ID A0A1X7ULZ9_AMPQE Unreviewed; 3082 AA.
AC A0A1X7ULZ9;
DT 05-JUL-2017, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2017, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE RecName: Full=Hemicentin-1 {ECO:0008006|Google:ProtNLM};
GN Name=105313132 {ECO:0000313|EnsemblMetazoa:Aqu2.1.28798_001};
OS Amphimedon queenslandica (Sponge).
OC Eukaryota; Metazoa; Porifera; Demospongiae; Heteroscleromorpha;
OC Haplosclerida; Niphatidae; Amphimedon.
OX NCBI_TaxID=400682 {ECO:0000313|EnsemblMetazoa:Aqu2.1.28798_001, ECO:0000313|Proteomes:UP000007879};
RN [1] {ECO:0000313|Proteomes:UP000007879}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20686567; DOI=10.1038/nature09201;
RA Srivastava M., Simakov O., Chapman J., Fahey B., Gauthier M.E., Mitros T.,
RA Richards G.S., Conaco C., Dacre M., Hellsten U., Larroux C., Putnam N.H.,
RA Stanke M., Adamska M., Darling A., Degnan S.M., Oakley T.H.,
RA Plachetzki D.C., Zhai Y., Adamski M., Calcino A., Cummins S.F.,
RA Goodstein D.M., Harris C., Jackson D.J., Leys S.P., Shu S., Woodcroft B.J.,
RA Vervoort M., Kosik K.S., Manning G., Degnan B.M., Rokhsar D.S.;
RT "The Amphimedon queenslandica genome and the evolution of animal
RT complexity.";
RL Nature 466:720-726(2010).
RN [2] {ECO:0000313|Proteomes:UP000007879}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Lucas S., Shapiro H., Lindquist E., Tice H., Dalin E., Glavina del Rio T.,
RA Bruce D., Barry K., Pitluck S., Srivastava M., Simakov O., Chapman J.,
RA Mitros T., Hellsten U., Putnam N.H., Fahey B., Gauthier M., Larroux C.,
RA Richards G.S., Stanke M., Adamska M., Darling A., Dacre M., Degnan S.M.,
RA Zhai Y., Adamski M., Calcino A., Cummins S.F., Goodstein D.M., Harris C.,
RA Shu S., Woodcroft B., Leys S.P., Manning G., Degnan B.M., Rokhsar D.S.;
RT "The genome of the haplosclerid demosponge Amphimedon queenslandica and the
RT evolution of animal complexity.";
RL Submitted (MAY-2010) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EnsemblMetazoa:Aqu2.1.28798_001}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (MAY-2017) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 2 family.
CC Adhesion G-protein coupled receptor (ADGR) subfamily.
CC {ECO:0000256|ARBA:ARBA00007343}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR RefSeq; XP_019853407.1; XM_019997848.1.
DR EnsemblMetazoa; Aqu2.1.28798_001; Aqu2.1.28798_001; Aqu2.1.28798.
DR GeneID; 105313132; -.
DR KEGG; aqu:105313132; -.
DR eggNOG; KOG4193; Eukaryota.
DR eggNOG; KOG4475; Eukaryota.
DR InParanoid; A0A1X7ULZ9; -.
DR OrthoDB; 2917340at2759; -.
DR Proteomes; UP000007879; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:InterPro.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR CDD; cd15040; 7tmB2_Adhesion; 1.
DR CDD; cd00054; EGF_CA; 1.
DR CDD; cd00096; Ig; 5.
DR Gene3D; 2.60.220.50; -; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 19.
DR Gene3D; 2.10.25.10; Laminin; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR046338; GAIN_dom_sf.
DR InterPro; IPR017981; GPCR_2-like_7TM.
DR InterPro; IPR000832; GPCR_2_secretin-like.
DR InterPro; IPR000203; GPS.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR013106; Ig_V-set.
DR PANTHER; PTHR45080; CONTACTIN 5; 1.
DR PANTHER; PTHR45080:SF8; WRAPPER_REGA-1_KLINGON HOMOLOG; 1.
DR Pfam; PF00002; 7tm_2; 1.
DR Pfam; PF00008; EGF; 1.
DR Pfam; PF01825; GPS; 1.
DR Pfam; PF07679; I-set; 2.
DR Pfam; PF13895; Ig_2; 1.
DR Pfam; PF13927; Ig_3; 11.
DR SMART; SM00303; GPS; 1.
DR SMART; SM00409; IG; 19.
DR SMART; SM00408; IGc2; 16.
DR SMART; SM00406; IGv; 5.
DR SUPFAM; SSF57196; EGF/Laminin; 1.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 19.
DR PROSITE; PS00010; ASX_HYDROXYL; 1.
DR PROSITE; PS50026; EGF_3; 1.
DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
DR PROSITE; PS50221; GPS; 1.
DR PROSITE; PS50835; IG_LIKE; 15.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000007879};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..17
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 18..3082
FT /note="Hemicentin-1"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5013005170"
FT TRANSMEM 2580..2602
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2614..2633
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2645..2663
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2683..2704
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2724..2750
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2776..2799
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2805..2829
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 124..219
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 222..319
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 327..427
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 534..630
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 635..731
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 735..835
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 944..1031
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1039..1129
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1140..1307
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1316..1414
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1419..1546
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1553..1647
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1651..1752
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1878..1992
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1997..2037
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2046..2129
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 2578..2830
FT /note="G-protein coupled receptors family 2 profile 2"
FT /evidence="ECO:0000259|PROSITE:PS50261"
FT REGION 2852..2877
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2963..3038
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3050..3082
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2852..2874
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2963..2977
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3002..3038
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3050..3068
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3082 AA; 335635 MW; B905D69F140617CE CRC64;
MAMACLYLVA GVAFLLAGRT IAVAPVVAPL DGSQQVAVSP EPHNLTFVVA PPVFPSNISW
TYHNGLNTEI IDENTNPFLS FSPSRLTLTL SLPLSQNEGT YTLTATNEDG SSSAFITLDI
KSRPAFITLP SSQNKHEREN VTFPCFATGD PTPSIEWIFN DTFVINSSNE KYQIGLFGES
NFGSLTVQDL EFPNTGVYIC RASNQFGSLN ATAVDLGVQV LPSVTSQPSD IAPVAGGVAY
LRCSVRGFPP VNVYWTKNIT NVTELDSVVR YTTNSVYDHS SLTTHSTLTL NGSVLSTDGN
YTCTATNNLK SFESATSMEA EVIVQYPPAT SVSDSTVRVN QSFSTTFNCS SFGIPPPSLF
WYFNGSNLES GGNVVVTRTS FVNESDLYIR SIELAIVNAD RAAREGSYTC VAVNNVNNLI
SSPENVTTQV FVQVPPRLVL PNGPSVLGVV GSSVTLRFQV EDASPDVLPE RTFWSFQGTP
LSSNLSDRFA YSMDRRSLAI NDLTHQDEGL YSVMVVNEAG TDSSEINLHI EAAPVLVSPF
LTDSIVLQGN STELRCSITS EPQPSVQWLF NSNPLNLSIS RLSVGFFNGS EVREYFSVLS
ISEATMGDTG DYTCLVTNVH GTVNNTAHVE VQIPPIITQG PNDTLSIRGF SVSLSCQTFG
SPTPNITWLK GSMAVSSSPS ISITSIRNGF TRESVLTFLN LSFSDAEDYT CLAQNDLVTL
TSGNSTPAQL IVNQPPLLAS STDEFSIFNQ SQTVNISCHF LGLPPPSISW SRSDSADLSD
SVKFTTFISS SEPPEGGVIS SSTLQVTDVG ESDTGNYTCT AANRATGPME PLNITSHSLR
VLVQTSPLVN RVSAQTEIGV LTRNITLVFS VSRDVPAVVP IDIKWFLNGT EILSDDRHMF
SDSRESLSIY NLTLPFDEGE YSVVASNIIG NGTESLFLDV EIAPIITSNS GRVNTIEGNN
ATFHCLGVSE PVHFTSWRFN GTDISPDSIK YSIIGNNTSN STLIVHNVSL TDQGLYACHA
DNVHGVDSAV SVLFVQVPPY ISSPPSSSTV LVNTSAAFRC CSGGIPLPSI QWLKNGTIID
EANRTSFTIQ ESTYENCSVL NIANPVFSDR GEYACVSRNQ LAEELMAISD PVELIVQYPP
QVFRLSQATY TRNESDSFTI ECTSFGVPLP TLYWVPGPLN ITNRIGDGDL FLTNGELASF
LSSISGHTNR LVNLTDQCPM NRGPSVCRGN VESSNDTNVE CDRINGSLCP VSCGIDITSY
NETRDDGRPV SVSRLTLCSL LKSEELSYTC VAVNNVTNDI GTPEAVSANL VVQVEPYVFS
SQTDTQIAFR GHSTTLDFNI SLASPDVPPE GITWSFTHRF LDISEIITGS GDHYEFSESH
RSLTLFNLTT NDTGYYELTA TNPAGTDRHT IELSVQALPE IIRSTRSPVI TVTDSVVPLD
CFADGSPLQN VSWTFTNASG VLLFEIRFVI DNDTARTGYT EYLPLVEGIT RTYIMERFSI
SDNTVPSAME YGRLSIRDIN AFDAGVYTCT LTNEYNLMEP DTYSVQVQVQ LYPSISTHPQ
STQCTSGDSC SLNCTVTGVP APNITWYHDG TLVDDHSIQF TYTYNQTTSV LNIASVNYLT
NSGRYHCVGN NTLYSPGSAE SNEAMLTVLY PSKVLSLPSH TIINETFTAT LTCIVTGNPR
PTVTWSIGSR ALASSNNGKY VITTNNSMGG LLFNVTSVLN ISNVNKSDEA VYTCSSENEV
RNNIGVNRIA ISRLTIQVPP TVVGMNKESV EKGSEIIISF NITRASPPVS LDDIIWSFTS
INDVQSRPMI LNVTCAEMEN ATCVDSQRYQ RYNFTFDHNL TTLTIQDAQV EDYGTFALSV
SNPAGMSSDS HLLKVIVPAL LGNSTGMIFN KTKTQLDEVI NITMSCTADG IPKPGIIWFY
NDAILNFKPR VAFVPQDLNE TIRPDVIHPN GTAVISILTI TNANARDDSG LYACQAENIG
GRSLLDPPNN LIINVPVENY CESSPCQNGG TCNNLERGFY CICGRVGQAV YSGDTCEIRT
ESEIAPRFLS VTSVDIFVAL FKPVTLRCSA EGLPNPSIRW YRDGVFVEGS LGPSPNEYVI
QEIRLEDRGN YHCVASNAVG VVASETVLVN INDVIEYIAN LTVQVSSLRE GVNITSAADT
IVNTINSGIA GEEIGSNSTF FFIVRNGIPL NRTTNITVPI KITIRLQEDT PNDILRRNVE
DRVSKFGHHL EISDNQGVRR FNYCPPDNTD IPSPDGDPAL RLIIEWPEIL FGRVQNVSCP
CDFQLSSTVL LATRNCGGNL ITGAAWERPN IQPCNFSVTT RQLCRLANLS SSELLNGLDN
ITGNIDKIDS AGVTVSATAI NSVVDDVISN DTLVNTTMNV FNNIQGVSRQ ELVIAQRTSD
SSEKMLRSLF NITNTLPANT TILRDRMAIM TGSFLNSSIS SSHNSTSNAT VMLPDGFLRD
NRDNPFVFSV FTSDSLFIPN EDDGSTVGTP VLDFTLPDQD VSNLAEPIQL MFPNFTPPAD
GSRIPVCRFW DTENNEWSSD GCSLVGGNIC SCDHLTSFAI LLDVAAEEPP TAAEAEVFQY
LTYIGLTVSI ICLIVTLITY LGTPKLRNSE ASQLLIHLSF ALLGLYFTFI IAAQGDRLTK
PVCGIIGALV HYFFLAVFFI MAAESVDLFI KLVIVLGPKI QRFILKTAII GWIAPLFVVL
FCFVPDSDHY IHPHYCGPSG FPLYIGILLP FSVIYIFNYT IFFIIMISLI KKSASSKFSE
AKKKNRKAEI KKQCRVAFTV SVLFGLGWGF GVLASSAIGS TPVRIIFNSI FTIFTVFQGF
FIFLLYVVLS PNARNIWKRW ILRKEATKST EASSSVGPST SRTTQKTNAS NNYGRKAGGI
GGGKGTLYRN VYSAAKGKSS SPYITKDLIS SEFASSQPVV EELKERLRFR SIDDEDEDRT
FMNPLDDLGD VMSLVSDTQS LHETTFSFPN PNPPSSQSQE EDDEERDDLG DIEEGPGKCS
TFKNPLRQSL HRTTSRSSRP PDETELLSQS TSTDEPAQTV TLDLNAINGF TLSNGSSSLS
QSQGLSGHDG SLLIRDEQVS EL
//
