVP IFKQFGDIKS
SHPIDSYVNV LLVGNFGAGK STLVHVINDT ATGSIVLGSF RNVGGVVPSC FAGIIPYKLQ
HRTLGSIILH DFAGHSEYYS SHSDIIENLL QGFGGVFLIV VNILEKEAVK QLHQWLTIVR
NEAQKALNQC HIIVIVSHVD EISNSVERRR RKEEMQEIIV RERCDSVFLD CRKLGGSGVN
SFFKKLSSAC ESIRSTSERN SSLYCYMMYG LLEERKENIL TLSDVMSAGK DSDDYVLPDK
REDVLDVLHS LHSTGLISVL KSEDKVWVVV NKGILLTEVN GILFVPMTFK EHIDIASNTG
IVSVSGLTKL FPKYDPDMLI YFLKNMGLCQ EINPSFLRMT NLHQLAVDEE EEGETERRGE
RLLFLPCLLS NFDILMINDE AQETQTDKLL DIKDLATVLQ ELTSNQQFDY TDWYQLGLYL
GLYEHTLRAI EEESRGRLKK CLLECIASWL KGEDGVAETR GGGSSWTSLV AALDAMGERE
VANNIRIKYL
//
