ID A0A1X7UHV3_AMPQE Unreviewed; 724 AA.
AC A0A1X7UHV3;
DT 05-JUL-2017, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2017, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE SubName: Full=Uncharacterized protein {ECO:0000313|EnsemblMetazoa:Aqu2.1.27048_001};
GN Name=105313407 {ECO:0000313|EnsemblMetazoa:Aqu2.1.27048_001};
OS Amphimedon queenslandica (Sponge).
OC Eukaryota; Metazoa; Porifera; Demospongiae; Heteroscleromorpha;
OC Haplosclerida; Niphatidae; Amphimedon.
OX NCBI_TaxID=400682 {ECO:0000313|EnsemblMetazoa:Aqu2.1.27048_001, ECO:0000313|Proteomes:UP000007879};
RN [1] {ECO:0000313|Proteomes:UP000007879}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20686567; DOI=10.1038/nature09201;
RA Srivastava M., Simakov O., Chapman J., Fahey B., Gauthier M.E., Mitros T.,
RA Richards G.S., Conaco C., Dacre M., Hellsten U., Larroux C., Putnam N.H.,
RA Stanke M., Adamska M., Darling A., Degnan S.M., Oakley T.H.,
RA Plachetzki D.C., Zhai Y., Adamski M., Calcino A., Cummins S.F.,
RA Goodstein D.M., Harris C., Jackson D.J., Leys S.P., Shu S., Woodcroft B.J.,
RA Vervoort M., Kosik K.S., Manning G., Degnan B.M., Rokhsar D.S.;
RT "The Amphimedon queenslandica genome and the evolution of animal
RT complexity.";
RL Nature 466:720-726(2010).
RN [2] {ECO:0000313|Proteomes:UP000007879}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Lucas S., Shapiro H., Lindquist E., Tice H., Dalin E., Glavina del Rio T.,
RA Bruce D., Barry K., Pitluck S., Srivastava M., Simakov O., Chapman J.,
RA Mitros T., Hellsten U., Putnam N.H., Fahey B., Gauthier M., Larroux C.,
RA Richards G.S., Stanke M., Adamska M., Darling A., Dacre M., Degnan S.M.,
RA Zhai Y., Adamski M., Calcino A., Cummins S.F., Goodstein D.M., Harris C.,
RA Shu S., Woodcroft B., Leys S.P., Manning G., Degnan B.M., Rokhsar D.S.;
RT "The genome of the haplosclerid demosponge Amphimedon queenslandica and the
RT evolution of animal complexity.";
RL Submitted (MAY-2010) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EnsemblMetazoa:Aqu2.1.27048_001}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (MAY-2017) to UniProtKB.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the TRIM/RBCC family.
CC {ECO:0000256|ARBA:ARBA00008518}.
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DR RefSeq; XP_019854245.1; XM_019998686.1.
DR AlphaFoldDB; A0A1X7UHV3; -.
DR STRING; 400682.A0A1X7UHV3; -.
DR EnsemblMetazoa; Aqu2.1.27048_001; Aqu2.1.27048_001; Aqu2.1.27048.
DR GeneID; 105313407; -.
DR KEGG; aqu:105313407; -.
DR eggNOG; KOG2177; Eukaryota.
DR InParanoid; A0A1X7UHV3; -.
DR OMA; WMFTSSL; -.
DR OrthoDB; 1752784at2759; -.
DR Proteomes; UP000007879; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd05819; NHL; 1.
DR Gene3D; 4.10.830.40; -; 1.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 2.120.10.30; TolB, C-terminal domain; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR InterPro; IPR017868; Filamin/ABP280_repeat-like.
DR InterPro; IPR001298; Filamin/ABP280_rpt.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR001258; NHL_repeat.
DR InterPro; IPR047153; TRIM45/56/19.
DR InterPro; IPR027370; Znf-RING_euk.
DR InterPro; IPR000315; Znf_B-box.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR017907; Znf_RING_CS.
DR PANTHER; PTHR25462:SF302; B BOX-TYPE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR25462; BONUS, ISOFORM C-RELATED; 1.
DR Pfam; PF00630; Filamin; 1.
DR Pfam; PF01436; NHL; 1.
DR Pfam; PF00643; zf-B_box; 1.
DR Pfam; PF13445; zf-RING_UBOX; 1.
DR SMART; SM00336; BBOX; 2.
DR SMART; SM00557; IG_FLMN; 1.
DR SMART; SM00184; RING; 1.
DR SUPFAM; SSF57845; B-box zinc-binding domain; 1.
DR SUPFAM; SSF81296; E set domains; 1.
DR SUPFAM; SSF101898; NHL repeat; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS50194; FILAMIN_REPEAT; 1.
DR PROSITE; PS51125; NHL; 2.
DR PROSITE; PS50119; ZF_BBOX; 2.
DR PROSITE; PS00518; ZF_RING_1; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000007879};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00024}.
FT DOMAIN 13..57
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT DOMAIN 92..140
FT /note="B box-type"
FT /evidence="ECO:0000259|PROSITE:PS50119"
FT DOMAIN 153..193
FT /note="B box-type"
FT /evidence="ECO:0000259|PROSITE:PS50119"
FT REPEAT 374..460
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 511..553
FT /note="NHL"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00504"
FT REPEAT 558..601
FT /note="NHL"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00504"
FT COILED 222..256
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 724 AA; 80228 MW; 582B6C2D35641D56 CRC64;
MAENTSLAIT MTCEVCSEYY TDPLMLPCLH SFCKKCLIKA KEKQGSTDTS LKCPMCDTSV
NLPDGKIEGL TQNLWFQHKS KEALIKKKIV SKEAVSCDKC DDSSDAAVVY CCDCGQFLCD
LCKKVHKRNK KEASHKLIDL EAKESIELPT VKHEAIYCIQ HSEKLTYYCK DCNNLVCQIC
LNIHHKSHNY NYYVDEGETA RKALKESVAS CDGVIPPVAK AIANGEKMLE QIATRKEEIR
QEIKETFEEL KAALDKRCND LLMETEEIAS AKRSSVKKQL DGFHKLVKQV SHGRHLASSV
RECTDPGEVL SVKKLITNQL EECIEEYKKL PLEIEENEAI VTNLDTSILN KKISEFGTVS
KVHVNIDAYS IDSGLAIPLA TVKKERKFKV ALPAGIDKAA SYLKASFIKS DSNEEEGRVV
IVNDNNTAIV SCTPQSIGGY ELSVTIRGQH IKGSPYQLSV KASRDYTTLT NQRYFDVGNG
TTGVAVHTNG EVFASSRDGF VQVFSEDGTA VRRIGSKGKG NGQFECPWGL LLVGDRLYVS
DDNLHRVQYF SATTGQYIGQ FGSEGIENGQ FSRPFGMSTD GKGNILVADY SNNRVQVFKE
DGTSVQVIQC DGRASDVAVD NEGKIHVTIY NQNYVQVFSP DGKTHLDTYN NPAGNFNGLN
GIAVDDMGYI FVSAYNGDTS YLHALCPDRK QVKLISVSNP FGIALDKNGY IYVTNCNDKR
ITKY
//
