ID A0A1X7UVC6_AMPQE Unreviewed; 1146 AA.
AC A0A1X7UVC6;
DT 05-JUL-2017, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2017, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE RecName: Full=RNA helicase {ECO:0008006|Google:ProtNLM};
GN Name=100638901 {ECO:0000313|EnsemblMetazoa:Aqu2.1.31337_001};
OS Amphimedon queenslandica (Sponge).
OC Eukaryota; Metazoa; Porifera; Demospongiae; Heteroscleromorpha;
OC Haplosclerida; Niphatidae; Amphimedon.
OX NCBI_TaxID=400682 {ECO:0000313|EnsemblMetazoa:Aqu2.1.31337_001, ECO:0000313|Proteomes:UP000007879};
RN [1] {ECO:0000313|Proteomes:UP000007879}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20686567; DOI=10.1038/nature09201;
RA Srivastava M., Simakov O., Chapman J., Fahey B., Gauthier M.E., Mitros T.,
RA Richards G.S., Conaco C., Dacre M., Hellsten U., Larroux C., Putnam N.H.,
RA Stanke M., Adamska M., Darling A., Degnan S.M., Oakley T.H.,
RA Plachetzki D.C., Zhai Y., Adamski M., Calcino A., Cummins S.F.,
RA Goodstein D.M., Harris C., Jackson D.J., Leys S.P., Shu S., Woodcroft B.J.,
RA Vervoort M., Kosik K.S., Manning G., Degnan B.M., Rokhsar D.S.;
RT "The Amphimedon queenslandica genome and the evolution of animal
RT complexity.";
RL Nature 466:720-726(2010).
RN [2] {ECO:0000313|Proteomes:UP000007879}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Lucas S., Shapiro H., Lindquist E., Tice H., Dalin E., Glavina del Rio T.,
RA Bruce D., Barry K., Pitluck S., Srivastava M., Simakov O., Chapman J.,
RA Mitros T., Hellsten U., Putnam N.H., Fahey B., Gauthier M., Larroux C.,
RA Richards G.S., Stanke M., Adamska M., Darling A., Dacre M., Degnan S.M.,
RA Zhai Y., Adamski M., Calcino A., Cummins S.F., Goodstein D.M., Harris C.,
RA Shu S., Woodcroft B., Leys S.P., Manning G., Degnan B.M., Rokhsar D.S.;
RT "The genome of the haplosclerid demosponge Amphimedon queenslandica and the
RT evolution of animal complexity.";
RL Submitted (MAY-2010) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EnsemblMetazoa:Aqu2.1.31337_001}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (MAY-2017) to UniProtKB.
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DR RefSeq; XP_019852260.1; XM_019996701.1.
DR AlphaFoldDB; A0A1X7UVC6; -.
DR STRING; 400682.A0A1X7UVC6; -.
DR EnsemblMetazoa; Aqu2.1.31337_001; Aqu2.1.31337_001; Aqu2.1.31337.
DR GeneID; 100638901; -.
DR KEGG; aqu:100638901; -.
DR eggNOG; KOG0922; Eukaryota.
DR InParanoid; A0A1X7UVC6; -.
DR OrthoDB; 1095660at2759; -.
DR Proteomes; UP000007879; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR CDD; cd18791; SF2_C_RHA; 1.
DR Gene3D; 1.20.120.1080; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR011709; DEAD-box_helicase_OB_fold.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR007502; Helicase-assoc_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR18934; ATP-DEPENDENT RNA HELICASE; 1.
DR PANTHER; PTHR18934:SF148; ATP-DEPENDENT RNA HELICASE DHX34-RELATED; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF21010; HA2_C; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF07717; OB_NTP_bind; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00847; HA2; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000007879}.
FT DOMAIN 169..329
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 369..537
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 997..1036
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 997..1012
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1022..1036
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1146 AA; 131616 MW; 91711C4E2D591970 CRC64;
MGGAKLYTCI VMDWSKQEKD LDRIFFKNFS LIQRGSQEHK DFWKFFYRYQ KFNASKEKTK
AEKNVEWSAS SEGESSKDPF SFPPVYDRSH RICFNVETDN LEYQLRVLQQ RREDERKKSS
PLTLKHLLEF RSVIRHFLNF QQKTKFQRIQ KIIRDQSELP IYQFKDQILS AVRDNQVVLI
AGDTGCGKST QVPQYLLRGS YEKIACTQPR RIACLSLAKR VSYETLNEYR TEIAYQVRFE
RSRTPATKVL FLTEGLLLRQ LSTDRDLSRY DVIIIDEVHE RHINSDFLLG VLRILIDQRS
DLKLILMSAT INISLFSDYF QGAPVIKVPG RLYPIDLQYM PISNASVLQP TAQKSSKLDP
QPYLRILQLI DNKYPRSERG DVLVFLSGMN EIASLLHEVK SYGEATGRWI GLPLHSALSI
EEQDKVFDVA PDGTRKCIIS TNIAETSITI DGIRFVIDSG KVKEMGYDSH TKMNRLQEFW
ISQASSEQRK GRAGRTGPGV CFRLYSESDY SSFPEYATPE IQRVPLESLV LQTIALDLGN
IRKFPFIESP SLSSIETSVA FLKEQDALTN DERLTPVGKM LAQLPVDVVI GKMLIMGSLF
HVIEPVLIIA AGLSVQSPFT QTAFNQDESS AQSTRQSLES DHGDPYTLLN AFDEWINVKR
DGVKASSQWC KRRGIEEQRL YEMVKLRQQF RDVLLDHELL EREFHEASGE EEERERKSRW
FQLSEVQQEE LRSMRKRHRT ENKQRKVLKM DHEVDEEEEV SIAAGLKHLE FKLLHDLSQL
QDGSSERRSY SLRDINLLKI VICSGLYPQV AIGDDCNTFK KGSEQIFHTK SKSFLVLHPT
SVFSSNPDLL FQQQEGGKKV HYLLAYEKLL ETNRPYMVNA LKVPALQTLL LFTQSIDTNE
SCSRLVVDEW LEIVFTGEDT GQEVMSIVQT LRGTWSRILE MKLAKKSKRD DEDDDQGRES
DEIQSLERLL GSRLAEFLDS DYNYTLSQIS SSIRPHLYKG PSSTSTTSGG EGGGTKGLPG
KLTVGSSKSS PSPHPTKGGF MITHYFTYDC LVDPSQAEAS SSLSQHLRNV WVCPSCHQSL
VVNMAEQLSH RGECEIEQQA KRKEEKRKEE ERAVINTREY HCKECDRVFQ FTSIEILRHK
RQHKQN
//
