ID A0A1X7UA33_AMPQE Unreviewed; 1350 AA.
AC A0A1X7UA33;
DT 05-JUL-2017, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2017, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE RecName: Full=Deleted in malignant brain tumors 1 protein {ECO:0008006|Google:ProtNLM};
OS Amphimedon queenslandica (Sponge).
OC Eukaryota; Metazoa; Porifera; Demospongiae; Heteroscleromorpha;
OC Haplosclerida; Niphatidae; Amphimedon.
OX NCBI_TaxID=400682 {ECO:0000313|EnsemblMetazoa:Aqu2.1.24518_001, ECO:0000313|Proteomes:UP000007879};
RN [1] {ECO:0000313|Proteomes:UP000007879}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20686567; DOI=10.1038/nature09201;
RA Srivastava M., Simakov O., Chapman J., Fahey B., Gauthier M.E., Mitros T.,
RA Richards G.S., Conaco C., Dacre M., Hellsten U., Larroux C., Putnam N.H.,
RA Stanke M., Adamska M., Darling A., Degnan S.M., Oakley T.H.,
RA Plachetzki D.C., Zhai Y., Adamski M., Calcino A., Cummins S.F.,
RA Goodstein D.M., Harris C., Jackson D.J., Leys S.P., Shu S., Woodcroft B.J.,
RA Vervoort M., Kosik K.S., Manning G., Degnan B.M., Rokhsar D.S.;
RT "The Amphimedon queenslandica genome and the evolution of animal
RT complexity.";
RL Nature 466:720-726(2010).
RN [2] {ECO:0000313|Proteomes:UP000007879}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Lucas S., Shapiro H., Lindquist E., Tice H., Dalin E., Glavina del Rio T.,
RA Bruce D., Barry K., Pitluck S., Srivastava M., Simakov O., Chapman J.,
RA Mitros T., Hellsten U., Putnam N.H., Fahey B., Gauthier M., Larroux C.,
RA Richards G.S., Stanke M., Adamska M., Darling A., Dacre M., Degnan S.M.,
RA Zhai Y., Adamski M., Calcino A., Cummins S.F., Goodstein D.M., Harris C.,
RA Shu S., Woodcroft B., Leys S.P., Manning G., Degnan B.M., Rokhsar D.S.;
RT "The genome of the haplosclerid demosponge Amphimedon queenslandica and the
RT evolution of animal complexity.";
RL Submitted (MAY-2010) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EnsemblMetazoa:Aqu2.1.24518_001}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (MAY-2017) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00196}.
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DR EnsemblMetazoa; Aqu2.1.24518_001; Aqu2.1.24518_001; Aqu2.1.24518.
DR InParanoid; A0A1X7UA33; -.
DR Proteomes; UP000007879; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:InterPro.
DR CDD; cd00063; FN3; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR Gene3D; 3.10.250.10; SRCR-like domain; 9.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR001212; Somatomedin_B_dom.
DR InterPro; IPR001190; SRCR.
DR InterPro; IPR017448; SRCR-like_dom.
DR InterPro; IPR036772; SRCR-like_dom_sf.
DR PANTHER; PTHR48071; SRCR DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR48071:SF22; SRCR DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00530; SRCR; 9.
DR PRINTS; PR00258; SPERACTRCPTR.
DR SMART; SM00060; FN3; 2.
DR SMART; SM00202; SR; 9.
DR SUPFAM; SSF49265; Fibronectin type III; 1.
DR SUPFAM; SSF56487; SRCR-like; 9.
DR PROSITE; PS50853; FN3; 1.
DR PROSITE; PS50958; SMB_2; 2.
DR PROSITE; PS00420; SRCR_1; 3.
DR PROSITE; PS50287; SRCR_2; 9.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00196}; Reference proteome {ECO:0000313|Proteomes:UP000007879};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..1350
FT /note="Deleted in malignant brain tumors 1 protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5012598099"
FT DOMAIN 28..130
FT /note="SRCR"
FT /evidence="ECO:0000259|PROSITE:PS50287"
FT DOMAIN 140..182
FT /note="SMB"
FT /evidence="ECO:0000259|PROSITE:PS50958"
FT DOMAIN 203..302
FT /note="SRCR"
FT /evidence="ECO:0000259|PROSITE:PS50287"
FT DOMAIN 310..419
FT /note="SRCR"
FT /evidence="ECO:0000259|PROSITE:PS50287"
FT DOMAIN 429..476
FT /note="SMB"
FT /evidence="ECO:0000259|PROSITE:PS50958"
FT DOMAIN 477..580
FT /note="SRCR"
FT /evidence="ECO:0000259|PROSITE:PS50287"
FT DOMAIN 590..690
FT /note="SRCR"
FT /evidence="ECO:0000259|PROSITE:PS50287"
FT DOMAIN 693..797
FT /note="SRCR"
FT /evidence="ECO:0000259|PROSITE:PS50287"
FT DOMAIN 805..907
FT /note="SRCR"
FT /evidence="ECO:0000259|PROSITE:PS50287"
FT DOMAIN 915..1017
FT /note="SRCR"
FT /evidence="ECO:0000259|PROSITE:PS50287"
FT DOMAIN 1025..1125
FT /note="SRCR"
FT /evidence="ECO:0000259|PROSITE:PS50287"
FT DOMAIN 1144..1233
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DISULFID 55..119
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 101..111
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 274..284
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 386..396
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 547..557
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 662..672
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 722..786
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 735..796
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 767..777
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 845..906
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 877..887
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 986..996
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 1050..1114
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 1063..1124
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 1095..1105
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
SQ SEQUENCE 1350 AA; 145675 MW; DCB67EB801DC2AA3 CRC64;
MLFIIAISVI ISLQLGATYS NGCSEGSVRL VGPDVNVTRY GRLEICSSGL WHSVCADGSF
CSLTAKVICR QLGLSTTGAQ AYGLALFGEG NGTVGYQDVS CTGNELNITQ CNYTTPSTCS
HEFDGGVLCN PQAICLDVGG FSSCCDTYHC YISYPYNCWC DELCHSMDDC CPGVEFTCPH
PNSVPSNHSE LGGNAVCTSV GDVKFDDGNE TAGRIAVCDT DHYWKTVCST GFTVNEATVV
CKSLGLSVSK VTPLYNNNEY GQGLEDVYSK TVSCYGNESQ LLDCKGYKSC CGHQYDIGVS
CESSCTSGTI RLVGGPTDRE GRVEVCHNGR WGTICDKEWD IYDAYVICRT MGLPWRGAQA
FTGGYTSSVY GSGTTGQVIW IEDIECTGEE NQLNECVSED QYGDKGNCQH SNDVSMICAP
GPCALAGYNE TCCDPSTGAS CQGVNPNTVC HCSLDCEDHN DCCIDADLIC QCHNYDLRLV
GGTVPNEGRV EMCYEGEWGT ICDDYWGNRD AQVVCRQLGY LSTGARAFSY AYFGQGTGSI
YLDNVYCNGQ ESKLIDCPRG YKNIGDHNCV HYEDASVRCH VAPECTSPDI RLANGENSFE
GELQICHNGA WSKACIIDNY LYVSKNALVA CRTIFGSTKV STFYFSYSWW SSGSPGVGSI
RCNGYESNLA NCFDDYNTYK NCPNAVLTCY PQWRYAGQPM LIPGPQYGRL LVSVDDTWGT
VCKDLFDVND ARVVCIELGL PASSPRVYRD GQFGAGRGQI HYNYVQCNGS ETHLNNCTKT
TIGIYCSHYD DVGVGCEESC TNGTVRLIEG GAPNEGRVEI CANEMWGTIC DTEGSWGAEE
ATVICRQLGL PHTAAQPAAY NEFGPGADPF QYTKVQCTGS EESIELCDKY EATLCSTHNQ
DVGVKCIGAC TTGSVSLVDG NNVTNGRLQV CLGGHWGTVC DNRFNELDAM IVCKQLGYPH
EGAEVREGGF YGGGTEYGIA LTSLSCQGNE QSITDCVFGT GSDVNCNHDN DVGVVCQDTC
TNGDIRLADK EGENGGRIEV CYNKKWGTIC HKGWTTEDAR VACYQLGYDP TYVRTFSGNK
FGPGIGPVQF KDINCTGNET DLKYCSVDIG TSDCSHNEDS GLRCDGNKLV NDTRIGYMPN
PLPSPGYITN SSISVLNNTA VEIHWNKPHN GQSVPVQYNI TIGSRTVSVI GSEYSVIINN
LSPGVLYSYQ VVVSNIFGPG LPQTSNHFFT AELAPVGAVT IQSVEWVNDY TVQLVWSPLA
LTEARGFISN YNINISSYVN GTCGIEPVAT DSAPANNNDT NSNINHTIAT RGGVMVPSLI
YCVTITANNS IGTGPNSSPF IINSTSNTIH
//
