ID A0A1X7UHQ2_AMPQE Unreviewed; 1412 AA.
AC A0A1X7UHQ2;
DT 05-JUL-2017, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2017, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=C-terminal of Roc (COR) domain-containing protein {ECO:0000259|Pfam:PF16095};
OS Amphimedon queenslandica (Sponge).
OC Eukaryota; Metazoa; Porifera; Demospongiae; Heteroscleromorpha;
OC Haplosclerida; Niphatidae; Amphimedon.
OX NCBI_TaxID=400682 {ECO:0000313|EnsemblMetazoa:Aqu2.1.27302_001, ECO:0000313|Proteomes:UP000007879};
RN [1] {ECO:0000313|Proteomes:UP000007879}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20686567; DOI=10.1038/nature09201;
RA Srivastava M., Simakov O., Chapman J., Fahey B., Gauthier M.E., Mitros T.,
RA Richards G.S., Conaco C., Dacre M., Hellsten U., Larroux C., Putnam N.H.,
RA Stanke M., Adamska M., Darling A., Degnan S.M., Oakley T.H.,
RA Plachetzki D.C., Zhai Y., Adamski M., Calcino A., Cummins S.F.,
RA Goodstein D.M., Harris C., Jackson D.J., Leys S.P., Shu S., Woodcroft B.J.,
RA Vervoort M., Kosik K.S., Manning G., Degnan B.M., Rokhsar D.S.;
RT "The Amphimedon queenslandica genome and the evolution of animal
RT complexity.";
RL Nature 466:720-726(2010).
RN [2] {ECO:0000313|Proteomes:UP000007879}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Lucas S., Shapiro H., Lindquist E., Tice H., Dalin E., Glavina del Rio T.,
RA Bruce D., Barry K., Pitluck S., Srivastava M., Simakov O., Chapman J.,
RA Mitros T., Hellsten U., Putnam N.H., Fahey B., Gauthier M., Larroux C.,
RA Richards G.S., Stanke M., Adamska M., Darling A., Dacre M., Degnan S.M.,
RA Zhai Y., Adamski M., Calcino A., Cummins S.F., Goodstein D.M., Harris C.,
RA Shu S., Woodcroft B., Leys S.P., Manning G., Degnan B.M., Rokhsar D.S.;
RT "The genome of the haplosclerid demosponge Amphimedon queenslandica and the
RT evolution of animal complexity.";
RL Submitted (MAY-2010) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EnsemblMetazoa:Aqu2.1.27302_001}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (MAY-2017) to UniProtKB.
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DR EnsemblMetazoa; Aqu2.1.27302_001; Aqu2.1.27302_001; Aqu2.1.27302.
DR eggNOG; KOG4177; Eukaryota.
DR InParanoid; A0A1X7UHQ2; -.
DR Proteomes; UP000007879; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd02019; NK; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 3.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR032171; COR.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR24123; ANKYRIN REPEAT-CONTAINING; 1.
DR Pfam; PF00023; Ank; 1.
DR Pfam; PF12796; Ank_2; 2.
DR Pfam; PF16095; COR; 1.
DR SMART; SM00248; ANK; 7.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 3.
DR PROSITE; PS50088; ANK_REPEAT; 3.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|ARBA:ARBA00023043, ECO:0000256|PROSITE-
KW ProRule:PRU00023}; Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000007879};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 38..62
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REPEAT 118..141
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 186..209
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 254..277
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 794..1003
FT /note="C-terminal of Roc (COR)"
FT /evidence="ECO:0000259|Pfam:PF16095"
FT REGION 487..535
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 561..580
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1166..1303
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 487..505
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 518..535
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 564..578
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1174..1201
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1202..1216
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1217..1236
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1237..1263
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1264..1286
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1287..1303
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1412 AA; 159596 MW; D1087BD2113157EC CRC64;
MIDIGQWRAV IGGWNCCKTS VSTKVGGSSE RHLDRAGLLL VLGSSLILGA LFRLFLCSLI
LLSGDVELNP GPTRKYNRTK VEDIGSLIFA CKSKSNDIGL VRQLVNDKHC NVNVKGKDGC
TPLHHACRSG HFEIVKILTN HPQCDIEAED NSKHRPLHKA CVSGNIDIVH HLVIDKHCDV
NAKVKNGYTP LHYACEKGHF EIVKILTDHP QCSSTEAEDK SKYRPLHKAC TSGNVDIVRH
LVFDNDCDVN AKGRNGTPLH YACEKGHFEV VKTLTNHPQC NIEAENSSKY RPLHKACFSG
HIDIVHHLVF EKHCDFNSKG RDDMIRYADR KGYSEIVKIL TSQLDLSSVI EVEGILNRRQ
LRSHEFKTHL DILDYFKRNN TLEVTTDDSK IKRFLLIHQS SGIALVHVVK CILTGPPGAG
KSTLKKRLLN QPLGTGPSLS TGVIDAAVQV NSFRKLSQHN AVVTTEWKEQ ELDEEAVLIT
KKLLPANNTS DESTGTLQPI LSLNEETESP KGIEPPLTTD QEDNTGVAAS SPMSVHNHEV
NDPGFEKESI IVNHQNIAST TPEIISHEEK EIRTDTKVQN NSRSEGLSNY IWNLPNKKVE
GYEKKFEEAK DDNHTMLYMI DTGGQPEFHE MLPALITGPA INLLVFKLTK DLRSRYEITY
RTSTGDSKPY ETSLTHEEVI FRSLASIACL RQNTIGWSFD EKHVPIEDKS EPAAFLIATH
RDQVDENKVS EVNQQLRTKI ENSSHLFDSD LIQFSQSEQI IFPLDATKDK EEVEHLRSFL
HKAMSKNFQE LRIPASWCTL SLKLRKSKKK LFKYDTCFKL AQECGIKDKK EFKKVLWYLH
HTVGIIMHYP DVAGLKDVII TDLQLVFDRI TNLITTCFTF EQLKSAAVER EFRKNGRFSE
LQLDEISSRE KGDPLNTKRL VALLKHLYIV AGPMKAKVDK KTVKYYFMPC ALKPAGVERE
ERDGSVSPAP LLICFECGYT PVGVFCCLVV YLLDQKTDQV LEWKLTGNDQ YRNKITFQVG
QYYDTVTLIS RATYLEVWVQ QKMSPSLNDL CDKVLSSLHK GLVTVTQSLH YTYKSKHMFG
VPCTCTGVPH PAVIEYFSEG AQCTNGNVMQ LDEKHLYWSK MVVQLNSIVQ NTSNKIPLQT
QSESQIPKMS LSNDIIMYTE STQDYSKSSS LLNKRPREAQ EDMSASKRFQ IDSEGSHDST
KSTFEEQQSS GSDIFKNKNR GCKRQREEDS CSESEPTELK KPSTLMQIPE YSKSSTRNKP
QKIETGQFSD EDSKRKQNEH QDGSSTSKRS KISGNNGATE TRTTIEKENS LFCAMLDKEP
QIKDLVRLFQ SSAVHCMIIG IALGVKVNDL LPNPQSTTNN LILVFQRWLD SDKNVTWRNI
LQVCEDYPDE LGKAKSNVKT FLSSDRAREY LK
//
