ID A0A1X7UGE2_AMPQE Unreviewed; 503 AA.
AC A0A1X7UGE2;
DT 05-JUL-2017, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2017, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=Receptor ligand binding region domain-containing protein {ECO:0000259|Pfam:PF01094};
OS Amphimedon queenslandica (Sponge).
OC Eukaryota; Metazoa; Porifera; Demospongiae; Heteroscleromorpha;
OC Haplosclerida; Niphatidae; Amphimedon.
OX NCBI_TaxID=400682 {ECO:0000313|EnsemblMetazoa:Aqu2.1.26551_001, ECO:0000313|Proteomes:UP000007879};
RN [1] {ECO:0000313|Proteomes:UP000007879}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20686567; DOI=10.1038/nature09201;
RA Srivastava M., Simakov O., Chapman J., Fahey B., Gauthier M.E., Mitros T.,
RA Richards G.S., Conaco C., Dacre M., Hellsten U., Larroux C., Putnam N.H.,
RA Stanke M., Adamska M., Darling A., Degnan S.M., Oakley T.H.,
RA Plachetzki D.C., Zhai Y., Adamski M., Calcino A., Cummins S.F.,
RA Goodstein D.M., Harris C., Jackson D.J., Leys S.P., Shu S., Woodcroft B.J.,
RA Vervoort M., Kosik K.S., Manning G., Degnan B.M., Rokhsar D.S.;
RT "The Amphimedon queenslandica genome and the evolution of animal
RT complexity.";
RL Nature 466:720-726(2010).
RN [2] {ECO:0000313|Proteomes:UP000007879}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Lucas S., Shapiro H., Lindquist E., Tice H., Dalin E., Glavina del Rio T.,
RA Bruce D., Barry K., Pitluck S., Srivastava M., Simakov O., Chapman J.,
RA Mitros T., Hellsten U., Putnam N.H., Fahey B., Gauthier M., Larroux C.,
RA Richards G.S., Stanke M., Adamska M., Darling A., Dacre M., Degnan S.M.,
RA Zhai Y., Adamski M., Calcino A., Cummins S.F., Goodstein D.M., Harris C.,
RA Shu S., Woodcroft B., Leys S.P., Manning G., Degnan B.M., Rokhsar D.S.;
RT "The genome of the haplosclerid demosponge Amphimedon queenslandica and the
RT evolution of animal complexity.";
RL Submitted (MAY-2010) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EnsemblMetazoa:Aqu2.1.26551_001}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (MAY-2017) to UniProtKB.
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DR AlphaFoldDB; A0A1X7UGE2; -.
DR EnsemblMetazoa; Aqu2.1.26551_001; Aqu2.1.26551_001; Aqu2.1.26551.
DR eggNOG; KOG1055; Eukaryota.
DR InParanoid; A0A1X7UGE2; -.
DR Proteomes; UP000007879; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004965; F:G protein-coupled GABA receptor activity; IEA:InterPro.
DR Gene3D; 3.40.50.2300; -; 2.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR002455; GPCR3_GABA-B.
DR InterPro; IPR000337; GPCR_3.
DR InterPro; IPR028082; Peripla_BP_I.
DR PANTHER; PTHR10519; GABA-B RECEPTOR; 1.
DR PANTHER; PTHR10519:SF20; GAMMA-AMINOBUTYRIC ACID TYPE B RECEPTOR SUBUNIT 2; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR PRINTS; PR01176; GABABRECEPTR.
DR PRINTS; PR00248; GPCRMGR.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000007879};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..503
FT /note="Receptor ligand binding region domain-containing
FT protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5012372235"
FT TRANSMEM 358..385
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 397..426
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 45..296
FT /note="Receptor ligand binding region"
FT /evidence="ECO:0000259|Pfam:PF01094"
SQ SEQUENCE 503 AA; 57231 MW; AB6ACD6FE927B72E CRC64;
MCKLLFYFWF IAPFISTIES ATKSTLQFGY ITTITGSFLA SGGRPAVDLA LQIINERDDI
LQNYTLAYTD ILDSGCNHTE ALDNFFELMN RDATYISLLG CGCSTATIPV AEISLYWNIP
QLAYAAAANV LNDRTRFRNF FSTLVSFRYV GESLGQLMRE FGWRQMSIIA QDDHLLFSRV
TDELASVIFK NEGWILDRYD VLSGHNPLLF FDRSEAQKFR IIHINAYPDI AYPVLCEAYY
RGMFGSKYLW ILPSWYNAGW WRSNSPSSSN NDSCTDEIMM QGQIKFNRYD SRNDNVILYQ
QYRLINEILT KVPIGAVTVE LHRNTFVFET GESNSTLWNN GEPPYDGFPV TNIDKNNLVL
VVIYNVAATG GLVFACACFT FNFVFRRRKI VKLTSCNLNN IIILGSALLY TRLLIEASLF
LGLIFIPKMI CLYLDPQGEK VFSQSGATAA PTNSHALTNN SVDQKEPSEK IILNLRKRVK
ELEGQLNLTK LMKEKSHVPT LFY
//
