ID A0A1X7U9W6_AMPQE Unreviewed; 742 AA.
AC A0A1X7U9W6;
DT 05-JUL-2017, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2017, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=Polycystin cation channel PKD1/PKD2 domain-containing protein {ECO:0000259|Pfam:PF08016};
GN Name=100636588 {ECO:0000313|EnsemblMetazoa:Aqu2.1.24550_001};
OS Amphimedon queenslandica (Sponge).
OC Eukaryota; Metazoa; Porifera; Demospongiae; Heteroscleromorpha;
OC Haplosclerida; Niphatidae; Amphimedon.
OX NCBI_TaxID=400682 {ECO:0000313|EnsemblMetazoa:Aqu2.1.24550_001, ECO:0000313|Proteomes:UP000007879};
RN [1] {ECO:0000313|Proteomes:UP000007879}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20686567; DOI=10.1038/nature09201;
RA Srivastava M., Simakov O., Chapman J., Fahey B., Gauthier M.E., Mitros T.,
RA Richards G.S., Conaco C., Dacre M., Hellsten U., Larroux C., Putnam N.H.,
RA Stanke M., Adamska M., Darling A., Degnan S.M., Oakley T.H.,
RA Plachetzki D.C., Zhai Y., Adamski M., Calcino A., Cummins S.F.,
RA Goodstein D.M., Harris C., Jackson D.J., Leys S.P., Shu S., Woodcroft B.J.,
RA Vervoort M., Kosik K.S., Manning G., Degnan B.M., Rokhsar D.S.;
RT "The Amphimedon queenslandica genome and the evolution of animal
RT complexity.";
RL Nature 466:720-726(2010).
RN [2] {ECO:0000313|Proteomes:UP000007879}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Lucas S., Shapiro H., Lindquist E., Tice H., Dalin E., Glavina del Rio T.,
RA Bruce D., Barry K., Pitluck S., Srivastava M., Simakov O., Chapman J.,
RA Mitros T., Hellsten U., Putnam N.H., Fahey B., Gauthier M., Larroux C.,
RA Richards G.S., Stanke M., Adamska M., Darling A., Dacre M., Degnan S.M.,
RA Zhai Y., Adamski M., Calcino A., Cummins S.F., Goodstein D.M., Harris C.,
RA Shu S., Woodcroft B., Leys S.P., Manning G., Degnan B.M., Rokhsar D.S.;
RT "The genome of the haplosclerid demosponge Amphimedon queenslandica and the
RT evolution of animal complexity.";
RL Submitted (MAY-2010) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EnsemblMetazoa:Aqu2.1.24550_001}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (MAY-2017) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR RefSeq; XP_019855367.1; XM_019999808.1.
DR AlphaFoldDB; A0A1X7U9W6; -.
DR EnsemblMetazoa; Aqu2.1.24550_001; Aqu2.1.24550_001; Aqu2.1.24550.
DR GeneID; 100636588; -.
DR eggNOG; KOG3733; Eukaryota.
DR InParanoid; A0A1X7U9W6; -.
DR OMA; ISCCINR; -.
DR OrthoDB; 2877219at2759; -.
DR Proteomes; UP000007879; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005261; F:monoatomic cation channel activity; IEA:InterPro.
DR InterPro; IPR039031; Mucolipin.
DR InterPro; IPR013122; PKD1_2_channel.
DR PANTHER; PTHR12127; MUCOLIPIN; 1.
DR PANTHER; PTHR12127:SF7; SD02261P; 1.
DR Pfam; PF08016; PKD_channel; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000007879};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 387..412
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 442..468
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 480..500
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 520..542
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 588..609
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 474..615
FT /note="Polycystin cation channel PKD1/PKD2"
FT /evidence="ECO:0000259|Pfam:PF08016"
FT REGION 22..66
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 22..40
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 51..66
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 742 AA; 84835 MW; C2101725049950FB CRC64;
MSRPRVSEKA SSKTQSLHLA LNDMSRNYSS SRTSGGPVGR SINNDPGVGG EERSSSKRDS
VDPIDSLTIR SRKRSREDFS FKSCFTSFCQ KLYNFTIASC QYSFCYFCYS KVRRGSYQNM
ENFENEPDGS TEGIRAEIEA MKSELKFHFM NPFQKWKYDK RRRFPWKLLV HMIVITLVTI
QLCVCAEERR ELKTFVFNNR DTFNDLFIIK PIANDRHDPL NYYGKASAGT IRKIEDLWGQ
INHTIITYYS IKTIAIGPYQ YGSEDDSNTL PPPLILDLIL FDYKNSTTTI SISKDADIHE
LLYDNGVSRS VTNIDSMTFK FNLSSFYKDQ NFYLCATFHI EIELKNNVID GTMPVYLRAE
SEFDPCEDDD GDQKRLNYRG STQHDSVLLA VLGSLVLLFT IISTAQCIRS LVTSARFTKR
VKNFFLKHFN YKLSLSEYLP LYNVWFMGVI CSNVLVVVGT IMFLFTAFIN EGALFELSDV
SSIIFGMGVF FQWLGLLRFL SYFDKYNILL ITLRLAIPSV IRFMVCGFIF YVAFLLLGWL
VLGPYHPKFA DPSVTSECLY SLINGDDMFN TYIQMDSSSF SAFIFSKIYL YVFISLFIYV
VLSVFISLIS DTYETLHEVW TVRSRGFLQD FANDCLIETT DEGQTSQTNI DNDFEVLTGS
NRGSTDNSPL LHRPVTTYLG RSGQFRTTTP TVHLHPAANS PLGQTRVTAS YSAINNNNNN
SSPEMERAPL LYPRLTGSRN HV
//