ID A0A1X7U7R8_AMPQE Unreviewed; 435 AA.
AC A0A1X7U7R8;
DT 05-JUL-2017, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2017, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=SRCR domain-containing protein {ECO:0000259|PROSITE:PS50287};
GN Name=105313838 {ECO:0000313|EnsemblMetazoa:Aqu2.1.23698_001};
OS Amphimedon queenslandica (Sponge).
OC Eukaryota; Metazoa; Porifera; Demospongiae; Heteroscleromorpha;
OC Haplosclerida; Niphatidae; Amphimedon.
OX NCBI_TaxID=400682 {ECO:0000313|EnsemblMetazoa:Aqu2.1.23698_001, ECO:0000313|Proteomes:UP000007879};
RN [1] {ECO:0000313|Proteomes:UP000007879}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20686567; DOI=10.1038/nature09201;
RA Srivastava M., Simakov O., Chapman J., Fahey B., Gauthier M.E., Mitros T.,
RA Richards G.S., Conaco C., Dacre M., Hellsten U., Larroux C., Putnam N.H.,
RA Stanke M., Adamska M., Darling A., Degnan S.M., Oakley T.H.,
RA Plachetzki D.C., Zhai Y., Adamski M., Calcino A., Cummins S.F.,
RA Goodstein D.M., Harris C., Jackson D.J., Leys S.P., Shu S., Woodcroft B.J.,
RA Vervoort M., Kosik K.S., Manning G., Degnan B.M., Rokhsar D.S.;
RT "The Amphimedon queenslandica genome and the evolution of animal
RT complexity.";
RL Nature 466:720-726(2010).
RN [2] {ECO:0000313|Proteomes:UP000007879}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Lucas S., Shapiro H., Lindquist E., Tice H., Dalin E., Glavina del Rio T.,
RA Bruce D., Barry K., Pitluck S., Srivastava M., Simakov O., Chapman J.,
RA Mitros T., Hellsten U., Putnam N.H., Fahey B., Gauthier M., Larroux C.,
RA Richards G.S., Stanke M., Adamska M., Darling A., Dacre M., Degnan S.M.,
RA Zhai Y., Adamski M., Calcino A., Cummins S.F., Goodstein D.M., Harris C.,
RA Shu S., Woodcroft B., Leys S.P., Manning G., Degnan B.M., Rokhsar D.S.;
RT "The genome of the haplosclerid demosponge Amphimedon queenslandica and the
RT evolution of animal complexity.";
RL Submitted (MAY-2010) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EnsemblMetazoa:Aqu2.1.23698_001}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (MAY-2017) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00196}.
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DR RefSeq; XP_011405882.1; XM_011407580.2.
DR AlphaFoldDB; A0A1X7U7R8; -.
DR EnsemblMetazoa; Aqu2.1.23698_001; Aqu2.1.23698_001; Aqu2.1.23698.
DR GeneID; 105313838; -.
DR eggNOG; ENOG502SBU1; Eukaryota.
DR InParanoid; A0A1X7U7R8; -.
DR OMA; ACHTTRI; -.
DR Proteomes; UP000007879; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR Gene3D; 3.10.250.10; SRCR-like domain; 2.
DR InterPro; IPR001190; SRCR.
DR InterPro; IPR017448; SRCR-like_dom.
DR InterPro; IPR036772; SRCR-like_dom_sf.
DR PANTHER; PTHR48071:SF18; LCCL_LECTIN ADHESIVE-LIKE PROTEIN 1; 1.
DR PANTHER; PTHR48071; SRCR DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00530; SRCR; 2.
DR PRINTS; PR00258; SPERACTRCPTR.
DR SMART; SM00202; SR; 2.
DR SUPFAM; SSF56487; SRCR-like; 2.
DR PROSITE; PS50287; SRCR_2; 2.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00196}; Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000007879};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..435
FT /note="SRCR domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5010883190"
FT TRANSMEM 284..317
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 25..144
FT /note="SRCR"
FT /evidence="ECO:0000259|PROSITE:PS50287"
FT DOMAIN 157..257
FT /note="SRCR"
FT /evidence="ECO:0000259|PROSITE:PS50287"
FT REGION 339..435
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 339..353
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 354..369
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 386..404
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 182..246
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 195..256
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 225..235
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
SQ SEQUENCE 435 AA; 46162 MW; 700C6556A600342F CRC64;
MGLLSVLLLL IGLIYTARCQ NRGTVRLVRS GTFSSSYSAG IVQIYYFTSS SSTNRWGNIC
YDSSFGSTEA SVICNQLGYN GASSYGRDGS TSSYGTDSSA TIIDDVSCSN SNYLTLQQCT
LSTSISTLSS CSLRTSYDAY VACHTTRIWN NPYSGQIRLQ GSTYSSYGRL EVYCNGQWGT
VCDDTFGFTD ARVACRQLGY SDYNSYSGNL AGSSSQPIWL DRVYCSSSDS CLAYCESCPS
SEYHDCTHSE DVALGCEFDT SRTDSTNTLS TCRYADSSAN IGGIIGGVIA AFVICCVLII
SIPICICCCL GVGIGAAARG GRSGRATVVT AGTTTATSAT VTTTNTSNLT APPPPAYEQQ
PPPPAAYPAA YPAAGYDAEK APYPPQQGYP AQPGYPPQEG YPPQGYAYPP QGYEAQPGYP
PQQGYNYPPP AYPAQ
//
