GenomeNet

Database: UniProt
Entry: A0A1X7U9X5_AMPQE
LinkDB: A0A1X7U9X5_AMPQE
Original site: A0A1X7U9X5_AMPQE 
ID   A0A1X7U9X5_AMPQE        Unreviewed;      4726 AA.
AC   A0A1X7U9X5;
DT   05-JUL-2017, integrated into UniProtKB/TrEMBL.
DT   05-JUL-2017, sequence version 1.
DT   28-FEB-2018, entry version 6.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|EnsemblMetazoa:Aqu2.1.24560_001};
OS   Amphimedon queenslandica (Sponge).
OC   Eukaryota; Metazoa; Porifera; Demospongiae; Heteroscleromorpha;
OC   Haplosclerida; Niphatidae; Amphimedon.
OX   NCBI_TaxID=400682 {ECO:0000313|EnsemblMetazoa:Aqu2.1.24560_001, ECO:0000313|Proteomes:UP000007879};
RN   [1] {ECO:0000313|EnsemblMetazoa:Aqu2.1.24560_001, ECO:0000313|Proteomes:UP000007879}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Lucas S., Shapiro H., Lindquist E., Tice H., Dalin E.,
RA   Glavina del Rio T., Bruce D., Barry K., Pitluck S., Srivastava M.,
RA   Simakov O., Chapman J., Mitros T., Hellsten U., Putnam N.H., Fahey B.,
RA   Gauthier M., Larroux C., Richards G.S., Stanke M., Adamska M.,
RA   Darling A., Dacre M., Degnan S.M., Zhai Y., Adamski M., Calcino A.,
RA   Cummins S.F., Goodstein D.M., Harris C., Shu S., Woodcroft B.,
RA   Leys S.P., Manning G., Degnan B.M., Rokhsar D.S.;
RT   "The genome of the haplosclerid demosponge Amphimedon queenslandica
RT   and the evolution of animal complexity.";
RL   Submitted (MAY-2010) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EnsemblMetazoa:Aqu2.1.24560_001}
RP   IDENTIFICATION.
RG   EnsemblMetazoa;
RL   Submitted (MAY-2017) to UniProtKB.
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DR   EnsemblMetazoa; Aqu2.1.24560_001; Aqu2.1.24560_001; Aqu2.1.24560.
DR   Proteomes; UP000007879; Unassembled WGS sequence.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR   CDD; cd00051; EFh; 1.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 5.
DR   Pfam; PF13499; EF-hand_7; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 1.
DR   Pfam; PF00622; SPRY; 2.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00054; EFh; 2.
DR   SMART; SM00472; MIR; 2.
DR   SMART; SM00449; SPRY; 2.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF49899; SSF49899; 1.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50188; B302_SPRY; 1.
DR   PROSITE; PS00018; EF_HAND_1; 2.
DR   PROSITE; PS50222; EF_HAND_2; 2.
DR   PROSITE; PS50919; MIR; 3.
PE   4: Predicted;
KW   Calcium {ECO:0000256|PROSITE-ProRule:PRU00448};
KW   Complete proteome {ECO:0000313|Proteomes:UP000007879};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007879};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4223   4244       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4307   4327       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4339   4359       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4523   4545       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4604   4623       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      146    198       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      221    282       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      288    377       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN     1022   1223       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     3992   4019       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   DOMAIN     4021   4054       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   CA_BIND    3997   4008       {ECO:0000256|PROSITE-ProRule:PRU00448}.
FT   CA_BIND    4032   4043       {ECO:0000256|PROSITE-ProRule:PRU00448}.
SQ   SEQUENCE   4726 AA;  538075 MW;  830558734C2890B2 CRC64;
     GDSVGFAMST TTGRIVKHYL STGFGTQYCT VLLEPSDDQE PTVIWRHIFE VFDAISPHAI
     HGWNEKESQA KGCRVLLYGQ AILLRMASGY KYLRCLPHHA GRVGKYKMND FHSHYLIGSS
     SPNQKAQVDE YCWFVIRPAT NQRSEGEKVK AGDDIHLVNL GTGRYLSLPH ERPVAYDTTS
     TSLSIDFDDD TFTDIPVATF SPWTWIIDII RSHAANAGLL NGYVNAGDPI QLKVAHRDDE
     LMSIPLSSLE DPLAVNDAKR MVYFEDKSVK LELRSLWLVM LSGVSYGRAF IEYGQPFRLR
     HMVSGMYLGV DQNRQLVLVD GKNAQRDPCC FCFVKKGSPV PPINYKREGM GTPTIKMGET
     EVSLYHISSK LWVTLELMGP SLRRLRTGFS GPPRALLSDE PHGFSFTTLK AMHIALSTVV
     CNELETVMLA FSEAMRRIQG QSTNDRSIRS IKESAEEKTL AKLNESLVFL IPPNKEIMDI
     HTYQDLLMKL RNRQTRLLNH GTANMVFALL RKTVSHYGHD VTSNGLQIQQ ALCRILANVV
     KGNRLACRRF ANRESIQNMF ELINNPSLLH PMLEVMDCLL EESPEVLLSL TEENVRHLFT
     LLYCHGRDHK VMSLLGRLPV CQGVAMREKQ LQICRLLQDS HQLLLHTSLM PKLYSMYANV
     FLSSKDNVEA TKLYFEVQWT RSEAAGTKPY IRIGCVQYLN FLPYPKSKGS MATQGGIGDD
     GSSVSFDGQH ILMNSEKYGL QSIPLAKGQF KKQSPEDEQD VTVYGCCLDL EKGTLMFTIN
     GQLFPLLVNF HLNENTIAVP AVSFTGGVEN ARLCFGSGYG DLYFAPPIGY QPLSCFIEQK
     ANGKKEKICL YPFVCVGDSN ERILNGPIQY NDSVWFRPSV PDLTNVTIPS RLHQLINDLA
     VESHDTWAVS QIVLGHSSPN LTAFPHLPKD VQLQRIQEGR NLIATLISLG CRISATDTHP
     ISHQDLPDDP YLQLNGFKPC PLELLDDLPV SLQPLITQLS EIEHNKWSKE RMSKGWKYGV
     TTRPQVMQDC CLVPYQCLPL DIKKKYELVV KKSLLVLSSL GYTVQSPPID YLKRDLGHTL
     VSFRTFRGQF LGYCTGSGKW FFKVKLLKGR MSRIGWAIPR YSSSSLLGSD SFSYAIDGHN
     VVKWHDGLSE NFGHILEEGD EITCLLDLDE GTMSFACNDK LLLSLTHQSG IAFSDLPRNE
     LYVPAVSVFM GEQVQMILTT MKDQETSSSR NITAGYRSIE NDIKVRIPLW YSHVSHQFKD
     ITPSHSYLKI TKTKEDELTV NSNEAKLTCL RLNMGVEMTL DKRRDKDDPV DEREGGSEES
     QNDDDREKYS FSVTLPAGEA PSAVYFGWAR EDFLYDPNDF HTHSDDLILN ANATIELISD
     SDSPFGDAMF EEFEETGVKD VFSRGDTMKD GVKRRMNTNS TTSTKKRRSQ LESIEEWPIE
     DDDDDESSSF RVTGKEHVLR KHQCAAYLLK MSALLKVDES VYLATDTQVD CVINPSTGLM
     KFSCLSYSKN AVFELRVRAP GRLFPILITR PKYLKIGSFS FGPAKGCQPL VKALLGKYYK
     DTFPNLLPSM KLMSISDSCW YQMDDRSSLY PTESCLYIPN MPSYDITHLC LPQEGNVMRL
     TELIESPSLY SFHVETLRTY RACCMHDNSK AAEMVNKIVS WKELVHSIKS SYWSYQLVAE
     SFNLVNTLYL EHKVLEHQLI RQDSIFASDC VSCSTSSPSS SYNAGRRHSS NSLLNRTVTI
     CCNTEKEWLS SCHYYQLSVL KDITFQVLDS VILADVMTCR MLSAEYNNCL FLPLLKAVDC
     FLVLGMLQDS ERLLSLLHPS LAPSGHKANF YILTMPTKDP QIQSVLCDIL DHLCDAQLQG
     RLDHIIEFAS GFVEELQEDQ RKRVMESDPN QFLSPLVIQE INTPTEKQLN TLLSFSSDSC
     LTSESLKDSL QSFHADLSLH CNGIPSSINQ TADLSSFQKL AKLVSLVTVR SSSSESENSP
     DTSSLHKLRD VIISTVLRWS RSTISDIKMA EKTYKLLYRQ FNESEMLRKA IQRTYIVEQY
     SEFSSGEISK FRSALGKMRK MLVVGFGEEE EPVFQELLQE LSTCDLFQRH PDLLRFAGVH
     SLVINVMKSY FSFSETLSSA FPSSFGTESS SGFVGMTQTL KLAVSDEGFA DIVEDCCKFL
     CSFAQTSHQN QIALSEHLQY LLDECLIFSD QVASNSTNPL DVAIATISNN LQLVMTLSNE
     GILHKVVQLM HKMMKYEDEA SSTANNTISS PIHKMSVLYD AMPMEWLPTG AEKCLKFLQA
     AVYVNGETIE ENAAAIIRLL IQQPDCLGPC YINQHLSLVK MFSSCFSQIN SLKTTKKPKR
     LTRASSRLTD TIVRLASDTE LPQVSQSDYR QRSLHRSSTL NLFYKQLSAL TSELTVSFYT
     LLVRVLGLCA PSIDTRKNFS CTRKVKYSTE HILPFLRTLI GLEDLRDLLS LPMNVMPPTH
     KEALMVFLDR VYSKSDKRLV LDLIREAFLP DIKATIHQAK KTKYDAFVYL RYISCHVLPY
     LEHQSSTLDL LSEFPLLLNL IHEVYQLIAL ATDSHRRMIE QFLITMTKTL PPPSILKLLP
     MIMDDIKDLS KPSFTVALKI LTVHHSHHSR YYTTGSVIGQ YKLCRPSHKE RVYIALLFSL
     VLKSLCHAKE ASIAGIINQC LESLACAILP EILVPPIAEL KALSVETATL SPSHTSTPSS
     TPSPPLEDEG SSLTRIVNNL SAYIDQIEFS SEYHSHVFEF AKFCHENWVY EMQQVNGWSY
     DHVSNPDTYH DDRLRPFEYI NDELGDRVVD EVKQVLQVLL FYGCVFNEGN GGGQLESIPL
     KPKLLCLFGA NKKKVLRTIT DDPDTWYSYE PLVVDLDQIE LPLHALIIVS SANTIMNHIV
     LPTVEERGDT QSDLGTYDPI RLMYYEKTNR RSYGLIEDFL KFMKVKGLTV ANPFAAIPGS
     MQYMLSKTID SKPFSLQLFE CFLTVLRYEC CCTAGYTCRC QSHKQEIFPA FCSYLNTHAS
     YFNPNIEGEE RRLTFATLDE KIPLIKLFFE VHSYIGSHLD SFLISTSKTA TVAPGEATTS
     KGEISWNTEL QAIKERNQKL LNRLLSLSMS LIKVLDVSQF GVLEETKSFF SYVISTLESL
     EKSLNKINSN QSNQFDKKLF LYVTHCLAPS LTALFRRCED IVMSPVNGVV KSRFSDVFSC
     VFSLVCNEIT IFIESDTLSI IGQCLSEVCL ADSKFQCSRF ENRLAMLLLK RGALLKLSTQ
     KISFVALVIA PVLTNRSIRE AKNGSNVEVD KVLKLVLRIL SEYQGDKETT WMKDLSCSVC
     HLASYCSIPV YKTHLIPLLM KMSDRGSRLW QEEQLVTSSL SIKESDLLIK QKQFEKRLKL
     YGQDLVSVLL FLVFFTEKNP SLVADLRNKT LFHHTALILN HYFTSQKFSS ILNSCSTSFI
     QNVRGRKTER WNILISFAMT IIRHLPSSAF QFLQQLNPLF DQPGKSSADI DQAILDLIKC
     LAESDSRTGI DVKLNGRNHD EEKREILQIL MTYKTAPFVI QSFARVQRLM RQIVTPSLIV
     RERWRDAMSR KKREGIVACL KAVPFHRLKK HRAMNLFLQE YSSSWLSQCH SFNMENLCEE
     IIDKEEYYQE KQARSSVISL INDRYVDPLE QLFSLLGMQA STGQWYGNST DLYDSFANAV
     IETFQTMIDD AEELEGNSIY DNFESIRYQV VAKQGLLIKK KVPEMILAIL TSSNGKLCPL
     VHITLKLGIV QLEGGNASAQ ERIMEKVKSL GSEFWTSIAG LISHFGTLDW NIYEKSQIVV
     QDQNNIGERV FPTSDQVLAL FRFLQLLCEG HNEGFQNLLR TQGSNAMSTN IVIATVDYLL
     KLQDSIRDFY WYHAKQDSLE LPARETFLLS FKVAKQLFRT LTEYIQGPCV GNQEALAKSR
     FWDAMGGFLH VFVALQQKLF CYTSHMELLL ELLGLQEEYF ILLLAMLEGT TKVSAVGEHM
     LNMLHESDQF LKELITFYNI FIKLKDVSSS TAFKEYDLNK DGLISYQEFE QAMRAQQFYT
     KSEIQYLMKL ADTNKDGLLD YQEFTERFYQ PTHKLGFHLC ALIRQLSDTM PGNPKLKEIE
     KNCLKLSEYF EDNIGCIEMM GKSGNVERVY FHIKTSHALQ WNDPAIKESR HNFLHSFDWT
     SQKEKLGEFM NFCEDTIFQM TYNDRMFNVE QEEREKRTDN LRKSQFPETA QYNTRSMLSS
     AQTKLLSLGI TDPGHIYLKA HSLLSFIWFT LILGVIVAPL THLVHYTRVF YDFCFYGGQG
     PLKYSSSNPS FLKQYFMQYF RPAQFYLPRT MYASKSLRGH LAHSYYMIKY CLVLTTILIN
     FLILISIQAD KNEDSISLYL SIHLHFVLSC LLMVSFWHLK VPLIIFQKEK NIARRLEKHK
     GSVTSDHFSF FDRLALRSPS FPRRFWDRQI KERVFDKSPS ENRTKLASAL GIVNKSRFDE
     VSRYEQLSNA IASLIDVRYQ AWRIVMICFS DMTFRYHLGY CLLSLAGIKY NVFFFSLHLL
     ELTLQSKTLV NVLRSLKINM KQLLMTLVVT SVVIYIYSAV AFSFFRKFYV QQVESGYVRD
     NCGNMLTCFL FHIDHGLRSG GGIADVILSA FEDQVYLGRL VFDLTYFFVV IVILLAVFQG
     LIIDAFGELR KKDDLVLEEL KNKCFICGLS LADFKNPHEF DTHINRHHSL KDYMFFLLHL
     ISKPDTEFTG QESMIWSLYL EQTWDFFPAG TCFQTQERRA SDALAN
//
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