ID A0A1X7UGT8_AMPQE Unreviewed; 550 AA.
AC A0A1X7UGT8;
DT 05-JUL-2017, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2017, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=Caspase family p20 domain-containing protein {ECO:0000259|PROSITE:PS50208};
GN Name=105313442 {ECO:0000313|EnsemblMetazoa:Aqu2.1.26865_001};
OS Amphimedon queenslandica (Sponge).
OC Eukaryota; Metazoa; Porifera; Demospongiae; Heteroscleromorpha;
OC Haplosclerida; Niphatidae; Amphimedon.
OX NCBI_TaxID=400682 {ECO:0000313|EnsemblMetazoa:Aqu2.1.26865_001, ECO:0000313|Proteomes:UP000007879};
RN [1] {ECO:0000313|Proteomes:UP000007879}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20686567; DOI=10.1038/nature09201;
RA Srivastava M., Simakov O., Chapman J., Fahey B., Gauthier M.E., Mitros T.,
RA Richards G.S., Conaco C., Dacre M., Hellsten U., Larroux C., Putnam N.H.,
RA Stanke M., Adamska M., Darling A., Degnan S.M., Oakley T.H.,
RA Plachetzki D.C., Zhai Y., Adamski M., Calcino A., Cummins S.F.,
RA Goodstein D.M., Harris C., Jackson D.J., Leys S.P., Shu S., Woodcroft B.J.,
RA Vervoort M., Kosik K.S., Manning G., Degnan B.M., Rokhsar D.S.;
RT "The Amphimedon queenslandica genome and the evolution of animal
RT complexity.";
RL Nature 466:720-726(2010).
RN [2] {ECO:0000313|Proteomes:UP000007879}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Lucas S., Shapiro H., Lindquist E., Tice H., Dalin E., Glavina del Rio T.,
RA Bruce D., Barry K., Pitluck S., Srivastava M., Simakov O., Chapman J.,
RA Mitros T., Hellsten U., Putnam N.H., Fahey B., Gauthier M., Larroux C.,
RA Richards G.S., Stanke M., Adamska M., Darling A., Dacre M., Degnan S.M.,
RA Zhai Y., Adamski M., Calcino A., Cummins S.F., Goodstein D.M., Harris C.,
RA Shu S., Woodcroft B., Leys S.P., Manning G., Degnan B.M., Rokhsar D.S.;
RT "The genome of the haplosclerid demosponge Amphimedon queenslandica and the
RT evolution of animal complexity.";
RL Submitted (MAY-2010) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EnsemblMetazoa:Aqu2.1.26865_001}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (MAY-2017) to UniProtKB.
CC -!- SIMILARITY: Belongs to the peptidase C14A family.
CC {ECO:0000256|ARBA:ARBA00010134}.
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DR RefSeq; XP_011405185.1; XM_011406883.2.
DR AlphaFoldDB; A0A1X7UGT8; -.
DR STRING; 400682.A0A1X7UGT8; -.
DR EnsemblMetazoa; Aqu2.1.26865_001; Aqu2.1.26865_001; Aqu2.1.26865.
DR GeneID; 105313442; -.
DR KEGG; aqu:105313442; -.
DR InParanoid; A0A1X7UGT8; -.
DR Proteomes; UP000007879; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0004197; F:cysteine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR CDD; cd00048; DSRM_SF; 1.
DR Gene3D; 3.30.160.20; -; 1.
DR Gene3D; 3.40.50.1460; -; 1.
DR InterPro; IPR029030; Caspase-like_dom_sf.
DR InterPro; IPR011600; Pept_C14_caspase.
DR InterPro; IPR001309; Pept_C14_p20.
DR InterPro; IPR015917; Pept_C14A.
DR PANTHER; PTHR22576:SF41; CASPASE 23-RELATED; 1.
DR PANTHER; PTHR22576; MUCOSA ASSOCIATED LYMPHOID TISSUE LYMPHOMA TRANSLOCATION PROTEIN 1/PARACASPASE; 1.
DR Pfam; PF00656; Peptidase_C14; 1.
DR PRINTS; PR00376; IL1BCENZYME.
DR SMART; SM00115; CASc; 1.
DR SUPFAM; SSF52129; Caspase-like; 1.
DR SUPFAM; SSF54768; dsRNA-binding domain-like; 1.
DR PROSITE; PS50208; CASPASE_P20; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000007879}.
FT DOMAIN 17..149
FT /note="Caspase family p20"
FT /evidence="ECO:0000259|PROSITE:PS50208"
FT REGION 288..320
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 304..320
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 550 AA; 60301 MW; 47522AF9B173943A CRC64;
MARETVLEEL FEAAPEAVGL AMIITNDYKD NPKYSNLEAT ESDGASMAAA FTELGYTIVH
KHNITGLILA SILRRTSNIQ YPKSCKRIAF VFAGHGRNES KSETTLLIMN DGESITIDFI
VETLSPRDPG NAIGNKVRMF FIDACRGDGK DEGRLVPRGG DCIEKQRLSS NAANYLLCFS
TLAGFQSYEV KETGGGSRGL WLPRIARNLT TCDDSIGDIL VKVNEELSTE FQDKEKYPYM
MQPVLTQTLN ESVFLLREKP QAGLSVKHTA KTTSSDKDQR SNLYHRATSL PTKPSAGQAS
RPELAAAFSQ QTHGAQIHTS EQSLPPVFAQ STSLPGGNLC VTPPSRQKCQ VEAREGATSL
PSRIELVQRK APLPDDSGYY KKQLNELMQK KIISDSYTKS WKVVPDPKIQ GKFKATVECV
LLVGDNSTVS GDSKEYYDKK NLAKEAAAED AVRKIEKILP RAASASISSP PPIAIVRSDI
PVLMNKQNLN NHFQGELRDS LPIYDTVPVD SGFQCSITHK RFGIKAITGD VCSSKREAED
SAASKALKHC
//
