ID A0A1X7UV49_AMPQE Unreviewed; 529 AA.
AC A0A1X7UV49;
DT 05-JUL-2017, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2017, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=PX domain-containing protein {ECO:0000259|PROSITE:PS50195};
GN Name=100638772 {ECO:0000313|EnsemblMetazoa:Aqu2.1.31399_001};
OS Amphimedon queenslandica (Sponge).
OC Eukaryota; Metazoa; Porifera; Demospongiae; Heteroscleromorpha;
OC Haplosclerida; Niphatidae; Amphimedon.
OX NCBI_TaxID=400682 {ECO:0000313|EnsemblMetazoa:Aqu2.1.31399_001, ECO:0000313|Proteomes:UP000007879};
RN [1] {ECO:0000313|Proteomes:UP000007879}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20686567; DOI=10.1038/nature09201;
RA Srivastava M., Simakov O., Chapman J., Fahey B., Gauthier M.E., Mitros T.,
RA Richards G.S., Conaco C., Dacre M., Hellsten U., Larroux C., Putnam N.H.,
RA Stanke M., Adamska M., Darling A., Degnan S.M., Oakley T.H.,
RA Plachetzki D.C., Zhai Y., Adamski M., Calcino A., Cummins S.F.,
RA Goodstein D.M., Harris C., Jackson D.J., Leys S.P., Shu S., Woodcroft B.J.,
RA Vervoort M., Kosik K.S., Manning G., Degnan B.M., Rokhsar D.S.;
RT "The Amphimedon queenslandica genome and the evolution of animal
RT complexity.";
RL Nature 466:720-726(2010).
RN [2] {ECO:0000313|Proteomes:UP000007879}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Lucas S., Shapiro H., Lindquist E., Tice H., Dalin E., Glavina del Rio T.,
RA Bruce D., Barry K., Pitluck S., Srivastava M., Simakov O., Chapman J.,
RA Mitros T., Hellsten U., Putnam N.H., Fahey B., Gauthier M., Larroux C.,
RA Richards G.S., Stanke M., Adamska M., Darling A., Dacre M., Degnan S.M.,
RA Zhai Y., Adamski M., Calcino A., Cummins S.F., Goodstein D.M., Harris C.,
RA Shu S., Woodcroft B., Leys S.P., Manning G., Degnan B.M., Rokhsar D.S.;
RT "The genome of the haplosclerid demosponge Amphimedon queenslandica and the
RT evolution of animal complexity.";
RL Submitted (MAY-2010) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EnsemblMetazoa:Aqu2.1.31399_001}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (MAY-2017) to UniProtKB.
CC -!- SIMILARITY: Belongs to the sorting nexin family.
CC {ECO:0000256|ARBA:ARBA00010883}.
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DR RefSeq; XP_003386746.1; XM_003386698.3.
DR AlphaFoldDB; A0A1X7UV49; -.
DR STRING; 400682.A0A1X7UV49; -.
DR EnsemblMetazoa; Aqu2.1.31399_001; Aqu2.1.31399_001; Aqu2.1.31399.
DR GeneID; 100638772; -.
DR KEGG; aqu:100638772; -.
DR eggNOG; KOG2273; Eukaryota.
DR InParanoid; A0A1X7UV49; -.
DR OrthoDB; 1891044at2759; -.
DR Proteomes; UP000007879; Unassembled WGS sequence.
DR GO; GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.
DR CDD; cd07623; BAR_SNX1_2; 1.
DR CDD; cd06859; PX_SNX1_2_like; 1.
DR Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR Gene3D; 3.30.1520.10; Phox-like domain; 1.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR001683; PX_dom.
DR InterPro; IPR036871; PX_dom_sf.
DR InterPro; IPR015404; Vps5_C.
DR PANTHER; PTHR10555:SF170; FI18122P1; 1.
DR PANTHER; PTHR10555; SORTING NEXIN; 1.
DR Pfam; PF00787; PX; 1.
DR Pfam; PF09325; Vps5; 1.
DR SMART; SM00312; PX; 1.
DR SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR SUPFAM; SSF64268; PX domain; 1.
DR PROSITE; PS50195; PX; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000007879}.
FT DOMAIN 146..274
FT /note="PX"
FT /evidence="ECO:0000259|PROSITE:PS50195"
FT REGION 1..145
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 23..48
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 59..75
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 78..92
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 130..145
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 529 AA; 59899 MW; 3A0E644E64D11B71 CRC64;
MADEPPPLDV EASPPPDDND ELSEDNIFGK PSLDEPEPAK KEETKKEEDL FGEEEETEAP
PASTERPHTD SEPPTLEPDD PEPPPPVVEV PPAAEKPVTT SAPSGGDLFD EEGEEEPKQK
PVTQEAEAPA SKEEEEEEEE EDVDQYELTI TVAEPEKVGD GMGAYMTYLV TTKTTLPSFK
EPEVFVRRRF SDFLGLYYRL SEKFMCMGYI VPPAPEKSVT GMTKIKFSKN EENSALFIQR
RRANLERFLN RLAIHPVIRK DEDFKMFLEN PGELPKAKDT SAMSGAGLMR LVKNVGDTFS
KIAGKKGDVD SWFDDRQSEY ETLDTHLKKL HSCIESMISA RKELCGCTAG LVKNLAMLAN
VEENNSVSRA LTRLSEVEEK VESLHSEQSN VDLYVFGETI RDYVALLGSL RETFNQRVKN
YGVWTNAQKT LQSKRDSEAK MQTTGKTDKL PIVQAEIKDW EQKEKDAEKA FNKCSKVLKR
EVERFETVRT KEFKAKFLEH LEALMHMQEE LIRLWEGYLP DVQAIEAES
//
